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Q8D340

- ARND_WIGBR

UniProt

Q8D340 - ARND_WIGBR

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Protein

Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD

Gene

arnD

Organism
Wigglesworthia glossinidia brevipalpis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

Catalytic activityi

4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Source: UniProtKB-HAMAP

GO - Biological processi

  1. 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process Source: UniProtKB-UniPathway
  2. lipid A biosynthetic process Source: UniProtKB-HAMAP
  3. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
  4. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00036; UER00496.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDUniRule annotation (EC:3.5.1.n3UniRule annotation)
Gene namesi
Name:arnDUniRule annotation
Ordered Locus Names:WIGBR1610
OrganismiWigglesworthia glossinidia brevipalpis
Taxonomic identifieri36870 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia
ProteomesiUP000000562: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDPRO_0000383549Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi36870.WGLp161.

Structurei

3D structure databases

ProteinModelPortaliQ8D340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 248248NodB homologyUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.UniRule annotation
Contains 1 NodB homology domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0726.
OMAiLHAWDHF.
OrthoDBiEOG6423D0.

Family and domain databases

Gene3Di3.20.20.370. 2 hits.
HAMAPiMF_01870. ArnD.
InterProiIPR023557. ArnD.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. Polysac_deacetylase.
[Graphical view]
PfamiPF01522. Polysacc_deac_1. 1 hit.
[Graphical view]
SUPFAMiSSF88713. SSF88713. 2 hits.
PROSITEiPS51677. NODB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8D340-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTKLGVPNL WEILNKKKIK ATFFFTVGPD NMGRHFWRLI KPKFLFKMFR
60 70 80 90 100
INPFKIYGLN ILRSGFIGKG KNIGKICKNE IKSASKDHEI GLHAWDHFSW
110 120 130 140 150
QTWINMFSKK KIIKHINLGK NALQHIIKYP VTCFASPGWR TNEYVLRTLK
160 170 180 190 200
NNFNFSYNSD CRGSNLFFPY LGDGKIGSLQ IPVTLPTFDE VINIKTTIKK
210 220 230 240 250
YNSFIIKLIK TQLNFSVYTI HAEIEGMKYK KEFEEFLNIA INEGINFCRL
260 270 280
KDLIPKEIEN IPIYKINHKT IPGRDGWIAY QQKIIK
Length:286
Mass (Da):33,430
Last modified:March 1, 2003 - v1
Checksum:iEF5F1A80805DC731
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000021 Genomic DNA. Translation: BAC24307.1.
RefSeqiNP_871164.1. NC_004344.2.

Genome annotation databases

EnsemblBacteriaiBAC24307; BAC24307; BAC24307.
GeneIDi1256956.
KEGGiwbr:WGLp161.
PATRICi24024475. VBIWigGlo15804_0180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000021 Genomic DNA. Translation: BAC24307.1 .
RefSeqi NP_871164.1. NC_004344.2.

3D structure databases

ProteinModelPortali Q8D340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36870.WGLp161.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC24307 ; BAC24307 ; BAC24307 .
GeneIDi 1256956.
KEGGi wbr:WGLp161.
PATRICi 24024475. VBIWigGlo15804_0180.

Phylogenomic databases

eggNOGi COG0726.
OMAi LHAWDHF.
OrthoDBi EOG6423D0.

Enzyme and pathway databases

UniPathwayi UPA00030 .
UPA00036 ; UER00496 .

Family and domain databases

Gene3Di 3.20.20.370. 2 hits.
HAMAPi MF_01870. ArnD.
InterProi IPR023557. ArnD.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. Polysac_deacetylase.
[Graphical view ]
Pfami PF01522. Polysacc_deac_1. 1 hit.
[Graphical view ]
SUPFAMi SSF88713. SSF88713. 2 hits.
PROSITEi PS51677. NODB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
    Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
    Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiARND_WIGBR
AccessioniPrimary (citable) accession number: Q8D340
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3