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Q8D340 (ARND_WIGBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD

EC=3.5.1.n3
Gene names
Name:arnD
Ordered Locus Names:WIGBR1610
OrganismWigglesworthia glossinidia brevipalpis [Complete proteome] [HAMAP]
Taxonomic identifier36870 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides By similarity. HAMAP-Rule MF_01870

Catalytic activity

4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate. HAMAP-Rule MF_01870

Pathway

Glycolipid biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate: step 2/2. HAMAP-Rule MF_01870

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP-Rule MF_01870

Sequence similarities

Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.

Contains 1 NodB homology domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 286286Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD HAMAP-Rule MF_01870
PRO_0000383549

Regions

Domain1 – 248248NodB homology

Sequences

Sequence LengthMass (Da)Tools
Q8D340 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: EF5F1A80805DC731

FASTA28633,430
        10         20         30         40         50         60 
MGTKLGVPNL WEILNKKKIK ATFFFTVGPD NMGRHFWRLI KPKFLFKMFR INPFKIYGLN 

        70         80         90        100        110        120 
ILRSGFIGKG KNIGKICKNE IKSASKDHEI GLHAWDHFSW QTWINMFSKK KIIKHINLGK 

       130        140        150        160        170        180 
NALQHIIKYP VTCFASPGWR TNEYVLRTLK NNFNFSYNSD CRGSNLFFPY LGDGKIGSLQ 

       190        200        210        220        230        240 
IPVTLPTFDE VINIKTTIKK YNSFIIKLIK TQLNFSVYTI HAEIEGMKYK KEFEEFLNIA 

       250        260        270        280 
INEGINFCRL KDLIPKEIEN IPIYKINHKT IPGRDGWIAY QQKIIK 

« Hide

References

[1]"Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000021 Genomic DNA. Translation: BAC24307.1.
RefSeqNP_871164.1. NC_004344.2.

3D structure databases

ProteinModelPortalQ8D340.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING36870.WGLp161.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC24307; BAC24307; BAC24307.
GeneID1256956.
KEGGwbr:WGLp161.
PATRIC24024475. VBIWigGlo15804_0180.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0726.
OMALHAWDHF.
OrthoDBEOG6423D0.

Enzyme and pathway databases

UniPathwayUPA00030.
UPA00036; UER00496.

Family and domain databases

Gene3D3.20.20.370. 2 hits.
HAMAPMF_01870. ArnD.
InterProIPR023557. ArnD.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. Polysac_deacetylase.
[Graphical view]
PfamPF01522. Polysacc_deac_1. 1 hit.
[Graphical view]
SUPFAMSSF88713. SSF88713. 2 hits.
PROSITEPS51677. NODB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARND_WIGBR
AccessionPrimary (citable) accession number: Q8D340
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways