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Q8D333

- SYL_WIGBR

UniProt

Q8D333 - SYL_WIGBR

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Protein
Leucine--tRNA ligase
Gene
leuS, WIGBR1680
Organism
Wigglesworthia glossinidia brevipalpis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:WIGBR1680
OrganismiWigglesworthia glossinidia brevipalpis
Taxonomic identifieri36870 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia
ProteomesiUP000000562: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 864864Leucine--tRNA ligaseUniRule annotation
PRO_0000152117Add
BLAST

Proteomic databases

PRIDEiQ8D333.

Interactioni

Protein-protein interaction databases

STRINGi36870.WGLp168.

Structurei

3D structure databases

ProteinModelPortaliQ8D333.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi619 – 6235"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8D333-1 [UniParc]FASTAAdd to Basket

« Hide

MKKEYSCKEI ERFVQKHWEI NDTFKVLEDS KKDKYYCVSM MPYPSGKLHM    50
GHVRNYVLGD VIARYQRMLG KNVLHPIGWD AFGLPAETAA INNKISPEKW 100
TISSIEYMKN QLKLLGCSYD WSREIITCDP KYYKWEQLLF TKLYNKNKAY 150
KKKSIVNWCP KDKTVLANEQ VIDNLCWRCS SNIEMKKIFQ WFIKITDYAD 200
ELLNDLNDLK LWPKKVKVMQ RNWIGKSKGI DVLFHIKDTN EKILIYVSKL 250
EIFMGITFIV ISKEHKLIKF IENKLPSIAK LIKNYNNEKT LELNLRKKTK 300
DGIFTSLFAI HPISKKILPI WISNFFFTNN DIYQSIAAIP AYNKNELDFA 350
KKYNLPIRYV IKDYFEKIID FKKYNNLKEG ILFNSNIFNG LNLKNGYDRI 400
SKFLISNKIG KRSTHYKLRD WCISRQRYWG APIPVLITKE NKILVVSENE 450
LPVILPKAKN NNIIHSLNSY KDWIYVLNDN KLVKREVDTF DTFMESSWYL 500
HRYTCTKYTK DILDPNATNY WFPVDQYIGG IEHATMHLLY LRFYHKILRD 550
MNFVKCDEPV NRLLCQGMVL SDTFYYFSKS GNKIWTSPKN KNFERNKDNK 600
IINAIDSLGN KLTHIGMSKM SKSKNNGVDP QGIINKYGSD TLRLFIMFAA 650
PPELSLEWSD KGIIGANRFI KKLWKITYNY LNLKKNNNYV FYKKLKEQDN 700
ILLEKSFYVI NKVTKDIDKN QTFNTAIAEI MKLTNHLNSY INKNEYNNIS 750
IIKKVLMIII RLLYPFIPHV CFVLWNEINK NNDIDKTKWP KIKMPFIKNK 800
KKNIVVQING KLKTVISFDI SCNEFLIKKC VIENNKIKNL LNKKKIKNII 850
YVKNKIINIV LDDK 864
Length:864
Mass (Da):102,169
Last modified:March 1, 2003 - v1
Checksum:i62C8A9BD84031F3F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000021 Genomic DNA. Translation: BAC24314.1.
RefSeqiNP_871171.1. NC_004344.2.

Genome annotation databases

EnsemblBacteriaiBAC24314; BAC24314; BAC24314.
GeneIDi1256963.
KEGGiwbr:WGLp168.
PATRICi24024491. VBIWigGlo15804_0188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000021 Genomic DNA. Translation: BAC24314.1 .
RefSeqi NP_871171.1. NC_004344.2.

3D structure databases

ProteinModelPortali Q8D333.
ModBasei Search...

Protein-protein interaction databases

STRINGi 36870.WGLp168.

Proteomic databases

PRIDEi Q8D333.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC24314 ; BAC24314 ; BAC24314 .
GeneIDi 1256963.
KEGGi wbr:WGLp168.
PATRICi 24024491. VBIWigGlo15804_0188.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
    Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
    Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSYL_WIGBR
AccessioniPrimary (citable) accession number: Q8D333
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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