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Q8D333

- SYL_WIGBR

UniProt

Q8D333 - SYL_WIGBR

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Wigglesworthia glossinidia brevipalpis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei622 – 6221ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:WIGBR1680
    OrganismiWigglesworthia glossinidia brevipalpis
    Taxonomic identifieri36870 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia
    ProteomesiUP000000562: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 864864Leucine--tRNA ligasePRO_0000152117Add
    BLAST

    Proteomic databases

    PRIDEiQ8D333.

    Interactioni

    Protein-protein interaction databases

    STRINGi36870.WGLp168.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8D333.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi619 – 6235"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8D333-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKEYSCKEI ERFVQKHWEI NDTFKVLEDS KKDKYYCVSM MPYPSGKLHM    50
    GHVRNYVLGD VIARYQRMLG KNVLHPIGWD AFGLPAETAA INNKISPEKW 100
    TISSIEYMKN QLKLLGCSYD WSREIITCDP KYYKWEQLLF TKLYNKNKAY 150
    KKKSIVNWCP KDKTVLANEQ VIDNLCWRCS SNIEMKKIFQ WFIKITDYAD 200
    ELLNDLNDLK LWPKKVKVMQ RNWIGKSKGI DVLFHIKDTN EKILIYVSKL 250
    EIFMGITFIV ISKEHKLIKF IENKLPSIAK LIKNYNNEKT LELNLRKKTK 300
    DGIFTSLFAI HPISKKILPI WISNFFFTNN DIYQSIAAIP AYNKNELDFA 350
    KKYNLPIRYV IKDYFEKIID FKKYNNLKEG ILFNSNIFNG LNLKNGYDRI 400
    SKFLISNKIG KRSTHYKLRD WCISRQRYWG APIPVLITKE NKILVVSENE 450
    LPVILPKAKN NNIIHSLNSY KDWIYVLNDN KLVKREVDTF DTFMESSWYL 500
    HRYTCTKYTK DILDPNATNY WFPVDQYIGG IEHATMHLLY LRFYHKILRD 550
    MNFVKCDEPV NRLLCQGMVL SDTFYYFSKS GNKIWTSPKN KNFERNKDNK 600
    IINAIDSLGN KLTHIGMSKM SKSKNNGVDP QGIINKYGSD TLRLFIMFAA 650
    PPELSLEWSD KGIIGANRFI KKLWKITYNY LNLKKNNNYV FYKKLKEQDN 700
    ILLEKSFYVI NKVTKDIDKN QTFNTAIAEI MKLTNHLNSY INKNEYNNIS 750
    IIKKVLMIII RLLYPFIPHV CFVLWNEINK NNDIDKTKWP KIKMPFIKNK 800
    KKNIVVQING KLKTVISFDI SCNEFLIKKC VIENNKIKNL LNKKKIKNII 850
    YVKNKIINIV LDDK 864
    Length:864
    Mass (Da):102,169
    Last modified:March 1, 2003 - v1
    Checksum:i62C8A9BD84031F3F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000021 Genomic DNA. Translation: BAC24314.1.
    RefSeqiNP_871171.1. NC_004344.2.

    Genome annotation databases

    EnsemblBacteriaiBAC24314; BAC24314; BAC24314.
    GeneIDi1256963.
    KEGGiwbr:WGLp168.
    PATRICi24024491. VBIWigGlo15804_0188.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000021 Genomic DNA. Translation: BAC24314.1 .
    RefSeqi NP_871171.1. NC_004344.2.

    3D structure databases

    ProteinModelPortali Q8D333.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36870.WGLp168.

    Proteomic databases

    PRIDEi Q8D333.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC24314 ; BAC24314 ; BAC24314 .
    GeneIDi 1256963.
    KEGGi wbr:WGLp168.
    PATRICi 24024491. VBIWigGlo15804_0188.

    Phylogenomic databases

    eggNOGi COG0495.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
      Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
      Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiSYL_WIGBR
    AccessioniPrimary (citable) accession number: Q8D333
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 23, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3