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Q8D2W5

- RIBB_WIGBR

UniProt

Q8D2W5 - RIBB_WIGBR

Protein

3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene

ribB

Organism
Wigglesworthia glossinidia brevipalpis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.UniRule annotation

    Catalytic activityi

    D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate.UniRule annotation

    Cofactori

    Binds 2 divalent metal cations per subunit. Magnesium or manganese.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi38 – 381Magnesium or manganese 1UniRule annotation
    Metal bindingi38 – 381Magnesium or manganese 2UniRule annotation
    Binding sitei42 – 421SubstrateUniRule annotation
    Sitei136 – 1361Essential for catalytic activityUniRule annotation
    Metal bindingi153 – 1531Magnesium or manganese 2UniRule annotation
    Binding sitei174 – 1741SubstrateUniRule annotation
    Sitei174 – 1741Essential for catalytic activityUniRule annotation

    GO - Molecular functioni

    1. 3,4-dihydroxy-2-butanone-4-phosphate synthase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. riboflavin biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Riboflavin biosynthesis

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00275; UER00399.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3,4-dihydroxy-2-butanone 4-phosphate synthaseUniRule annotation (EC:4.1.99.12UniRule annotation)
    Short name:
    DHBP synthaseUniRule annotation
    Gene namesi
    Name:ribBUniRule annotation
    Ordered Locus Names:WIGBR2370
    OrganismiWigglesworthia glossinidia brevipalpis
    Taxonomic identifieri36870 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia
    ProteomesiUP000000562: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2132133,4-dihydroxy-2-butanone 4-phosphate synthasePRO_0000151819Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi36870.WGLp237.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8D2W5.
    SMRiQ8D2W5. Positions 1-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni37 – 382Substrate bindingUniRule annotation
    Regioni150 – 1545Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the DHBP synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0108.
    KOiK02858.
    OMAiQMAKLIR.
    OrthoDBiEOG679TK8.

    Family and domain databases

    Gene3Di3.90.870.10. 1 hit.
    HAMAPiMF_00180. RibB.
    InterProiIPR017945. DHBP_synth_RibB-like_a/b_dom.
    IPR000422. DHBP_synthase_RibB.
    [Graphical view]
    PfamiPF00926. DHBP_synthase. 1 hit.
    [Graphical view]
    SUPFAMiSSF55821. SSF55821. 1 hit.
    TIGRFAMsiTIGR00506. ribB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8D2W5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKKLLSEFG DPVQRVKNAL QSLKRGNGIL VLDDENRENE GDMIFAAENM    50
    TVNQMALAIR FGSGIVCICL TKEKCKILNL PMMVKKNNSK YKTAFTVSIE 100
    SAYGITTGVS AYDRIITIKT AIKDNAKPDD LNRPGHVFPL QAHPGGILSR 150
    AGHTEAAVDL TKLAGLKPAG VICEVMNDDG SMARMPEIIN FSKKYNMPVL 200
    IIKDIIEYYN FIN 213
    Length:213
    Mass (Da):23,510
    Last modified:March 1, 2003 - v1
    Checksum:i5FA5F3B5E3D6C23E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000021 Genomic DNA. Translation: BAC24383.1.
    RefSeqiNP_871240.1. NC_004344.2.

    Genome annotation databases

    EnsemblBacteriaiBAC24383; BAC24383; BAC24383.
    GeneIDi1257036.
    KEGGiwbr:WGLp237.
    PATRICi24024639. VBIWigGlo15804_0258.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000021 Genomic DNA. Translation: BAC24383.1 .
    RefSeqi NP_871240.1. NC_004344.2.

    3D structure databases

    ProteinModelPortali Q8D2W5.
    SMRi Q8D2W5. Positions 1-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36870.WGLp237.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC24383 ; BAC24383 ; BAC24383 .
    GeneIDi 1257036.
    KEGGi wbr:WGLp237.
    PATRICi 24024639. VBIWigGlo15804_0258.

    Phylogenomic databases

    eggNOGi COG0108.
    KOi K02858.
    OMAi QMAKLIR.
    OrthoDBi EOG679TK8.

    Enzyme and pathway databases

    UniPathwayi UPA00275 ; UER00399 .

    Family and domain databases

    Gene3Di 3.90.870.10. 1 hit.
    HAMAPi MF_00180. RibB.
    InterProi IPR017945. DHBP_synth_RibB-like_a/b_dom.
    IPR000422. DHBP_synthase_RibB.
    [Graphical view ]
    Pfami PF00926. DHBP_synthase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55821. SSF55821. 1 hit.
    TIGRFAMsi TIGR00506. ribB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
      Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
      Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiRIBB_WIGBR
    AccessioniPrimary (citable) accession number: Q8D2W5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3