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Protein

5'/3'-nucleotidase SurE

Gene

surE

Organism
Wigglesworthia glossinidia brevipalpis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.UniRule annotation

Catalytic activityi

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
A 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.UniRule annotation

Cofactori

a divalent metal cationUniRule annotationNote: Binds 1 divalent metal cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8Divalent metal cationUniRule annotation1
Metal bindingi9Divalent metal cationUniRule annotation1
Metal bindingi39Divalent metal cationUniRule annotation1
Metal bindingi92Divalent metal cationUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
5'/3'-nucleotidase SurEUniRule annotation (EC:3.1.3.5UniRule annotation, EC:3.1.3.6UniRule annotation)
Alternative name(s):
ExopolyphosphataseUniRule annotation (EC:3.6.1.11UniRule annotation)
Nucleoside monophosphate phosphohydrolaseUniRule annotation
Gene namesi
Name:surEUniRule annotation
Ordered Locus Names:WIGBR3070
OrganismiWigglesworthia glossinidia brevipalpis
Taxonomic identifieri36870 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeWigglesworthia
Proteomesi
  • UP000000562 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001118531 – 2505'/3'-nucleotidase SurEAdd BLAST250

Proteomic databases

PRIDEiQ8D2P7

Interactioni

Protein-protein interaction databases

STRINGi36870.WGLp307

Structurei

3D structure databases

ProteinModelPortaliQ8D2P7
SMRiQ8D2P7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SurE nucleotidase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CV2 Bacteria
COG0496 LUCA
KOiK03787
OMAiDCVHIAL
OrthoDBiPOG091H01CP

Family and domain databases

Gene3Di3.40.1210.10, 1 hit
HAMAPiMF_00060 SurE, 1 hit
InterProiView protein in InterPro
IPR030048 SurE
IPR002828 SurE-like_Pase/nucleotidase
IPR036523 SurE-like_sf
PfamiView protein in Pfam
PF01975 SurE, 1 hit
TIGRFAMsiTIGR00087 surE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8D2P7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNILLSNDDG IYSPGIQKLS KKLKKFLNVQ VIAPSCDKSG SSSSLTINNP
60 70 80 90 100
LKVHKFSNGD ITVYSGTPID CVYLGINFFM KPKPDFVVSG INLGANLGDD
110 120 130 140 150
VFYSGTVGAA MEGRYLKYSS LAISLDGNKH LDVAVEIVYK FLKFLLNNPF
160 170 180 190 200
RKKYILNINI PDSPLKYIKG FKITKCGRKN FKNTVIKSKD SENKNIFWIG
210 220 230 240 250
PKTNCYNESI GTDFHAIKNN YISVTPLLSN LTNNKEINSI SNWFENFYKS
Length:250
Mass (Da):27,998
Last modified:March 1, 2003 - v1
Checksum:iD503F7A056024EA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000021 Genomic DNA Translation: BAC24453.1
RefSeqiWP_011070111.1, NC_004344.2

Genome annotation databases

EnsemblBacteriaiBAC24453; BAC24453; BAC24453
KEGGiwbr:surE

Similar proteinsi

Entry informationi

Entry nameiSURE_WIGBR
AccessioniPrimary (citable) accession number: Q8D2P7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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