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Q8D2N7 (GCH1_WIGBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:WIGBR3170
OrganismWigglesworthia glossinidia brevipalpis [Complete proteome] [HAMAP]
Taxonomic identifier36870 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 216216GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_0000119464

Sites

Metal binding1091Zinc By similarity
Metal binding1121Zinc By similarity
Metal binding1801Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8D2N7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: A58D37B63DFD732F

FASTA21624,698
        10         20         30         40         50         60 
MEVLTKEALL VKNALLNKGI ETPFKKIYEK NKPDIHKISK YIKKIMDLLN LDLNNDSLSK 

        70         80         90        100        110        120 
TPNRIAYMYI EEIFSGLNYN NFPKITLIKN TSKINDLITV NNIVLNSTCE HHFLIFEGKA 

       130        140        150        160        170        180 
IVSYIPDKIL IGLSKINRIV DFFSKRPQIQ ERLTNQILVA IQILLDTKNV AVAIKAKHLC 

       190        200        210 
VKARGIKDSH SKTLTLSLGG VFKSKQNIKK EFLKDF 

« Hide

References

[1]"Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000021 Genomic DNA. Translation: BAC24463.1.
RefSeqNP_871320.1. NC_004344.2.

3D structure databases

ProteinModelPortalQ8D2N7.
SMRQ8D2N7. Positions 3-214.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING36870.WGLp317.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC24463; BAC24463; BAC24463.
GeneID1257123.
KEGGwbr:WGLp317.
PATRIC24024832. VBIWigGlo15804_0347.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
KOK01495.
OMAVQFFSSR.
OrthoDBEOG6XHC8G.

Enzyme and pathway databases

UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_WIGBR
AccessionPrimary (citable) accession number: Q8D2N7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways