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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Wigglesworthia glossinidia brevipalpis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei11SubstrateUniRule annotation1
Binding sitei33SubstrateUniRule annotation1
Active sitei62Proton donorUniRule annotation1
Binding sitei119SubstrateUniRule annotation1
Binding sitei180SubstrateUniRule annotation1
Binding sitei189SubstrateUniRule annotation1
Binding sitei209Substrate; via amide nitrogenUniRule annotation1
Binding sitei210SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:WIGBR3630
OrganismiWigglesworthia glossinidia brevipalpis
Taxonomic identifieri36870 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeWigglesworthia
Proteomesi
  • UP000000562 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001346001 – 232Orotidine 5'-phosphate decarboxylaseAdd BLAST232

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi36870.WGLp363.

Structurei

3D structure databases

ProteinModelPortaliQ8D2J1.
SMRiQ8D2J1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni60 – 69Substrate bindingUniRule annotation10

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106EG9. Bacteria.
COG0284. LUCA.
KOiK01591.
OMAiNFKIFLD.
OrthoDBiPOG091H0256.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
PANTHERiPTHR32119:SF4. PTHR32119:SF4. 1 hit.
PfamiView protein in Pfam
PF00215. OMPdecase. 1 hit.
SMARTiView protein in SMART
SM00934. OMPdecase. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiView protein in PROSITE
PS00156. OMPDECASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8D2J1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSPIIVAL DYSNPKKAIS FSKKISPDQC QLKIGHELFI NSGFFLINFL
60 70 80 90 100
QKNGFKIFLD LKLYDIPNTI KKTIFSLAKF GIWMVNVHAS GGYNMMTAAK
110 120 130 140 150
DALSHINNPP KLIAVTVLTS MEKSDLSKSK IFTKIINHVI HLSNNAYKCG
160 170 180 190 200
LDGIVCSPWE AEKVRKKFGN NFIIVTPGIR FKNTNYNDQK RVMNPYDAIK
210 220 230
SGSNYIVIGR PITKSSNPYL LLEKILSKLN NI
Length:232
Mass (Da):26,131
Last modified:March 1, 2003 - v1
Checksum:i326681AB3EB88AFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000021 Genomic DNA. Translation: BAC24509.1.
RefSeqiWP_011070167.1. NC_004344.2.

Genome annotation databases

EnsemblBacteriaiBAC24509; BAC24509; BAC24509.
KEGGiwbr:pyrF.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPYRF_WIGBR
AccessioniPrimary (citable) accession number: Q8D2J1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: March 1, 2003
Last modified: June 7, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families