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Protein

Alanine racemase

Gene

alr

Organism
Wigglesworthia glossinidia brevipalpis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei130 – 1301SubstrateUniRule annotation
Active sitei253 – 2531Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei302 – 3021Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr
Synonyms:dadX
Ordered Locus Names:WIGBR3760
OrganismiWigglesworthia glossinidia brevipalpis
Taxonomic identifieri36870 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia
ProteomesiUP000000562 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Alanine racemasePRO_0000114597Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiQ8D2H8.

Interactioni

Protein-protein interaction databases

STRINGi36870.WGLp376.

Structurei

3D structure databases

ProteinModelPortaliQ8D2H8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
KOiK01775.
OMAiSGAAMYH.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8D2H8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRKTTIRIS SNALASNLRT IKNYANKSKV WSVIKSNAYG HTIKAALKGL
60 70 80 90 100
KETSGFAVLE LNEAVLLREN GWNGPILLLE GFFEESDLLE ICQYKITTVI
110 120 130 140 150
HNDWQLNYIK QYDIKSPIDV YLKLNSGMNR LGFNEKDFIR TWYDLSNLKK
160 170 180 190 200
ISSLTLMSHF SLGFSTKTVN KQMNIIRKIF KILNPTLCLA NSTAIIFHTY
210 220 230 240 250
THKDWIRPGI ILYGILPKEN KKISKKFNLK PVMTLESRII SIQNIKSKEY
260 270 280 290 300
IGYGKNYYSN KSNLIGIVSC GYADGYPFSV PFSGTPVFVN GTRTQIIGSV
310 320 330 340 350
CMDMLTIDLN DCPNAKIGSK VELWGNNISI NEISKLANTT SYELMCRISS

RVLVKIE
Length:357
Mass (Da):40,471
Last modified:March 1, 2003 - v1
Checksum:i7C5A3DACF7FF0323
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000021 Genomic DNA. Translation: BAC24522.1.
RefSeqiNP_871379.1. NC_004344.2.
WP_011070180.1. NC_004344.2.

Genome annotation databases

EnsemblBacteriaiBAC24522; BAC24522; BAC24522.
KEGGiwbr:WGLp376.
PATRICi24024958. VBIWigGlo15804_0409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000021 Genomic DNA. Translation: BAC24522.1.
RefSeqiNP_871379.1. NC_004344.2.
WP_011070180.1. NC_004344.2.

3D structure databases

ProteinModelPortaliQ8D2H8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi36870.WGLp376.

Proteomic databases

PRIDEiQ8D2H8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC24522; BAC24522; BAC24522.
KEGGiwbr:WGLp376.
PATRICi24024958. VBIWigGlo15804_0409.

Phylogenomic databases

eggNOGiCOG0787.
KOiK01775.
OMAiSGAAMYH.
OrthoDBiEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
    Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
    Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiALR_WIGBR
AccessioniPrimary (citable) accession number: Q8D2H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: March 1, 2003
Last modified: May 27, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.