Q8D2H8 (ALR_WIGBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alanine racemase
EC=5.1.1.1

Gene names

Name:	alr
Synonyms:	dadX
Ordered Locus Names:	WIGBR3760

Organism

Wigglesworthia glossinidia brevipalpis [Complete proteome] [HAMAP]

Taxonomic identifier

36870 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Wigglesworthia › Wigglesworthia glossinidia

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201
Catalytic activity	L-alanine = D-alanine. HAMAP-Rule MF_01201
Cofactor	Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201
Sequence similarities	Belongs to the alanine racemase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	D-alanine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	alanine racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	Alanine racemase HAMAP-Rule MF_01201		PRO_0000114597
Sites
	Active site	35	1	Proton acceptor; specific for D-alanine By similarity
	Active site	253	1	Proton acceptor; specific for L-alanine By similarity
	Binding site	130	1	Substrate By similarity
	Binding site	302	1	Substrate; via amide nitrogen By similarity
Amino acid modifications
	Modified residue	35	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8D2H8 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 7C5A3DACF7FF0323	FASTA	357	40,471
	10 20 30 40 50 60 MPRKTTIRIS SNALASNLRT IKNYANKSKV WSVIKSNAYG HTIKAALKGL KETSGFAVLE 70 80 90 100 110 120 LNEAVLLREN GWNGPILLLE GFFEESDLLE ICQYKITTVI HNDWQLNYIK QYDIKSPIDV 130 140 150 160 170 180 YLKLNSGMNR LGFNEKDFIR TWYDLSNLKK ISSLTLMSHF SLGFSTKTVN KQMNIIRKIF 190 200 210 220 230 240 KILNPTLCLA NSTAIIFHTY THKDWIRPGI ILYGILPKEN KKISKKFNLK PVMTLESRII 250 260 270 280 290 300 SIQNIKSKEY IGYGKNYYSN KSNLIGIVSC GYADGYPFSV PFSGTPVFVN GTRTQIIGSV 310 320 330 340 350 CMDMLTIDLN DCPNAKIGSK VELWGNNISI NEISKLANTT SYELMCRISS RVLVKIE

References

[1]	"Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia." Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S. Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000021 Genomic DNA. Translation: BAC24522.1.
RefSeq	NP_871379.1. NC_004344.2.
3D structure databases
ProteinModelPortal	Q8D2H8.
ModBase	Search...
Protein-protein interaction databases
STRING	36870.WGLp376.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAC24522; BAC24522; BAC24522.
GeneID	1257183.
KEGG	wbr:WGLp376.
PATRIC	24024958. VBIWigGlo15804_0409.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0787.
KO	K01775.
OMA	IARIEEY.
Enzyme and pathway databases
UniPathway	UPA00042; UER00497.
Family and domain databases
Gene3D	2.40.37.10. 1 hit.
HAMAP	MF_01201. Ala_racemase.
InterPro	IPR000821. Ala_racemase. IPR009006. Ala_racemase/Decarboxylase_C. IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. [Graphical view]
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
SMART	SM01005. Ala_racemase_C. 1 hit. [Graphical view]
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMs	TIGR00492. alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALR_WIGBR

Accession

Primary (citable) accession number: Q8D2H8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2003
Last sequence update:	March 1, 2003
Last modified:	May 29, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program