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Q8D2H8

- ALR_WIGBR

UniProt

Q8D2H8 - ALR_WIGBR

Protein

Alanine racemase

Gene

alr

Organism
Wigglesworthia glossinidia brevipalpis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei130 – 1301SubstrateUniRule annotation
    Active sitei253 – 2531Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei302 – 3021Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alr
    Synonyms:dadX
    Ordered Locus Names:WIGBR3760
    OrganismiWigglesworthia glossinidia brevipalpis
    Taxonomic identifieri36870 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia
    ProteomesiUP000000562: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 357357Alanine racemasePRO_0000114597Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiQ8D2H8.

    Interactioni

    Protein-protein interaction databases

    STRINGi36870.WGLp376.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8D2H8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    KOiK01775.
    OMAiSRLGLWH.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8D2H8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRKTTIRIS SNALASNLRT IKNYANKSKV WSVIKSNAYG HTIKAALKGL    50
    KETSGFAVLE LNEAVLLREN GWNGPILLLE GFFEESDLLE ICQYKITTVI 100
    HNDWQLNYIK QYDIKSPIDV YLKLNSGMNR LGFNEKDFIR TWYDLSNLKK 150
    ISSLTLMSHF SLGFSTKTVN KQMNIIRKIF KILNPTLCLA NSTAIIFHTY 200
    THKDWIRPGI ILYGILPKEN KKISKKFNLK PVMTLESRII SIQNIKSKEY 250
    IGYGKNYYSN KSNLIGIVSC GYADGYPFSV PFSGTPVFVN GTRTQIIGSV 300
    CMDMLTIDLN DCPNAKIGSK VELWGNNISI NEISKLANTT SYELMCRISS 350
    RVLVKIE 357
    Length:357
    Mass (Da):40,471
    Last modified:March 1, 2003 - v1
    Checksum:i7C5A3DACF7FF0323
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000021 Genomic DNA. Translation: BAC24522.1.
    RefSeqiNP_871379.1. NC_004344.2.

    Genome annotation databases

    EnsemblBacteriaiBAC24522; BAC24522; BAC24522.
    GeneIDi1257183.
    KEGGiwbr:WGLp376.
    PATRICi24024958. VBIWigGlo15804_0409.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000021 Genomic DNA. Translation: BAC24522.1 .
    RefSeqi NP_871379.1. NC_004344.2.

    3D structure databases

    ProteinModelPortali Q8D2H8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36870.WGLp376.

    Proteomic databases

    PRIDEi Q8D2H8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC24522 ; BAC24522 ; BAC24522 .
    GeneIDi 1257183.
    KEGGi wbr:WGLp376.
    PATRICi 24024958. VBIWigGlo15804_0409.

    Phylogenomic databases

    eggNOGi COG0787.
    KOi K01775.
    OMAi SRLGLWH.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
      Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
      Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiALR_WIGBR
    AccessioniPrimary (citable) accession number: Q8D2H8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3