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Q8D2H8 (ALR_WIGBR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase

EC=5.1.1.1
Gene names
Name:alr
Synonyms:dadX
Ordered Locus Names:WIGBR3760
OrganismWigglesworthia glossinidia brevipalpis [Complete proteome] [HAMAP]
Taxonomic identifier36870 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-alanine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionalanine racemase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 357357Alanine racemase HAMAP-Rule MF_01201
PRO_0000114597

Sites

Active site351Proton acceptor; specific for D-alanine By similarity
Active site2531Proton acceptor; specific for L-alanine By similarity
Binding site1301Substrate By similarity
Binding site3021Substrate; via amide nitrogen By similarity

Amino acid modifications

Modified residue351N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8D2H8 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 7C5A3DACF7FF0323

FASTA35740,471
        10         20         30         40         50         60 
MPRKTTIRIS SNALASNLRT IKNYANKSKV WSVIKSNAYG HTIKAALKGL KETSGFAVLE 

        70         80         90        100        110        120 
LNEAVLLREN GWNGPILLLE GFFEESDLLE ICQYKITTVI HNDWQLNYIK QYDIKSPIDV 

       130        140        150        160        170        180 
YLKLNSGMNR LGFNEKDFIR TWYDLSNLKK ISSLTLMSHF SLGFSTKTVN KQMNIIRKIF 

       190        200        210        220        230        240 
KILNPTLCLA NSTAIIFHTY THKDWIRPGI ILYGILPKEN KKISKKFNLK PVMTLESRII 

       250        260        270        280        290        300 
SIQNIKSKEY IGYGKNYYSN KSNLIGIVSC GYADGYPFSV PFSGTPVFVN GTRTQIIGSV 

       310        320        330        340        350 
CMDMLTIDLN DCPNAKIGSK VELWGNNISI NEISKLANTT SYELMCRISS RVLVKIE 

« Hide

References

[1]"Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000021 Genomic DNA. Translation: BAC24522.1.
RefSeqNP_871379.1. NC_004344.2.

3D structure databases

ProteinModelPortalQ8D2H8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING36870.WGLp376.

Proteomic databases

PRIDEQ8D2H8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC24522; BAC24522; BAC24522.
GeneID1257183.
KEGGwbr:WGLp376.
PATRIC24024958. VBIWigGlo15804_0409.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
KOK01775.
OMASRLGLWH.
OrthoDBEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameALR_WIGBR
AccessionPrimary (citable) accession number: Q8D2H8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways