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Q8D2H4 (LPXB_WIGBR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:WIGBR3800
OrganismWigglesworthia glossinidia brevipalpis [Complete proteome] [HAMAP]
Taxonomic identifier36870 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia

Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 385385Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000190192

Sequences

Sequence LengthMass (Da)Tools
Q8D2H4 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: B74D5F093A7B79F8

FASTA38544,058
        10         20         30         40         50         60 
MKNILIGIVA GEASGDFLGA ELIKSLNIIH SNIKFVGIAG PLMLKEKNVE SWFSIEELSI 

        70         80         90        100        110        120 
MGIFEIINRI PKILNIRNKI FNRLSFLKPD LFIGIDSPEF NIHLEFKLKK NGIKIIHYVS 

       130        140        150        160        170        180 
PSIWAWRKSR IFKIKESVDK VLALLPFEKK IYDDFNIPCK FVGHPLADKI PLYPDKYSIR 

       190        200        210        220        230        240 
SNLEIDKNSV CLALLPGSRL TEINLLSKKF LYAAKIIKKN IFNLKILVPM VNSLLKKRFE 

       250        260        270        280        290        300 
EIKREVAPDL PITIFDNFSY EVMACSDFSI VTSGTATLEC MLSKCPMVVG YCMKKINFFL 

       310        320        330        340        350        360 
LKKIIKINYI SLPNLIAGKK IVPEKIQNEC NPEVLAKEIL IIFNDKKKYK KTKKIFYKLH 

       370        380 
KKIRCNSSYN AACSASCLIN KLTIK 

« Hide

References

[1]"Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000021 Genomic DNA. Translation: BAC24526.1.
RefSeqNP_871383.1. NC_004344.2.

3D structure databases

ProteinModelPortalQ8D2H4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING36870.WGLp380.

Protein family/group databases

CAZyGT19. Glycosyltransferase Family 19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC24526; BAC24526; BAC24526.
GeneID1257187.
KEGGwbr:WGLp380.
PATRIC24024966. VBIWigGlo15804_0413.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0763.
KOK00748.
OMAYIAPQEW.
OrthoDBEOG6FBWZR.

Enzyme and pathway databases

UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_WIGBR
AccessionPrimary (citable) accession number: Q8D2H4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways