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Q8D2H4

- LPXB_WIGBR

UniProt

Q8D2H4 - LPXB_WIGBR

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, WIGBR3800
Organism
Wigglesworthia glossinidia brevipalpis
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:WIGBR3800
OrganismiWigglesworthia glossinidia brevipalpis
Taxonomic identifieri36870 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia
ProteomesiUP000000562: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Lipid-A-disaccharide synthaseUniRule annotation
PRO_0000190192Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi36870.WGLp380.

Structurei

3D structure databases

ProteinModelPortaliQ8D2H4.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8D2H4-1 [UniParc]FASTAAdd to Basket

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MKNILIGIVA GEASGDFLGA ELIKSLNIIH SNIKFVGIAG PLMLKEKNVE    50
SWFSIEELSI MGIFEIINRI PKILNIRNKI FNRLSFLKPD LFIGIDSPEF 100
NIHLEFKLKK NGIKIIHYVS PSIWAWRKSR IFKIKESVDK VLALLPFEKK 150
IYDDFNIPCK FVGHPLADKI PLYPDKYSIR SNLEIDKNSV CLALLPGSRL 200
TEINLLSKKF LYAAKIIKKN IFNLKILVPM VNSLLKKRFE EIKREVAPDL 250
PITIFDNFSY EVMACSDFSI VTSGTATLEC MLSKCPMVVG YCMKKINFFL 300
LKKIIKINYI SLPNLIAGKK IVPEKIQNEC NPEVLAKEIL IIFNDKKKYK 350
KTKKIFYKLH KKIRCNSSYN AACSASCLIN KLTIK 385
Length:385
Mass (Da):44,058
Last modified:March 1, 2003 - v1
Checksum:iB74D5F093A7B79F8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000021 Genomic DNA. Translation: BAC24526.1.
RefSeqiNP_871383.1. NC_004344.2.

Genome annotation databases

EnsemblBacteriaiBAC24526; BAC24526; BAC24526.
GeneIDi1257187.
KEGGiwbr:WGLp380.
PATRICi24024966. VBIWigGlo15804_0413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000021 Genomic DNA. Translation: BAC24526.1 .
RefSeqi NP_871383.1. NC_004344.2.

3D structure databases

ProteinModelPortali Q8D2H4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36870.WGLp380.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC24526 ; BAC24526 ; BAC24526 .
GeneIDi 1257187.
KEGGi wbr:WGLp380.
PATRICi 24024966. VBIWigGlo15804_0413.

Phylogenomic databases

eggNOGi COG0763.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
    Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
    Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiLPXB_WIGBR
AccessioniPrimary (citable) accession number: Q8D2H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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