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Q8D2H4

- LPXB_WIGBR

UniProt

Q8D2H4 - LPXB_WIGBR

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Wigglesworthia glossinidia brevipalpis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:WIGBR3800
    OrganismiWigglesworthia glossinidia brevipalpis
    Taxonomic identifieri36870 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia
    ProteomesiUP000000562: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 385385Lipid-A-disaccharide synthasePRO_0000190192Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi36870.WGLp380.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8D2H4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8D2H4-1 [UniParc]FASTAAdd to Basket

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    MKNILIGIVA GEASGDFLGA ELIKSLNIIH SNIKFVGIAG PLMLKEKNVE    50
    SWFSIEELSI MGIFEIINRI PKILNIRNKI FNRLSFLKPD LFIGIDSPEF 100
    NIHLEFKLKK NGIKIIHYVS PSIWAWRKSR IFKIKESVDK VLALLPFEKK 150
    IYDDFNIPCK FVGHPLADKI PLYPDKYSIR SNLEIDKNSV CLALLPGSRL 200
    TEINLLSKKF LYAAKIIKKN IFNLKILVPM VNSLLKKRFE EIKREVAPDL 250
    PITIFDNFSY EVMACSDFSI VTSGTATLEC MLSKCPMVVG YCMKKINFFL 300
    LKKIIKINYI SLPNLIAGKK IVPEKIQNEC NPEVLAKEIL IIFNDKKKYK 350
    KTKKIFYKLH KKIRCNSSYN AACSASCLIN KLTIK 385
    Length:385
    Mass (Da):44,058
    Last modified:March 1, 2003 - v1
    Checksum:iB74D5F093A7B79F8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000021 Genomic DNA. Translation: BAC24526.1.
    RefSeqiNP_871383.1. NC_004344.2.

    Genome annotation databases

    EnsemblBacteriaiBAC24526; BAC24526; BAC24526.
    GeneIDi1257187.
    KEGGiwbr:WGLp380.
    PATRICi24024966. VBIWigGlo15804_0413.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000021 Genomic DNA. Translation: BAC24526.1 .
    RefSeqi NP_871383.1. NC_004344.2.

    3D structure databases

    ProteinModelPortali Q8D2H4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36870.WGLp380.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC24526 ; BAC24526 ; BAC24526 .
    GeneIDi 1257187.
    KEGGi wbr:WGLp380.
    PATRICi 24024966. VBIWigGlo15804_0413.

    Phylogenomic databases

    eggNOGi COG0763.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
      Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
      Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiLPXB_WIGBR
    AccessioniPrimary (citable) accession number: Q8D2H4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3