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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Wigglesworthia glossinidia brevipalpis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:WIGBR3800
OrganismiWigglesworthia glossinidia brevipalpis
Taxonomic identifieri36870 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia
ProteomesiUP000000562: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Lipid-A-disaccharide synthasePRO_0000190192Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi36870.WGLp380.

Structurei

3D structure databases

ProteinModelPortaliQ8D2H4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
KOiK00748.
OMAiQPWVGLP.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8D2H4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNILIGIVA GEASGDFLGA ELIKSLNIIH SNIKFVGIAG PLMLKEKNVE
60 70 80 90 100
SWFSIEELSI MGIFEIINRI PKILNIRNKI FNRLSFLKPD LFIGIDSPEF
110 120 130 140 150
NIHLEFKLKK NGIKIIHYVS PSIWAWRKSR IFKIKESVDK VLALLPFEKK
160 170 180 190 200
IYDDFNIPCK FVGHPLADKI PLYPDKYSIR SNLEIDKNSV CLALLPGSRL
210 220 230 240 250
TEINLLSKKF LYAAKIIKKN IFNLKILVPM VNSLLKKRFE EIKREVAPDL
260 270 280 290 300
PITIFDNFSY EVMACSDFSI VTSGTATLEC MLSKCPMVVG YCMKKINFFL
310 320 330 340 350
LKKIIKINYI SLPNLIAGKK IVPEKIQNEC NPEVLAKEIL IIFNDKKKYK
360 370 380
KTKKIFYKLH KKIRCNSSYN AACSASCLIN KLTIK
Length:385
Mass (Da):44,058
Last modified:March 1, 2003 - v1
Checksum:iB74D5F093A7B79F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000021 Genomic DNA. Translation: BAC24526.1.
RefSeqiNP_871383.1. NC_004344.2.

Genome annotation databases

EnsemblBacteriaiBAC24526; BAC24526; BAC24526.
GeneIDi1257187.
KEGGiwbr:WGLp380.
PATRICi24024966. VBIWigGlo15804_0413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000021 Genomic DNA. Translation: BAC24526.1.
RefSeqiNP_871383.1. NC_004344.2.

3D structure databases

ProteinModelPortaliQ8D2H4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi36870.WGLp380.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC24526; BAC24526; BAC24526.
GeneIDi1257187.
KEGGiwbr:WGLp380.
PATRICi24024966. VBIWigGlo15804_0413.

Phylogenomic databases

eggNOGiCOG0763.
KOiK00748.
OMAiQPWVGLP.
OrthoDBiEOG6FBWZR.

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
    Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
    Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiLPXB_WIGBR
AccessioniPrimary (citable) accession number: Q8D2H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.