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Q8D2A6

- PANC_WIGBR

UniProt

Q8D2A6 - PANC_WIGBR

Protein

Pantothenate synthetase

Gene

panC

Organism
Wigglesworthia glossinidia brevipalpis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei38 – 381Proton donorUniRule annotation
    Binding sitei62 – 621Beta-alanineUniRule annotation
    Binding sitei62 – 621PantoateUniRule annotation
    Binding sitei156 – 1561PantoateUniRule annotation
    Binding sitei179 – 1791ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi31 – 388ATPUniRule annotation
    Nucleotide bindingi150 – 1534ATPUniRule annotation
    Nucleotide bindingi187 – 1904ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Gene namesi
    Name:panCUniRule annotation
    Ordered Locus Names:WIGBR4480
    OrganismiWigglesworthia glossinidia brevipalpis
    Taxonomic identifieri36870 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia
    ProteomesiUP000000562: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Pantothenate synthetasePRO_0000305575Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi36870.WGLp448.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8D2A6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    KOiK01918.
    OMAiHAGHMEL.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8D2A6-1 [UniParc]FASTAAdd to Basket

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    MLIIKKSSEL TCVIKNLKKK NKSKIALIPT MGNLHRGHLE LIKIGKLKSN    50
    ILIISIFINP AQFSNSKDFR NYPKTLNEDI KKLIEYKVDI LFCPTLKSMY 100
    PFGYKNHTLV NVVQYSSILD GKTMSNHFIG VATIISKLFN LINPDIAIFG 150
    QKDFQQLIMI RQLVLHMNYN IKILSAPIIR CFDGLALSSR NRHLSLEERK 200
    KAPKIYNILL ELSKKIKLNK LYNLKKDYDA ILKNYLIKLN NYGFKVEVLS 250
    IRNAKNLMPI DENSKQAVIL CSAKIGSIRL VDNIKIKL 288
    Length:288
    Mass (Da):33,075
    Last modified:March 1, 2003 - v1
    Checksum:iE63025EB2166C4DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000021 Genomic DNA. Translation: BAC24594.1.
    RefSeqiNP_871451.1. NC_004344.2.

    Genome annotation databases

    EnsemblBacteriaiBAC24594; BAC24594; BAC24594.
    GeneIDi1257258.
    KEGGiwbr:WGLp448.
    PATRICi24025114. VBIWigGlo15804_0484.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000021 Genomic DNA. Translation: BAC24594.1 .
    RefSeqi NP_871451.1. NC_004344.2.

    3D structure databases

    ProteinModelPortali Q8D2A6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36870.WGLp448.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC24594 ; BAC24594 ; BAC24594 .
    GeneIDi 1257258.
    KEGGi wbr:WGLp448.
    PATRICi 24025114. VBIWigGlo15804_0484.

    Phylogenomic databases

    eggNOGi COG0414.
    KOi K01918.
    OMAi HAGHMEL.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
      Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
      Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiPANC_WIGBR
    AccessioniPrimary (citable) accession number: Q8D2A6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3