Q8D281 (UPPP_WIGBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Synonyms:	bacA, upk
Ordered Locus Names:	WIGBR4730

Organism

Wigglesworthia glossinidia brevipalpis [Complete proteome] [HAMAP]

Taxonomic identifier

36870 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Wigglesworthia › Wigglesworthia glossinidia

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000151239
Regions
	Transmembrane	4 – 24	21	Helical; Potential
	Transmembrane	41 – 61	21	Helical; Potential
	Transmembrane	84 – 104	21	Helical; Potential
	Transmembrane	116 – 136	21	Helical; Potential
	Transmembrane	160 – 180	21	Helical; Potential
	Transmembrane	185 – 205	21	Helical; Potential
	Transmembrane	216 – 236	21	Helical; Potential
	Transmembrane	246 – 266	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8D281 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 9662E97CAAFD2ED8	FASTA	267	30,959
	10 20 30 40 50 60 MKEILIIIIL GIVEGITEFF PISSNGHLIL INYIFNIDKE NIQNIIKIIQ IGPIFSIILL 70 80 90 100 110 120 FKEKIKKSIT FFYFNINNIK KKLILILFNL VLSCIPISIL GFMFYKKLEE FYSPKYISYF 130 140 150 160 170 180 LILGSIFFIL SEFISLKKIK IDNFKKISFL KYFIIGSSQC FSLLPGVSRL GITISIGLIL 190 200 210 220 230 240 NIDRYVLFKF SMILFSSIMP AVLILEVYKN FFYLKENIFF VIIGVMSSFL TSLIFGRTAI 250 260 KIMKNTSLII FAIYRIFIAC IILFTCN

References

[1]	"Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia." Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S. Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000021 Genomic DNA. Translation: BAC24619.1.
RefSeq	NP_871476.1. NC_004344.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	36870.WGLp473.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAC24619; BAC24619; BAC24619.
GeneID	1257284.
KEGG	wbr:WGLp473.
PATRIC	24025168. VBIWigGlo15804_0510.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
KO	K06153.
OMA	NMFEYVI.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP_WIGBR

Accession

Primary (citable) accession number: Q8D281

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program