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Q8D281 (UPPP_WIGBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:WIGBR4730
OrganismWigglesworthia glossinidia brevipalpis [Complete proteome] [HAMAP]
Taxonomic identifier36870 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151239

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane41 – 6121Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane116 – 13621Helical; Potential
Transmembrane160 – 18021Helical; Potential
Transmembrane185 – 20521Helical; Potential
Transmembrane216 – 23621Helical; Potential
Transmembrane246 – 26621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q8D281 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 9662E97CAAFD2ED8

FASTA26730,959
        10         20         30         40         50         60 
MKEILIIIIL GIVEGITEFF PISSNGHLIL INYIFNIDKE NIQNIIKIIQ IGPIFSIILL 

        70         80         90        100        110        120 
FKEKIKKSIT FFYFNINNIK KKLILILFNL VLSCIPISIL GFMFYKKLEE FYSPKYISYF 

       130        140        150        160        170        180 
LILGSIFFIL SEFISLKKIK IDNFKKISFL KYFIIGSSQC FSLLPGVSRL GITISIGLIL 

       190        200        210        220        230        240 
NIDRYVLFKF SMILFSSIMP AVLILEVYKN FFYLKENIFF VIIGVMSSFL TSLIFGRTAI 

       250        260 
KIMKNTSLII FAIYRIFIAC IILFTCN 

« Hide

References

[1]"Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000021 Genomic DNA. Translation: BAC24619.1.
RefSeqNP_871476.1. NC_004344.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING36870.WGLp473.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC24619; BAC24619; BAC24619.
GeneID1257284.
KEGGwbr:WGLp473.
PATRIC24025168. VBIWigGlo15804_0510.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
KOK06153.
OMAWRKISSS.
OrthoDBEOG6QP13M.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_WIGBR
AccessionPrimary (citable) accession number: Q8D281
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families