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Q8D281

- UPPP_WIGBR

UniProt

Q8D281 - UPPP_WIGBR

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, bacA, upk, WIGBR4730
Organism
Wigglesworthia glossinidia brevipalpis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:WIGBR4730
OrganismiWigglesworthia glossinidia brevipalpis
Taxonomic identifieri36870 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia
ProteomesiUP000000562: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421Helical; Reviewed prediction
Add
BLAST
Transmembranei41 – 6121Helical; Reviewed prediction
Add
BLAST
Transmembranei84 – 10421Helical; Reviewed prediction
Add
BLAST
Transmembranei116 – 13621Helical; Reviewed prediction
Add
BLAST
Transmembranei160 – 18021Helical; Reviewed prediction
Add
BLAST
Transmembranei185 – 20521Helical; Reviewed prediction
Add
BLAST
Transmembranei216 – 23621Helical; Reviewed prediction
Add
BLAST
Transmembranei246 – 26621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Undecaprenyl-diphosphataseUniRule annotation
PRO_0000151239Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi36870.WGLp473.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
KOiK06153.
OMAiWRKISSS.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8D281-1 [UniParc]FASTAAdd to Basket

« Hide

MKEILIIIIL GIVEGITEFF PISSNGHLIL INYIFNIDKE NIQNIIKIIQ    50
IGPIFSIILL FKEKIKKSIT FFYFNINNIK KKLILILFNL VLSCIPISIL 100
GFMFYKKLEE FYSPKYISYF LILGSIFFIL SEFISLKKIK IDNFKKISFL 150
KYFIIGSSQC FSLLPGVSRL GITISIGLIL NIDRYVLFKF SMILFSSIMP 200
AVLILEVYKN FFYLKENIFF VIIGVMSSFL TSLIFGRTAI KIMKNTSLII 250
FAIYRIFIAC IILFTCN 267
Length:267
Mass (Da):30,959
Last modified:March 1, 2003 - v1
Checksum:i9662E97CAAFD2ED8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000021 Genomic DNA. Translation: BAC24619.1.
RefSeqiNP_871476.1. NC_004344.2.

Genome annotation databases

EnsemblBacteriaiBAC24619; BAC24619; BAC24619.
GeneIDi1257284.
KEGGiwbr:WGLp473.
PATRICi24025168. VBIWigGlo15804_0510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000021 Genomic DNA. Translation: BAC24619.1 .
RefSeqi NP_871476.1. NC_004344.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36870.WGLp473.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC24619 ; BAC24619 ; BAC24619 .
GeneIDi 1257284.
KEGGi wbr:WGLp473.
PATRICi 24025168. VBIWigGlo15804_0510.

Phylogenomic databases

eggNOGi COG1968.
KOi K06153.
OMAi WRKISSS.
OrthoDBi EOG6QP13M.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
    Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
    Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiUPPP_WIGBR
AccessioniPrimary (citable) accession number: Q8D281
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3