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Q8D244 (PUR9_WIGBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:WIGBR5110
OrganismWigglesworthia glossinidia brevipalpis [Complete proteome] [HAMAP]
Taxonomic identifier36870 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 529529Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_0000192153

Sequences

Sequence LengthMass (Da)Tools
Q8D244 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 2F4894D9659C30B2

FASTA52959,775
        10         20         30         40         50         60 
MEQSFLPIRC ALISVSDKTG IFSLAKNLIK HKVKLITTSG TYKYLLEKGI FSTSVSEYIN 

        70         80         90        100        110        120 
HPEIINGRVK TLHPKIHGGI LSNNKNINEN KNLNIKKIDM VITNFYPFKK KVKKENIKIE 

       130        140        150        160        170        180 
NIIDNIDIGG VALARSAAKN YKYVTVVVNI NQYSKLSSEM DKNSGSVSFK TRFYFSTLAF 

       190        200        210        220        230        240 
QYSYSYDKEI FNYFNKIYFK EIELKKNLKN KKFPELFSIS FSKKEDVLYG ENYHQKAAFY 

       250        260        270        280        290        300 
TDPVIHPGTV PFSIQRQGKK LSYNNIVDSD IAINCVMNFS EIACVIVKHS TPCGVSSGKN 

       310        320        330        340        350        360 
IIDAYRSAYY SDPDSAFGGI ISFNRPLTIE AAEFIINKQF VEIIIAPVIE KDALLTLKSK 

       370        380        390        400        410        420 
SKIIVLECGY LSKNFLLNFK KVNCGLLLQD SDNKILKEKD IKIVSKRQPS KLEIESSIFI 

       430        440        450        460        470        480 
WKIIKFIKSN AIIYGKNKRT LGIGSGQTSR IFSTRIAAYK AIDQGFSLKG SVMASDAFFP 

       490        500        510        520 
FRDSIDFASK FGVSCIIQPG GSINDDKIIS AVDENNMSMI FTNTRQFSH 

« Hide

References

[1]"Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000021 Genomic DNA. Translation: BAC24657.1.
RefSeqNP_871514.1. NC_004344.2.

3D structure databases

ProteinModelPortalQ8D244.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING36870.WGLp511.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC24657; BAC24657; BAC24657.
GeneID1257322.
KEGGwbr:WGLp511.
PATRIC24025250. VBIWigGlo15804_0551.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
KOK00602.
OMARAFKTDP.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_WIGBR
AccessionPrimary (citable) accession number: Q8D244
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways