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Q8D1X5 (SYW_WIGBR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:WIGBR5810
OrganismWigglesworthia glossinidia brevipalpis [Complete proteome] [HAMAP]
Taxonomic identifier36870 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136710

Regions

Motif13 – 219"HIGH" region HAMAP-Rule MF_00140
Motif196 – 2005"KMSKS" region HAMAP-Rule MF_00140

Sites

Binding site1991ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8D1X5 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 84AB4EB47F9DEBDF

FASTA33438,377
        10         20         30         40         50         60 
MIKKLNIFSG MQPSGIPTLG NYIGVLRQWK ILQKIYNSIY CIADLHYLTN NKENSKILFK 

        70         80         90        100        110        120 
RSLDLLAIYL ACDIDPNESV IFLQSHIPEH SQLSWILNCY TYFGELTRMV QFKEKIKNKK 

       130        140        150        160        170        180 
NINLGLLSYP VLMASDILLY QTDIVPVGKD QIQHLELSRT IARRFNKLHG DVFIIPEKII 

       190        200        210        220        230        240 
SKTGSKIMSL SNPNKKMSKS NLNRNNFISL LDQPYSIIEK IKNAKTDSDN PPKINFDIIK 

       250        260        270        280        290        300 
KPGISNLLSI ISELRGINIK DLEISFKNKS YKYLKNEVTG AVLEHLKILQ KKYFLIRKDE 

       310        320        330 
KYLINILKSG SKKAKKIARG TLKKVNESIG LLNF 

« Hide

References

[1]"Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000021 Genomic DNA. Translation: BAC24727.1.
RefSeqNP_871584.1. NC_004344.2.

3D structure databases

ProteinModelPortalQ8D1X5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING36870.WGLp581.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC24727; BAC24727; BAC24727.
GeneID1257397.
KEGGwbr:WGLp581.
PATRIC24025406. VBIWigGlo15804_0624.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0180.
KOK01867.
OMAFAFYLAC.
OrthoDBEOG686NJQ.
ProtClustDBPRK00927.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYW_WIGBR
AccessionPrimary (citable) accession number: Q8D1X5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries