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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Wigglesworthia glossinidia brevipalpis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei136L-tryptophanUniRule annotation1
Binding sitei187ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 14ATPUniRule annotation3
Nucleotide bindingi20 – 21ATPUniRule annotation2
Nucleotide bindingi148 – 150ATPUniRule annotation3
Nucleotide bindingi196 – 200ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:WIGBR5810
OrganismiWigglesworthia glossinidia brevipalpis
Taxonomic identifieri36870 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeWigglesworthia
Proteomesi
  • UP000000562 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367101 – 334Tryptophan--tRNA ligaseAdd BLAST334

Proteomic databases

PRIDEiQ8D1X5

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi36870.WGLp581

Structurei

3D structure databases

ProteinModelPortaliQ8D1X5
SMRiQ8D1X5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi13 – 21"HIGH" regionUniRule annotation9
Motifi196 – 200"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
KOiK01867
OMAiQRMTQFK
OrthoDBiPOG091H00I9

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8D1X5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKKLNIFSG MQPSGIPTLG NYIGVLRQWK ILQKIYNSIY CIADLHYLTN
60 70 80 90 100
NKENSKILFK RSLDLLAIYL ACDIDPNESV IFLQSHIPEH SQLSWILNCY
110 120 130 140 150
TYFGELTRMV QFKEKIKNKK NINLGLLSYP VLMASDILLY QTDIVPVGKD
160 170 180 190 200
QIQHLELSRT IARRFNKLHG DVFIIPEKII SKTGSKIMSL SNPNKKMSKS
210 220 230 240 250
NLNRNNFISL LDQPYSIIEK IKNAKTDSDN PPKINFDIIK KPGISNLLSI
260 270 280 290 300
ISELRGINIK DLEISFKNKS YKYLKNEVTG AVLEHLKILQ KKYFLIRKDE
310 320 330
KYLINILKSG SKKAKKIARG TLKKVNESIG LLNF
Length:334
Mass (Da):38,377
Last modified:March 1, 2003 - v1
Checksum:i84AB4EB47F9DEBDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000021 Genomic DNA Translation: BAC24727.1

Genome annotation databases

EnsemblBacteriaiBAC24727; BAC24727; BAC24727
KEGGiwbr:trpS

Similar proteinsi

Entry informationi

Entry nameiSYW_WIGBR
AccessioniPrimary (citable) accession number: Q8D1X5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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