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Q8CY50 (MURG_BIFLO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
EC=2.4.1.227
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene names
Name:murG
Ordered Locus Names:BL1323
OrganismBifidobacterium longum (strain NCC 2705)
Taxonomic identifier206672 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity. HAMAP MF_00033

Catalytic activity

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00033

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00033

Subcellular location

Cell membrane; Peripheral membrane protein By similarity HAMAP MF_00033.

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 393393UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase HAMAP MF_00033
PRO_0000109145

Sequences

Sequence LengthMass (Da)Tools
Q8CY50 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: DAF16113F5923AAD

FASTA39341,511
        10         20         30         40         50         60 
MNQGTPHIVL AGGGTAGHVN PLLAVAGAIR DIEPTAQVTV IGTAVGLEKD LVPEAGYELD 

        70         80         90        100        110        120 
TIEKVPFPRR PNLYMLRFPA KWKRETAKVR SILETRHADV VAGFGGYASA PVYATAHKMG 

       130        140        150        160        170        180 
IPIAIHEQNA RAGMANKLGA RWADFIGTVY EGTGLKPRAG ADVERVGLPL RPAIASLTKR 

       190        200        210        220        230        240 
IGDDRAAVRR ESAAQLGVDP NRPLVLVTGG SLGAQSLNRA IASSAADLLA HAQIIHLTGR 

       250        260        270        280        290        300 
GKISEVRELV TASAGADVLT GIGPESAGQG DYHTAEYLER IDLAFACADL VICRAGAGSV 

       310        320        330        340        350        360 
SELAALGLPA IYVPLPIGNG EQRFNAEPVV NAGGGLLVAD KDLTPQWVHE HVPDLLADHE 

       370        380        390 
RLAEFGRKAW EYGIRNAAEI MARHVLQLAE PSK

« Hide

References

[1]"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed: 12381787] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCC 2705.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE014295 Genomic DNA. Translation: AAN25123.1.
RefSeqNP_696487.1. NC_004307.2.

3D structure databases

ProteinModelPortalQ8CY50.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1023161.
GenomeReviewsGene locus BL1323 in contig AE014295_GR.
KEGGblo:BL1323.
PATRIC21117383. VBIBifLon107831_0174.

Phylogenomic databases

HOGENOMHBG617076.
OMAVPLPHGN.
PhylomeDBQ8CY50.
ProtClustDBPRK00726.

Enzyme and pathway databases

BioCycBLON206672:BL1323-MONOMER.

Family and domain databases

HAMAPMF_00033. MurG.
[Tree]
InterProIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
KOK02563.
PANTHERPTHR21015:SF22. PTHR21015:SF22. 1 hit.
PfamPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMURG_BIFLO
AccessionPrimary (citable) accession number: Q8CY50
Entry history
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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