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Q8CY39

- MURG_BRUSU

UniProt

Q8CY39 - MURG_BRUSU

Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

    Catalytic activityi

    UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity Source: UniProtKB-EC
    3. undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. lipid glycosylation Source: UniProtKB-HAMAP
    4. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    5. regulation of cell shape Source: UniProtKB-KW
    6. UDP-N-acetylgalactosamine biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
    Alternative name(s):
    Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
    Gene namesi
    Name:murGUniRule annotation
    Ordered Locus Names:BR1431, BS1330_I1425
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    Subcellular locationi

    Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 379379UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferasePRO_0000109152Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi204722.BR1431.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CY39.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0707.
    HOGENOMiHOG000218321.
    KOiK02563.
    OMAiPFIKDMA.
    OrthoDBiEOG61VZFD.

    Family and domain databases

    HAMAPiMF_00033. MurG.
    InterProiIPR006009. GlcNAc_MurG.
    IPR004276. Glyco_trans_28.
    IPR007235. Glyco_trans_28_C.
    [Graphical view]
    PfamiPF04101. Glyco_tran_28_C. 1 hit.
    PF03033. Glyco_transf_28. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01133. murG. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8CY39-1 [UniParc]FASTAAdd to Basket

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    MDNLANQGVI VLAAGGTGGH LFPAEALAHE LRARGWDVHL ATDARAQRFV    50
    GAFAQDHVHV IRSATIAGRN PVALLKTFWS LWQGNLDSRK LFRRLKPKLV 100
    VGFGGYPTLP PLYAASNMGI PTLIHEQNAV MGRANKGLAG RVKAIAGGFL 150
    PENSGAYAAK TVITGNPVRP PVLVAAATPY TPAGKDDRFR LLVFGGSQGA 200
    QFFSQAIPAA VALLPEHERA RLLITQQARK EDEASARQAY EKLGVPADVA 250
    PFFNDMPARM ADAHFVIARS GASTVSEITV IGRPAMLVPF PHALDHDQAA 300
    NAAALAAAGG AEVVRQADLS PQRLAEMLQS AMNEPERLEQ QAKAAKSVGK 350
    PDAARLLADL AEAIVSGKTV QEFKEGNRP 379
    Length:379
    Mass (Da):40,236
    Last modified:March 1, 2003 - v1
    Checksum:i705EE98D96F30177
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30344.1.
    CP002997 Genomic DNA. Translation: AEM18760.1.
    RefSeqiNP_698429.1. NC_004310.3.
    YP_005616252.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN30344; AAN30344; BR1431.
    AEM18760; AEM18760; BS1330_I1425.
    GeneIDi1167113.
    12138464.
    KEGGibms:BR1431.
    bsi:BS1330_I1425.
    PATRICi17791221. VBIBruSui107850_1457.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30344.1 .
    CP002997 Genomic DNA. Translation: AEM18760.1 .
    RefSeqi NP_698429.1. NC_004310.3.
    YP_005616252.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8CY39.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR1431.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN30344 ; AAN30344 ; BR1431 .
    AEM18760 ; AEM18760 ; BS1330_I1425 .
    GeneIDi 1167113.
    12138464.
    KEGGi bms:BR1431.
    bsi:BS1330_I1425.
    PATRICi 17791221. VBIBruSui107850_1457.

    Phylogenomic databases

    eggNOGi COG0707.
    HOGENOMi HOG000218321.
    KOi K02563.
    OMAi PFIKDMA.
    OrthoDBi EOG61VZFD.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .

    Family and domain databases

    HAMAPi MF_00033. MurG.
    InterProi IPR006009. GlcNAc_MurG.
    IPR004276. Glyco_trans_28.
    IPR007235. Glyco_trans_28_C.
    [Graphical view ]
    Pfami PF04101. Glyco_tran_28_C. 1 hit.
    PF03033. Glyco_transf_28. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01133. murG. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiMURG_BRUSU
    AccessioniPrimary (citable) accession number: Q8CY39
    Secondary accession number(s): G0KBJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 7, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3