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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei602 – 6021For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:BRA0582, BS1330_II0577
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000007104 Componenti: Chromosome II UP000000824 Componenti: Chromosome II

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 607606Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135310Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi204722.BRA0582.

Structurei

3D structure databases

ProteinModelPortaliQ8CY30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 217216Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini283 – 422140SIS 1UniRule annotationAdd
BLAST
Domaini455 – 597143SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiSEFRYAP.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CY30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIIGIIGN DEVAPRLVDA LKRLEYRGYD SAGIATLQNG RLDRRRAEGK
60 70 80 90 100
LVNLEKRLAG EPLPGVIGIG HTRWATHGRP VERNAHPHIT TRLAVVHNGI
110 120 130 140 150
IENFAELRAM LEAEGRKFET ETDTEAVAHL VTRELEKGKS PVEAVRDCLP
160 170 180 190 200
HLKGAFALAF LFEGDEELLI GARQGPPLAV GYGEGEMFLG SDAIALAPFT
210 220 230 240 250
DTISYLEDGD WAVLTRNGVS IYDENNKPVE RPVQKSQNTN MLVSKGNHRH
260 270 280 290 300
FMQKEMFEQP EVISHTLANY LDFTTGKVRK EAIGIDFSKV DRLTITACGT
310 320 330 340 350
AYYAATVAKY WFEQIARLPV DSDIASEFRY REMPLSKDSL AMFVSQSGET
360 370 380 390 400
ADTLASLRYC KAQGLKIASV VNVTGSTIAR ESDAVFPTLA GPEIGVASTK
410 420 430 440 450
AFTCQLSAMA SLAIAAARAR GAIDEVREQE LVHQLSEAPR FINQVLKLED
460 470 480 490 500
QIAAVCHDLS KVNHVLYLGR GTSFPLAMEG ALKLKEISYI HAEGYAAGEL
510 520 530 540 550
KHGPIALIDE TMPVIVIAPS DRLYEKTVSN MQEVAARGGR IILITDKKGA
560 570 580 590 600
ESASIDTMAT IVLPEVPEFI SPLVYALPIQ MLAYHTAVLM GTDVDQPRNL

AKSVTVE
Length:607
Mass (Da):66,307
Last modified:January 23, 2007 - v3
Checksum:iA1C65B027B5BBCED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014292 Genomic DNA. Translation: AAN33771.1.
CP002998 Genomic DNA. Translation: AEM20048.1.
RefSeqiNP_699766.1. NC_004311.2.
WP_004689005.1. NZ_KN046805.1.
YP_005614274.1. NC_017250.1.

Genome annotation databases

EnsemblBacteriaiAAN33771; AAN33771; BRA0582.
AEM20048; AEM20048; BS1330_II0577.
KEGGibms:BRA0582.
bsi:BS1330_II0577.
PATRICi17793967. VBIBruSui107850_2798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014292 Genomic DNA. Translation: AAN33771.1.
CP002998 Genomic DNA. Translation: AEM20048.1.
RefSeqiNP_699766.1. NC_004311.2.
WP_004689005.1. NZ_KN046805.1.
YP_005614274.1. NC_017250.1.

3D structure databases

ProteinModelPortaliQ8CY30.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi204722.BRA0582.

Protein family/group databases

MEROPSiC44.971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN33771; AAN33771; BRA0582.
AEM20048; AEM20048; BS1330_II0577.
KEGGibms:BRA0582.
bsi:BS1330_II0577.
PATRICi17793967. VBIBruSui107850_2798.

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiSEFRYAP.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiGLMS_BRUSU
AccessioniPrimary (citable) accession number: Q8CY30
Secondary accession number(s): G0KCW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: January 23, 2007
Last modified: May 27, 2015
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.