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Q8CXK7 (PUR9_OCEIH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:OB0749
OrganismOceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831) [Complete proteome] [HAMAP]
Taxonomic identifier221109 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeOceanobacillus

Protein attributes

Sequence length510 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 510510Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_0000192110

Sequences

Sequence LengthMass (Da)Tools
Q8CXK7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: CF97634E7DCC65A5

FASTA51055,747
        10         20         30         40         50         60 
MSKRALISVS DKTNIIEFAK GLKESGFEIL STGGTLRSIA EAGIDVTPVD EVTGFPEMLD 

        70         80         90        100        110        120 
GRVKTLHPMI HGGLLGKRSN HEHLSQMEEH GIRSIDLVAV NLYPFKETVQ KPDVSHQDII 

       130        140        150        160        170        180 
ENIDIGGPSM LRSAAKNFED VLVVTGPTDY NRVLAAITSE TDTYEFRQQL AAKVFRHTAS 

       190        200        210        220        230        240 
YDAMIANYFL SQTEEQYPES YTVTYEKVQD LRYGENPHQQ AAFYKEPIQS RPTLATAKQL 

       250        260        270        280        290        300 
HGKELSYNNI QDTNAAIEIV KEFAEPAAVA VKHMNPCGIG IGESISTAFE RAYQADPTSI 

       310        320        330        340        350        360 
FGGIVACNRP VDAATAEQLS QIFLEIVVAP SFESQALEIL TQKKNIRLLE LDVTSDNKQS 

       370        380        390        400        410        420 
NRLTTVDGGA LIQAYDAKEV SEADLEVVTN KQPTEQEIND MLFAWKAVKH VKSNAIVLAK 

       430        440        450        460        470        480 
DSQTIGVGAG QMNRIGAAEI AIKQAGDKSE GAVLASDAFF PMPDTVEAAA KAGIKAIIQP 

       490        500        510 
GGSKRDQDSV DVCNQFGIAM VYTKVRHFKH 

« Hide

References

[1]"Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments."
Takami H., Takaki Y., Uchiyama I.
Nucleic Acids Res. 30:3927-3935(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000028 Genomic DNA. Translation: BAC12705.1.
RefSeqNP_691670.1. NC_004193.1.

3D structure databases

ProteinModelPortalQ8CXK7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING221109.OB0749.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC12705; BAC12705; BAC12705.
GeneID1016275.
KEGGoih:OB0749.
PATRIC22792459. VBIOceIhe82024_0765.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMARAFKTDP.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

BioCycOIHE221109:GI2A-814-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_OCEIH
AccessionPrimary (citable) accession number: Q8CXK7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways