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Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.UniRule annotation
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation, Transcription termination

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciOIHE221109:GI2A-1565-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PyrRUniRule annotation
Including the following 2 domains:
Pyrimidine operon regulatory proteinUniRule annotation
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Short name:
UPRTaseUniRule annotation
Gene namesi
Name:pyrRUniRule annotation
Ordered Locus Names:OB1487
OrganismiOceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
Taxonomic identifieri221109 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeOceanobacillus
Proteomesi
  • UP000000822 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Bifunctional protein PyrRPRO_1000073134Add
BLAST

Interactioni

Subunit structurei

Homodimer and homohexamer; in equilibrium.UniRule annotation

Protein-protein interaction databases

STRINGi221109.OB1487.

Structurei

3D structure databases

ProteinModelPortaliQ8CXH9.
SMRiQ8CXH9. Positions 4-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi101 – 11313PRPP-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UK1. Bacteria.
COG2065. LUCA.
HOGENOMiHOG000245770.
OMAiHLPIQPN.
OrthoDBiEOG61VZD8.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01219. PyrR.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CXH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKTEILDA ASIQRALTRM SHEILEKNKG GENLVLIGIK TRGVPLAKRI
60 70 80 90 100
QQKIKQIESI EVPLGELDIT MYRDDLDKVS EQEDPKINSV SIGMDITDKH
110 120 130 140 150
VILIDDVLFT GRTVRAAMDA VMDVGRPSTI QLGSLVDRGH RELPIRADYV
160 170 180
GKNIPTSDRE IVVVQLSEQD QEDRVSLYEK
Length:180
Mass (Da):20,245
Last modified:March 1, 2003 - v1
Checksum:i5029B5B2F3F85CB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000028 Genomic DNA. Translation: BAC13443.1.
RefSeqiWP_011065888.1. NC_004193.1.

Genome annotation databases

EnsemblBacteriaiBAC13443; BAC13443; BAC13443.
PATRICi22793994. VBIOceIhe82024_1513.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000028 Genomic DNA. Translation: BAC13443.1.
RefSeqiWP_011065888.1. NC_004193.1.

3D structure databases

ProteinModelPortaliQ8CXH9.
SMRiQ8CXH9. Positions 4-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi221109.OB1487.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC13443; BAC13443; BAC13443.
PATRICi22793994. VBIOceIhe82024_1513.

Phylogenomic databases

eggNOGiENOG4108UK1. Bacteria.
COG2065. LUCA.
HOGENOMiHOG000245770.
OMAiHLPIQPN.
OrthoDBiEOG61VZD8.

Enzyme and pathway databases

BioCyciOIHE221109:GI2A-1565-MONOMER.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01219. PyrR.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments."
    Takami H., Takaki Y., Uchiyama I.
    Nucleic Acids Res. 30:3927-3935(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

Entry informationi

Entry nameiPYRR_OCEIH
AccessioniPrimary (citable) accession number: Q8CXH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: January 20, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.