Reviewed, UniProtKB/Swiss-Prot Q8CXE0 (GCSPA_OCEIH)

Names and origin

Protein names

Recommended name:
    Probable glycine dehydrogenase [decarboxylating] subunit 1
    EC=1.4.4.2
Alternative name(s):
    Glycine decarboxylase subunit 1
    Glycine cleavage system P-protein subunit 1

Gene names

Name:	gcvPA
Ordered Locus Names:	OB1903

Organism

Oceanobacillus iheyensis [Complete proteome] [HAMAP]

Taxonomic identifier

182710 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Oceanobacillus

Protein attributes

Sequence length	449 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.
Sequence similarities	Belongs to the gcvP family. N-terminal subunit subfamily.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 449	449	Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712		PRO_0000166969

Sequences

	Sequence		Length	Mass (Da)
	Q8CXE0-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 75554C029B2B1750	FASTA	449	49,746
	10 20 30 40 50 60 MEFRYLPMTN QDKQEMLDAI GIKSTEELFS DIPEHVRFKG EMNLKAPISE YELTKELTEL 70 80 90 100 110 120 ASRNIHTKEY TSFLGAGVYD HYIPSVVDHV ISRSEFYTAY TPYQPEISQG ELQAIFEFQT 130 140 150 160 170 180 MISELTGLPV ANSSMYDGGT ALAEAVNLSA AHTKRKKVLV SKAVHPEYRA VIDSYTRGQS 190 200 210 220 230 240 IDIVEIDTVN GVTDLAQLDQ AIDETIAGVV VQYPNFFGQL EPMKKIEQLL ENHQKTMLIV 250 260 270 280 290 300 SSNPLALGYL TPPGEFGADI VTGDTQVFGI PAQFGGPHCG YFATSKKLMR KVPGRLVGET 310 320 330 340 350 360 VDEEGTRGYV LTLQAREQHI RRDKATSNIC SNQALNALAS SVAMSSIGKH GLRKLASVNM 370 380 390 400 410 420 QKARYARKKL LEAGVELAFD GSFFNEFVIK VPGSVSKINK QLLDKGIIAG YDLAKDDKSL 430 440 EGYMLIAVTE VRTKQEIDQF VKELGDIHV

References

[1]

"Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments." Takami H., Takaki Y., Uchiyama I. Nucleic Acids Res. 30:3927-3935(2002) [PubMed: 12235376] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000028 Genomic DNA. Translation: BAC13859.1.
RefSeq	NP_692824.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1018395.
GenomeReviews	Gene locus OB1903 in contig BA000028_GR.
KEGG	oih:OB1903.
NMPDR	fig|221109.1.peg.1903.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8CXE0.
OMA	Q8CXE0. VANASMY.
Enzyme and pathway databases
BioCyc	OIHE221109:OB1903-MON.
BRENDA	1.4.4.2. 278212.
Family and domain databases
HAMAP	MF_00712. [Tree]
InterPro	IPR003437. GDC-P. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCSPA_OCEIH

Accession

Primary (citable) accession number: Q8CXE0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	March 1, 2003
Last modified:	June 16, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)