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Q8CXE0

- GCSPA_OCEIH

UniProt

Q8CXE0 - GCSPA_OCEIH

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciOIHE221109:GI2A-1979-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:OB1903
    OrganismiOceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
    Taxonomic identifieri221109 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeOceanobacillus
    ProteomesiUP000000822: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 449449Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_0000166969Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi221109.OB1903.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CXE0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0403.
    HOGENOMiHOG000132025.
    KOiK00282.
    OMAiRLVGQTE.
    OrthoDBiEOG6XWV3B.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8CXE0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFRYLPMTN QDKQEMLDAI GIKSTEELFS DIPEHVRFKG EMNLKAPISE    50
    YELTKELTEL ASRNIHTKEY TSFLGAGVYD HYIPSVVDHV ISRSEFYTAY 100
    TPYQPEISQG ELQAIFEFQT MISELTGLPV ANSSMYDGGT ALAEAVNLSA 150
    AHTKRKKVLV SKAVHPEYRA VIDSYTRGQS IDIVEIDTVN GVTDLAQLDQ 200
    AIDETIAGVV VQYPNFFGQL EPMKKIEQLL ENHQKTMLIV SSNPLALGYL 250
    TPPGEFGADI VTGDTQVFGI PAQFGGPHCG YFATSKKLMR KVPGRLVGET 300
    VDEEGTRGYV LTLQAREQHI RRDKATSNIC SNQALNALAS SVAMSSIGKH 350
    GLRKLASVNM QKARYARKKL LEAGVELAFD GSFFNEFVIK VPGSVSKINK 400
    QLLDKGIIAG YDLAKDDKSL EGYMLIAVTE VRTKQEIDQF VKELGDIHV 449
    Length:449
    Mass (Da):49,746
    Last modified:March 1, 2003 - v1
    Checksum:i75554C029B2B1750
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000028 Genomic DNA. Translation: BAC13859.1.
    RefSeqiNP_692824.1. NC_004193.1.

    Genome annotation databases

    EnsemblBacteriaiBAC13859; BAC13859; BAC13859.
    GeneIDi1018395.
    KEGGioih:OB1903.
    PATRICi22794832. VBIOceIhe82024_1932.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000028 Genomic DNA. Translation: BAC13859.1 .
    RefSeqi NP_692824.1. NC_004193.1.

    3D structure databases

    ProteinModelPortali Q8CXE0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 221109.OB1903.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC13859 ; BAC13859 ; BAC13859 .
    GeneIDi 1018395.
    KEGGi oih:OB1903.
    PATRICi 22794832. VBIOceIhe82024_1932.

    Phylogenomic databases

    eggNOGi COG0403.
    HOGENOMi HOG000132025.
    KOi K00282.
    OMAi RLVGQTE.
    OrthoDBi EOG6XWV3B.

    Enzyme and pathway databases

    BioCyci OIHE221109:GI2A-1979-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments."
      Takami H., Takaki Y., Uchiyama I.
      Nucleic Acids Res. 30:3927-3935(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

    Entry informationi

    Entry nameiGCSPA_OCEIH
    AccessioniPrimary (citable) accession number: Q8CXE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3