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Q8CXE0

- GCSPA_OCEIH

UniProt

Q8CXE0 - GCSPA_OCEIH

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciOIHE221109:GI2A-1979-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:OB1903
OrganismiOceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
Taxonomic identifieri221109 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeOceanobacillus
ProteomesiUP000000822: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_0000166969Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi221109.OB1903.

Structurei

3D structure databases

ProteinModelPortaliQ8CXE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CXE0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFRYLPMTN QDKQEMLDAI GIKSTEELFS DIPEHVRFKG EMNLKAPISE
60 70 80 90 100
YELTKELTEL ASRNIHTKEY TSFLGAGVYD HYIPSVVDHV ISRSEFYTAY
110 120 130 140 150
TPYQPEISQG ELQAIFEFQT MISELTGLPV ANSSMYDGGT ALAEAVNLSA
160 170 180 190 200
AHTKRKKVLV SKAVHPEYRA VIDSYTRGQS IDIVEIDTVN GVTDLAQLDQ
210 220 230 240 250
AIDETIAGVV VQYPNFFGQL EPMKKIEQLL ENHQKTMLIV SSNPLALGYL
260 270 280 290 300
TPPGEFGADI VTGDTQVFGI PAQFGGPHCG YFATSKKLMR KVPGRLVGET
310 320 330 340 350
VDEEGTRGYV LTLQAREQHI RRDKATSNIC SNQALNALAS SVAMSSIGKH
360 370 380 390 400
GLRKLASVNM QKARYARKKL LEAGVELAFD GSFFNEFVIK VPGSVSKINK
410 420 430 440
QLLDKGIIAG YDLAKDDKSL EGYMLIAVTE VRTKQEIDQF VKELGDIHV
Length:449
Mass (Da):49,746
Last modified:March 1, 2003 - v1
Checksum:i75554C029B2B1750
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000028 Genomic DNA. Translation: BAC13859.1.
RefSeqiNP_692824.1. NC_004193.1.

Genome annotation databases

EnsemblBacteriaiBAC13859; BAC13859; BAC13859.
GeneIDi1018395.
KEGGioih:OB1903.
PATRICi22794832. VBIOceIhe82024_1932.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000028 Genomic DNA. Translation: BAC13859.1 .
RefSeqi NP_692824.1. NC_004193.1.

3D structure databases

ProteinModelPortali Q8CXE0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 221109.OB1903.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC13859 ; BAC13859 ; BAC13859 .
GeneIDi 1018395.
KEGGi oih:OB1903.
PATRICi 22794832. VBIOceIhe82024_1932.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci OIHE221109:GI2A-1979-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments."
    Takami H., Takaki Y., Uchiyama I.
    Nucleic Acids Res. 30:3927-3935(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

Entry informationi

Entry nameiGCSPA_OCEIH
AccessioniPrimary (citable) accession number: Q8CXE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3