ID   GPR_OCEIH               Reviewed;         367 AA.
AC   Q8CXC9;
DT   25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   16-JUN-2009, entry version 39.
DE   RecName: Full=Germination protease;
DE            EC=3.4.24.78;
DE   AltName: Full=Spore protease;
DE   AltName: Full=GPR endopeptidase;
DE   AltName: Full=Germination proteinase;
DE   Flags: Precursor;
GN   Name=gpr; OrderedLocusNames=OB1975;
OS   Oceanobacillus iheyensis.
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Oceanobacillus.
OX   NCBI_TaxID=182710;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14371 / JCM 11309 / KCTC 3954 / HTE831;
RX   MEDLINE=22220767; PubMed=12235376; DOI=10.1093/nar/gkf526;
RA   Takami H., Takaki Y., Uchiyama I.;
RT   "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya
RT   Ridge and its unexpected adaptive capabilities to extreme
RT   environments.";
RL   Nucleic Acids Res. 30:3927-3935(2002).
CC   -!- FUNCTION: Initiates the rapid degradation of small, acid-soluble
CC       proteins during spore germination (By similarity).
CC   -!- CATALYTIC ACTIVITY: Endopeptidase action with P4 Glu or Asp, P1
CC       preferably Glu > Asp, P1' hydrophobic and P2' Ala.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- PTM: Autoproteolytically processed. The inactive tetrameric
CC       zymogen termed p46 autoprocesses to a smaller form termed p41,
CC       which is active only during spore germination (By similarity).
CC   -!- SIMILARITY: Belongs to the peptidase A25 family.
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DR   EMBL; BA000028; BAC13931.1; -; Genomic_DNA.
DR   RefSeq; NP_692896.1; -.
DR   HSSP; P22321; 1C8B.
DR   MEROPS; A25.001; -.
DR   GeneID; 1018452; -.
DR   GenomeReviews; BA000028_GR; OB1975.
DR   KEGG; oih:OB1975; -.
DR   NMPDR; fig|221109.1.peg.1975; -.
DR   HOGENOM; Q8CXC9; -.
DR   OMA; Q8CXC9; LMVTRHL.
DR   BioCyc; OIHE221109:OB1975-MON; -.
DR   BRENDA; 3.4.24.78; 278212.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:HAMAP.
DR   GO; GO:0006508; P:proteolysis; IEA:HAMAP.
DR   GO; GO:0009847; P:spore germination; IEA:HAMAP.
DR   HAMAP; MF_00626; -; 1.
DR   InterPro; IPR005080; Peptidase_A25.
DR   Gene3D; G3DSA:3.40.50.10100; Peptidase_A25; 1.
DR   Pfam; PF03418; Peptidase_A25; 1.
DR   PIRSF; PIRSF019549; Peptidase_A25; 1.
DR   ProDom; PD041835; Peptidase_A25; 1.
DR   TIGRFAMs; TIGR01441; GPR; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Protease; Zymogen.
FT   PROPEP        1     13       By similarity.
FT                                /FTId=PRO_0000026878.
FT   CHAIN        14    367       Germination protease.
FT                                /FTId=PRO_0000026879.
SQ   SEQUENCE   367 AA;  40467 MW;  3F4985F73F2CE5C7 CRC64;
     MEEQQIPFQV RTDLAIEAKD MYTESKPEET NDKEIKGVTF KERSVKDIKV SYVDIDEEGE
     KLLGKKPGSY VTIYADGVKK QDTDRQGQAA QVLAKELEDL MRKNNVTKES TCLVVGLGNW
     NVTPDALGPM TVEKVLVTSH LFRLQYETVA QGYRDVAAVT PGVMGVTGIE TSDIIFGIVE
     KYKPDLVIAV DALASRSINR VNETIQLSDT GIHPGSGVGN KRKEISKKTL GIPVIAIGVP
     TVVDAVTITS DTIDYVLKHF GREWKEKDDP SKSLTPAGMS FGNRKLTDED LPNMEKRKTV
     LGIVGELSDE EKRKLITEVL TPLGHNLMVT PKEVDGFMID MAEVLANGIN AALHEKVDVD
     NFANYSR
//