Q8CXC9 (GPR_OCEIH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Germination protease
EC=3.4.24.78

Alternative name(s):
GPR endopeptidase
Germination proteinase
Spore protease

Gene names

Name:	gpr
Ordered Locus Names:	OB1975

Organism

Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831) [Complete proteome] [HAMAP]

Taxonomic identifier

221109 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Oceanobacillus

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Initiates the rapid degradation of small, acid-soluble proteins during spore germination By similarity. HAMAP MF_00626
Catalytic activity	Endopeptidase action with P4 Glu or Asp, P1 preferably Glu > Asp, P1' hydrophobic and P2' Ala. HAMAP MF_00626
Subunit structure	Homotetramer By similarity. HAMAP MF_00626
Post-translational modification	Autoproteolytically processed. The inactive tetrameric zymogen termed p46 autoprocesses to a smaller form termed p41, which is active only during spore germination By similarity. HAMAP MF_00626
Sequence similarities	Belongs to the peptidase A25 family.

Ontologies

Keywords
Molecular function	Hydrolase Protease
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW spore germination Inferred from electronic annotation. Source: InterPro
Molecular function	peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 13	13	By similarity		PRO_0000026878
	Chain	14 – 367	354	Germination protease HAMAP MF_00626		PRO_0000026879

Sequences

	Sequence		Length	Mass (Da)
	Q8CXC9 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 3F4985F73F2CE5C7	FASTA	367	40,467
	10 20 30 40 50 60 MEEQQIPFQV RTDLAIEAKD MYTESKPEET NDKEIKGVTF KERSVKDIKV SYVDIDEEGE 70 80 90 100 110 120 KLLGKKPGSY VTIYADGVKK QDTDRQGQAA QVLAKELEDL MRKNNVTKES TCLVVGLGNW 130 140 150 160 170 180 NVTPDALGPM TVEKVLVTSH LFRLQYETVA QGYRDVAAVT PGVMGVTGIE TSDIIFGIVE 190 200 210 220 230 240 KYKPDLVIAV DALASRSINR VNETIQLSDT GIHPGSGVGN KRKEISKKTL GIPVIAIGVP 250 260 270 280 290 300 TVVDAVTITS DTIDYVLKHF GREWKEKDDP SKSLTPAGMS FGNRKLTDED LPNMEKRKTV 310 320 330 340 350 360 LGIVGELSDE EKRKLITEVL TPLGHNLMVT PKEVDGFMID MAEVLANGIN AALHEKVDVD NFANYSR

References

[1]	"Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments." Takami H., Takaki Y., Uchiyama I. Nucleic Acids Res. 30:3927-3935(2002) [PubMed: 12235376] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000028 Genomic DNA. Translation: BAC13931.1.
RefSeq	NP_692896.1. NC_004193.1.
3D structure databases
ProteinModelPortal	Q8CXC9.
SMR	Q8CXC9. Positions 6-366.
ModBase	Search...
Protein family/group databases
MEROPS	A25.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1018452.
GenomeReviews	Gene locus OB1975 in contig BA000028_GR.
KEGG	oih:OB1975.
NMPDR	fig|221109.1.peg.1975.
PATRIC	22794988. VBIOceIhe82024_2004.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG304865.
OMA	VNTTIQI.
ProtClustDB	PRK02858.
Enzyme and pathway databases
BioCyc	OIHE221109:OB1975-MONOMER.
Family and domain databases
HAMAP	MF_00626. Germination_prot. [Tree]
InterPro	IPR023430. Pept_HybD-like_dom. IPR005080. Peptidase_A25. [Graphical view]
Gene3D	G3DSA:3.40.50.1450. Peptidase_A31. 2 hits.
KO	K06012.
Pfam	PF03418. Peptidase_A25. 1 hit. [Graphical view]
PIRSF	PIRSF019549. Peptidase_A25. 1 hit.
ProDom	PD041835. Peptidase_A25. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF53163. SSF53163. 1 hit.
TIGRFAMs	TIGR01441. GPR. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GPR_OCEIH

Accession

Primary (citable) accession number: Q8CXC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 25, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program