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Q8CX33

- GLMS_SHEON

UniProt

Q8CX33 - GLMS_SHEON

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, SO_4741
Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei604 – 6041For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:SO_4741
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000008186: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 609608Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135376Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi211586.SO_4741.

Structurei

3D structure databases

ProteinModelPortaliQ8CX33.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 218217Glutamine amidotransferase type-2
Add
BLAST
Domaini286 – 426141SIS 1
Add
BLAST
Domaini458 – 599142SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiFYTHAGP.
OrthoDBiEOG6KT2Q1.
PhylomeDBiQ8CX33.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CX33-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIVGAVAQ RDVAEILVEG LRRLEYRGYD SAGVAVIHNG ELNRTRRVGK    50
VQELSAALET DPLAGGTGIA HTRWATHGEP SERNAHPHLS EGDIAVVHNG 100
IIENHHKLRE MLKEHGYHFS SDTDTEVICH LVHHQLKTND SLLAAVQATV 150
KQLEGAYGTV VIDRRDSERM VVARSGSPLV IGFGLGENFV ASDQLALLPV 200
TRSFAFLEEG DVAEVTRRTV SIFDVHGNKV EREVKESEIT HDAGDKGEYR 250
HYMLKEIYEQ PLALTRTIEG RIANKQVLDT AFGDNAAEFL KDIKHVQIIA 300
CGTSYHAGMA ARYWLEDWAG VSCNVEIASE FRYRKSHLFP NSLLVTISQS 350
GETADTLAAM RLAKEMGYKA TLTICNAPGS SLVRESDMAY MMKAGAEIGV 400
ASTKAFTVQL AGLLMLTAVI GRHNGMSEQM QAEITQSLQS MPAKVEQALG 450
LDDAIAELAE DFADKHHALF LGRGDQYPIA MEGALKLKEI SYIHAEAYAS 500
GELKHGPLAL IDADMPVIVV APNNELLEKL KSNVEEVRAR GGLMYVFADV 550
DAEFESDDTM KVIPVPHCDI FMAPLIYTIP LQLLSYHVAL IKGTDVDQPR 600
NLAKSVTVE 609
Length:609
Mass (Da):66,729
Last modified:January 23, 2007 - v3
Checksum:iB56C0CB7700FE814
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN57700.1.
RefSeqiNP_720257.1. NC_004347.2.
WP_011074325.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN57700; AAN57700; SO_4741.
GeneIDi1172318.
KEGGison:SO_4741.
PATRICi23529151. VBISheOne101494_4598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN57700.1 .
RefSeqi NP_720257.1. NC_004347.2.
WP_011074325.1. NC_004347.2.

3D structure databases

ProteinModelPortali Q8CX33.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 211586.SO_4741.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN57700 ; AAN57700 ; SO_4741 .
GeneIDi 1172318.
KEGGi son:SO_4741.
PATRICi 23529151. VBISheOne101494_4598.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258898.
KOi K00820.
OMAi FYTHAGP.
OrthoDBi EOG6KT2Q1.
PhylomeDBi Q8CX33.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-1.

Entry informationi

Entry nameiGLMS_SHEON
AccessioniPrimary (citable) accession number: Q8CX33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi