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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei604 – 6041For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:SO_4741
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000008186 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 609608Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135376Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi211586.SO_4741.

Structurei

3D structure databases

ProteinModelPortaliQ8CX33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 218217Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini286 – 426141SIS 1UniRule annotationAdd
BLAST
Domaini458 – 599142SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiSEFRYAP.
OrthoDBiEOG6KT2Q1.
PhylomeDBiQ8CX33.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CX33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGAVAQ RDVAEILVEG LRRLEYRGYD SAGVAVIHNG ELNRTRRVGK
60 70 80 90 100
VQELSAALET DPLAGGTGIA HTRWATHGEP SERNAHPHLS EGDIAVVHNG
110 120 130 140 150
IIENHHKLRE MLKEHGYHFS SDTDTEVICH LVHHQLKTND SLLAAVQATV
160 170 180 190 200
KQLEGAYGTV VIDRRDSERM VVARSGSPLV IGFGLGENFV ASDQLALLPV
210 220 230 240 250
TRSFAFLEEG DVAEVTRRTV SIFDVHGNKV EREVKESEIT HDAGDKGEYR
260 270 280 290 300
HYMLKEIYEQ PLALTRTIEG RIANKQVLDT AFGDNAAEFL KDIKHVQIIA
310 320 330 340 350
CGTSYHAGMA ARYWLEDWAG VSCNVEIASE FRYRKSHLFP NSLLVTISQS
360 370 380 390 400
GETADTLAAM RLAKEMGYKA TLTICNAPGS SLVRESDMAY MMKAGAEIGV
410 420 430 440 450
ASTKAFTVQL AGLLMLTAVI GRHNGMSEQM QAEITQSLQS MPAKVEQALG
460 470 480 490 500
LDDAIAELAE DFADKHHALF LGRGDQYPIA MEGALKLKEI SYIHAEAYAS
510 520 530 540 550
GELKHGPLAL IDADMPVIVV APNNELLEKL KSNVEEVRAR GGLMYVFADV
560 570 580 590 600
DAEFESDDTM KVIPVPHCDI FMAPLIYTIP LQLLSYHVAL IKGTDVDQPR

NLAKSVTVE
Length:609
Mass (Da):66,729
Last modified:January 23, 2007 - v3
Checksum:iB56C0CB7700FE814
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA. Translation: AAN57700.1.
RefSeqiNP_720257.1. NC_004347.2.
WP_011074325.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN57700; AAN57700; SO_4741.
GeneIDi1172318.
KEGGison:SO_4741.
PATRICi23529151. VBISheOne101494_4598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA. Translation: AAN57700.1.
RefSeqiNP_720257.1. NC_004347.2.
WP_011074325.1. NC_004347.2.

3D structure databases

ProteinModelPortaliQ8CX33.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi211586.SO_4741.

Protein family/group databases

MEROPSiC44.971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN57700; AAN57700; SO_4741.
GeneIDi1172318.
KEGGison:SO_4741.
PATRICi23529151. VBISheOne101494_4598.

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiSEFRYAP.
OrthoDBiEOG6KT2Q1.
PhylomeDBiQ8CX33.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-1.

Entry informationi

Entry nameiGLMS_SHEON
AccessioniPrimary (citable) accession number: Q8CX33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: January 23, 2007
Last modified: May 27, 2015
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.