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Q8CWZ1 (UPPP_STRMU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:SMU_244
OrganismStreptococcus mutans serotype c (strain ATCC 700610 / UA159) [Complete proteome] [HAMAP]
Taxonomic identifier210007 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 281281Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151213

Regions

Transmembrane45 – 6521Helical; Potential
Transmembrane86 – 10621Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane148 – 16821Helical; Potential
Transmembrane196 – 21621Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane256 – 27621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q8CWZ1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 91F653A107674654

FASTA28131,363
        10         20         30         40         50         60 
MLFFEIIKAI IFGIVEGITE WLPISSTGHL ILVEEFIHFN NANAAFTNMF NVVIQLGAIL 

        70         80         90        100        110        120 
AVVVIYFDRL NPFKSGKTAR EVQITWQLWA KVILSALPAA VIGLIFDDWL DAHFQNFFSV 

       130        140        150        160        170        180 
ALMLILYGIA FIYVERRHQG VEPQVTHLVS LPYKTAFFIG LFQVLSLIPG TSRSGATILG 

       190        200        210        220        230        240 
GILLGTSRQV ATEFTFFLGI PIMFGASLVK VLKFIVSGTI LTGSQLFILL VAMLVAFAVS 

       250        260        270        280 
LYVIRFLTDY VKNHDFTFFG KYRIGLGILL LFYGLMKVLF G 

« Hide

References

[1]"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen."
Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.
Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700610 / UA159.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014133 Genomic DNA. Translation: AAN58014.1.
RefSeqNP_720708.1. NC_004350.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING210007.SMU.244.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN58014; AAN58014; SMU_244.
GeneID1027840.
KEGGsmu:SMU_244.
PATRIC19662751. VBIStrMut61772_0211.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycSMUT210007:GC7Z-260-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_STRMU
AccessionPrimary (citable) accession number: Q8CWZ1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families