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Q8CWZ1

- UPPP_STRMU

UniProt

Q8CWZ1 - UPPP_STRMU

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Protein

Undecaprenyl-diphosphatase

Gene
uppP, bacA, upk, SMU_244
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-260-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:SMU_244
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei45 – 6521Helical; Reviewed predictionAdd
BLAST
Transmembranei86 – 10621Helical; Reviewed predictionAdd
BLAST
Transmembranei114 – 13421Helical; Reviewed predictionAdd
BLAST
Transmembranei148 – 16821Helical; Reviewed predictionAdd
BLAST
Transmembranei196 – 21621Helical; Reviewed predictionAdd
BLAST
Transmembranei224 – 24421Helical; Reviewed predictionAdd
BLAST
Transmembranei256 – 27621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Undecaprenyl-diphosphataseUniRule annotationPRO_0000151213Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU.244.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
KOiK06153.
OMAiMEQINIG.
OrthoDBiEOG6QP13M.
PhylomeDBiQ8CWZ1.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CWZ1-1 [UniParc]FASTAAdd to Basket

« Hide

MLFFEIIKAI IFGIVEGITE WLPISSTGHL ILVEEFIHFN NANAAFTNMF    50
NVVIQLGAIL AVVVIYFDRL NPFKSGKTAR EVQITWQLWA KVILSALPAA 100
VIGLIFDDWL DAHFQNFFSV ALMLILYGIA FIYVERRHQG VEPQVTHLVS 150
LPYKTAFFIG LFQVLSLIPG TSRSGATILG GILLGTSRQV ATEFTFFLGI 200
PIMFGASLVK VLKFIVSGTI LTGSQLFILL VAMLVAFAVS LYVIRFLTDY 250
VKNHDFTFFG KYRIGLGILL LFYGLMKVLF G 281
Length:281
Mass (Da):31,363
Last modified:March 1, 2003 - v1
Checksum:i91F653A107674654
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014133 Genomic DNA. Translation: AAN58014.1.
RefSeqiNP_720708.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58014; AAN58014; SMU_244.
GeneIDi1027840.
KEGGismu:SMU_244.
PATRICi19662751. VBIStrMut61772_0211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014133 Genomic DNA. Translation: AAN58014.1 .
RefSeqi NP_720708.1. NC_004350.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 210007.SMU.244.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN58014 ; AAN58014 ; SMU_244 .
GeneIDi 1027840.
KEGGi smu:SMU_244.
PATRICi 19662751. VBIStrMut61772_0211.

Phylogenomic databases

eggNOGi COG1968.
KOi K06153.
OMAi MEQINIG.
OrthoDBi EOG6QP13M.
PhylomeDBi Q8CWZ1.

Enzyme and pathway databases

BioCyci SMUT210007:GC7Z-260-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.

Entry informationi

Entry nameiUPPP_STRMU
AccessioniPrimary (citable) accession number: Q8CWZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi