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Q8CWZ0

- ASSY_STRMU

UniProt

Q8CWZ0 - ASSY_STRMU

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Protein

Argininosuccinate synthase

Gene
argG, SMU_334
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851Citrulline By similarity
Binding sitei115 – 1151ATP; via amide nitrogen By similarity
Binding sitei117 – 1171Aspartate By similarity
Binding sitei121 – 1211Aspartate By similarity
Binding sitei121 – 1211Citrulline By similarity
Binding sitei122 – 1221Aspartate By similarity
Binding sitei125 – 1251Citrulline By similarity
Binding sitei173 – 1731Citrulline By similarity
Binding sitei258 – 2581Citrulline By similarity
Binding sitei270 – 2701Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 179ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-339-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:SMU_334
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Argininosuccinate synthaseUniRule annotationPRO_0000148647Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi210007.SMU.334.

Structurei

3D structure databases

ProteinModelPortaliQ8CWZ0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
KOiK01940.
OMAiYKALAPH.
OrthoDBiEOG6K9QCV.
PhylomeDBiQ8CWZ0.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CWZ0-1 [UniParc]FASTAAdd to Basket

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MSKEKVILAY SGGLDTSVAI TWLKKDYDVV AVCMDVGEGK DLEFIHDKAL    50
KVGAIESYVL DIKDEFAEEY VLPALQAHAY YEQKYPLVSA LSRPVISKKL 100
VEIAHQTGAT TIAHGCTGKG NDQVRFEVAI AALDPKLKVI APVREWKWSR 150
EEEINYAKEN GVPVPADLDN PYSVDQNLWG RANECGVLEN PWNQAPEEAF 200
GITNSVEEAP DKAEYVDITF KEGKPVALDG QEMKLADLIQ KLNVLAGKHG 250
VGRIDHVENR LVGIKSREIY ECPGAVTLLT AHKEIEDITL VREVSHFKPI 300
LENELSNLIY NALWFNPATQ AILAYITETQ KEVNGTAKVK LYKGSARVVA 350
RKSPHSLYDE NLATYTSADS FDQDAAVGFI KLWGLPTQVN SQVNNK 396
Length:396
Mass (Da):43,913
Last modified:March 1, 2003 - v1
Checksum:i44A7C6D56865137E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014133 Genomic DNA. Translation: AAN58093.1.
RefSeqiNP_720787.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58093; AAN58093; SMU_334.
GeneIDi1027892.
KEGGismu:SMU_334.
PATRICi19662907. VBIStrMut61772_0289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014133 Genomic DNA. Translation: AAN58093.1 .
RefSeqi NP_720787.1. NC_004350.2.

3D structure databases

ProteinModelPortali Q8CWZ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 210007.SMU.334.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN58093 ; AAN58093 ; SMU_334 .
GeneIDi 1027892.
KEGGi smu:SMU_334.
PATRICi 19662907. VBIStrMut61772_0289.

Phylogenomic databases

eggNOGi COG0137.
KOi K01940.
OMAi YKALAPH.
OrthoDBi EOG6K9QCV.
PhylomeDBi Q8CWZ0.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci SMUT210007:GC7Z-339-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.

Entry informationi

Entry nameiASSY_STRMU
AccessioniPrimary (citable) accession number: Q8CWZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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