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Q8CUU4

- PDXA_OCEIH

UniProt

Q8CUU4 - PDXA_OCEIH

Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

    Catalytic activityi

    4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

    Cofactori

    Binds 1 divalent metal cation per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei140 – 1401SubstrateUniRule annotation
    Binding sitei141 – 1411SubstrateUniRule annotation
    Metal bindingi170 – 1701Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi214 – 2141Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi270 – 2701Divalent metal cation; shared with dimeric partnerUniRule annotation
    Binding sitei278 – 2781SubstrateUniRule annotation
    Binding sitei287 – 2871SubstrateUniRule annotation
    Binding sitei296 – 2961SubstrateUniRule annotation

    GO - Molecular functioni

    1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
    2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, NADP

    Enzyme and pathway databases

    BioCyciOIHE221109:GI2A-1090-MONOMER.
    UniPathwayiUPA00244; UER00312.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
    Alternative name(s):
    4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
    Gene namesi
    Name:pdxAUniRule annotation
    Ordered Locus Names:OB1013
    OrganismiOceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
    Taxonomic identifieri221109 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeOceanobacillus
    ProteomesiUP000000822: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3323324-hydroxythreonine-4-phosphate dehydrogenasePRO_0000188813Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi221109.OB1013.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CUU4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PdxA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1995.
    HOGENOMiHOG000221591.
    KOiK00097.
    OMAiISIKLAM.
    OrthoDBiEOG6GN6ZC.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    HAMAPiMF_00536. PdxA.
    InterProiIPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view]
    PfamiPF04166. PdxA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00557. pdxA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8CUU4-1 [UniParc]FASTAAdd to Basket

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    MSKKPIIGIT MGDAAGVGPE IIIKSLRNRE LYEQAHPIVI GDTKMLERAA    50
    KILDVDVSFD KKTKDEELMD TEFGKITCID LDILPEDLAY GEVSPVSGNA 100
    AFEYLRMAIE LANEGKIQAI CTAPLNKEAL QKGGHMYPGH TEILAELTNT 150
    EEFSMMLSSP KLKVIHVTTH VGLIQAIQMI KPERVHKVIQ LAHETLSNSG 200
    IKNPKIGVCG INPHAGENGL FGNGEEEEKI IPAIQQAVKE GINVEGPLPA 250
    DTLFFRAQRG DFDIVVAMYH DQGHGPIKVL GLEAGVNITV GLPIIRTSVD 300
    HGTAFDIAGK GIVDERSMLE ALHQAIELAP TK 332
    Length:332
    Mass (Da):36,017
    Last modified:March 1, 2003 - v1
    Checksum:iED62C9CA66FCB51A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000028 Genomic DNA. Translation: BAC12969.1.
    RefSeqiNP_691934.1. NC_004193.1.
    WP_011065416.1. NC_004193.1.

    Genome annotation databases

    EnsemblBacteriaiBAC12969; BAC12969; BAC12969.
    GeneIDi1016871.
    KEGGioih:OB1013.
    PATRICi22793026. VBIOceIhe82024_1031.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000028 Genomic DNA. Translation: BAC12969.1 .
    RefSeqi NP_691934.1. NC_004193.1.
    WP_011065416.1. NC_004193.1.

    3D structure databases

    ProteinModelPortali Q8CUU4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 221109.OB1013.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC12969 ; BAC12969 ; BAC12969 .
    GeneIDi 1016871.
    KEGGi oih:OB1013.
    PATRICi 22793026. VBIOceIhe82024_1031.

    Phylogenomic databases

    eggNOGi COG1995.
    HOGENOMi HOG000221591.
    KOi K00097.
    OMAi ISIKLAM.
    OrthoDBi EOG6GN6ZC.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00312 .
    BioCyci OIHE221109:GI2A-1090-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    HAMAPi MF_00536. PdxA.
    InterProi IPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view ]
    Pfami PF04166. PdxA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00557. pdxA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments."
      Takami H., Takaki Y., Uchiyama I.
      Nucleic Acids Res. 30:3927-3935(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

    Entry informationi

    Entry nameiPDXA_OCEIH
    AccessioniPrimary (citable) accession number: Q8CUU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The active site is located at the dimer interface.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3