Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8CUU4

- PDXA_OCEIH

UniProt

Q8CUU4 - PDXA_OCEIH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

Cofactori

Binds 1 divalent metal cation per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei140 – 1401SubstrateUniRule annotation
Binding sitei141 – 1411SubstrateUniRule annotation
Metal bindingi170 – 1701Divalent metal cation; shared with dimeric partnerUniRule annotation
Metal bindingi214 – 2141Divalent metal cation; shared with dimeric partnerUniRule annotation
Metal bindingi270 – 2701Divalent metal cation; shared with dimeric partnerUniRule annotation
Binding sitei278 – 2781SubstrateUniRule annotation
Binding sitei287 – 2871SubstrateUniRule annotation
Binding sitei296 – 2961SubstrateUniRule annotation

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD binding Source: InterPro

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, NADP

Enzyme and pathway databases

BioCyciOIHE221109:GI2A-1090-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
Gene namesi
Name:pdxAUniRule annotation
Ordered Locus Names:OB1013
OrganismiOceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
Taxonomic identifieri221109 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeOceanobacillus
ProteomesiUP000000822: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3323324-hydroxythreonine-4-phosphate dehydrogenasePRO_0000188813Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi221109.OB1013.

Structurei

3D structure databases

ProteinModelPortaliQ8CUU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000221591.
KOiK00097.
OMAiISIKLAM.
OrthoDBiEOG6GN6ZC.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CUU4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKKPIIGIT MGDAAGVGPE IIIKSLRNRE LYEQAHPIVI GDTKMLERAA
60 70 80 90 100
KILDVDVSFD KKTKDEELMD TEFGKITCID LDILPEDLAY GEVSPVSGNA
110 120 130 140 150
AFEYLRMAIE LANEGKIQAI CTAPLNKEAL QKGGHMYPGH TEILAELTNT
160 170 180 190 200
EEFSMMLSSP KLKVIHVTTH VGLIQAIQMI KPERVHKVIQ LAHETLSNSG
210 220 230 240 250
IKNPKIGVCG INPHAGENGL FGNGEEEEKI IPAIQQAVKE GINVEGPLPA
260 270 280 290 300
DTLFFRAQRG DFDIVVAMYH DQGHGPIKVL GLEAGVNITV GLPIIRTSVD
310 320 330
HGTAFDIAGK GIVDERSMLE ALHQAIELAP TK
Length:332
Mass (Da):36,017
Last modified:March 1, 2003 - v1
Checksum:iED62C9CA66FCB51A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000028 Genomic DNA. Translation: BAC12969.1.
RefSeqiNP_691934.1. NC_004193.1.

Genome annotation databases

EnsemblBacteriaiBAC12969; BAC12969; BAC12969.
GeneIDi1016871.
KEGGioih:OB1013.
PATRICi22793026. VBIOceIhe82024_1031.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000028 Genomic DNA. Translation: BAC12969.1 .
RefSeqi NP_691934.1. NC_004193.1.

3D structure databases

ProteinModelPortali Q8CUU4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 221109.OB1013.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC12969 ; BAC12969 ; BAC12969 .
GeneIDi 1016871.
KEGGi oih:OB1013.
PATRICi 22793026. VBIOceIhe82024_1031.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000221591.
KOi K00097.
OMAi ISIKLAM.
OrthoDBi EOG6GN6ZC.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci OIHE221109:GI2A-1090-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments."
    Takami H., Takaki Y., Uchiyama I.
    Nucleic Acids Res. 30:3927-3935(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

Entry informationi

Entry nameiPDXA_OCEIH
AccessioniPrimary (citable) accession number: Q8CUU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3