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Q8CUL8

- ODO1_OCEIH

UniProt

Q8CUL8 - ODO1_OCEIH

Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotation

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

    Cofactori

    Thiamine pyrophosphate.UniRule annotation

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciOIHE221109:GI2A-1165-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
    Alternative name(s):
    Alpha-ketoglutarate dehydrogenaseUniRule annotation
    Gene namesi
    Name:odhAUniRule annotation
    Ordered Locus Names:OB1089
    OrganismiOceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
    Taxonomic identifieri221109 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeOceanobacillus
    ProteomesiUP000000822: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9539532-oxoglutarate dehydrogenase E1 componentPRO_0000162175Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi221109.OB1089.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CUL8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0567.
    HOGENOMiHOG000259588.
    KOiK00164.
    OMAiGHQNANL.
    OrthoDBiEOG6V1M1F.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    HAMAPiMF_01169. SucA_OdhA.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR023784. 2oxoglutarate_DH_E1_bac.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8CUL8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAENAESAER FWGQFHGQNT GYLEQQFELY KEDPELVESS IRTIFDTHGA    50
    PSWLSSTENV KSVSNASDFD VTKLTSAIRL VEAIRRYGHT DADIYPVGGY 100
    KGDRSKMLDL STYNLKEQDL EKIPASWIWE KQAPGVATAL DVVNQLKKYY 150
    TGTITFEYDH VNNDEERKWL FDLIEEGNAR LDPSDDERKK ILQRLADVEG 200
    FEKFLHKTFV GQKRFSIEGL ESMVPMIDHI VQYSNQDSIE HVMMGMAHRG 250
    RLSVLANVLG KPYDKIFSEF NYTKEKELMP SEGSRAINYG WTGDVKYHYG 300
    AEKEVEFGNK GQTRITLAHN PSHLEFVNPV VEGFTRAAQD DRSEKGYPKQ 350
    VTNKAVSVLI HGDAAFIGEG VVAETLNLSG LPGYSTGGTL HIIANNLLGY 400
    TTDREDGRST RYASDLAKGF EIPVIRVNAD DPISCISAIK IAYEYRQKFQ 450
    KDFLIDLVGY RRYGHNEMDE PRTTQPSLYQ QIDDHPSVAS LFGKGMEEKG 500
    ILQEGGFEEV KSAVEKKLTD IYKGMTESEI GEPEAKLMPQ VLTNGLDQFT 550
    TAIDLATLKS INEELLERPE GFKGFKKTER ILQRRKDALE EGNKADWGTG 600
    EALAFASILK EGTPIRLTGQ DTERGTFAHR HIVLHDVETG EKYSPLHGLS 650
    DVEASFDVRN SPLSEAGVLG FEYGYSVQSP DTLVIWEAQF GDFANAGQVI 700
    FDQFISSARA KWGEKSNMVL LLPHGYEGQG PEHSSARLER FLQMAAENNW 750
    IVANVTSSAQ LFHILRRQAA MRDRDEARPL VLMTPKSSLI RHPRMGATAE 800
    EFTDGGFLAL RDQPGFEANR EKVTRLVVGS GKMMIDIEEA MDDSDETYDW 850
    LQIKRVEQIY PFPKKALEEE IKQLPNLKEI VWVQEEPKNM GAWNFVDDYL 900
    RELLNEDQKL KVISRPDRSA PAGGIPTVHK TAQNKIIKQA LNQSEGGKSS 950
    AGN 953
    Length:953
    Mass (Da):107,266
    Last modified:March 1, 2003 - v1
    Checksum:i78AB32B7CFBE7A6E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000028 Genomic DNA. Translation: BAC13045.1.
    RefSeqiNP_692010.1. NC_004193.1.
    WP_011065490.1. NC_004193.1.

    Genome annotation databases

    EnsemblBacteriaiBAC13045; BAC13045; BAC13045.
    GeneIDi1017056.
    KEGGioih:OB1089.
    PATRICi22793182. VBIOceIhe82024_1108.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000028 Genomic DNA. Translation: BAC13045.1 .
    RefSeqi NP_692010.1. NC_004193.1.
    WP_011065490.1. NC_004193.1.

    3D structure databases

    ProteinModelPortali Q8CUL8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 221109.OB1089.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC13045 ; BAC13045 ; BAC13045 .
    GeneIDi 1017056.
    KEGGi oih:OB1089.
    PATRICi 22793182. VBIOceIhe82024_1108.

    Phylogenomic databases

    eggNOGi COG0567.
    HOGENOMi HOG000259588.
    KOi K00164.
    OMAi GHQNANL.
    OrthoDBi EOG6V1M1F.

    Enzyme and pathway databases

    BioCyci OIHE221109:GI2A-1165-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    HAMAPi MF_01169. SucA_OdhA.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR023784. 2oxoglutarate_DH_E1_bac.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments."
      Takami H., Takaki Y., Uchiyama I.
      Nucleic Acids Res. 30:3927-3935(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

    Entry informationi

    Entry nameiODO1_OCEIH
    AccessioniPrimary (citable) accession number: Q8CUL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3