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Q8CUL8

- ODO1_OCEIH

UniProt

Q8CUL8 - ODO1_OCEIH

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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

Thiamine pyrophosphate.UniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciOIHE221109:GI2A-1165-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenaseUniRule annotation
Gene namesi
Name:odhAUniRule annotation
Ordered Locus Names:OB1089
OrganismiOceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
Taxonomic identifieri221109 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeOceanobacillus
ProteomesiUP000000822: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9539532-oxoglutarate dehydrogenase E1 componentPRO_0000162175Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi221109.OB1089.

Structurei

3D structure databases

ProteinModelPortaliQ8CUL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiGHQNANL.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CUL8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAENAESAER FWGQFHGQNT GYLEQQFELY KEDPELVESS IRTIFDTHGA
60 70 80 90 100
PSWLSSTENV KSVSNASDFD VTKLTSAIRL VEAIRRYGHT DADIYPVGGY
110 120 130 140 150
KGDRSKMLDL STYNLKEQDL EKIPASWIWE KQAPGVATAL DVVNQLKKYY
160 170 180 190 200
TGTITFEYDH VNNDEERKWL FDLIEEGNAR LDPSDDERKK ILQRLADVEG
210 220 230 240 250
FEKFLHKTFV GQKRFSIEGL ESMVPMIDHI VQYSNQDSIE HVMMGMAHRG
260 270 280 290 300
RLSVLANVLG KPYDKIFSEF NYTKEKELMP SEGSRAINYG WTGDVKYHYG
310 320 330 340 350
AEKEVEFGNK GQTRITLAHN PSHLEFVNPV VEGFTRAAQD DRSEKGYPKQ
360 370 380 390 400
VTNKAVSVLI HGDAAFIGEG VVAETLNLSG LPGYSTGGTL HIIANNLLGY
410 420 430 440 450
TTDREDGRST RYASDLAKGF EIPVIRVNAD DPISCISAIK IAYEYRQKFQ
460 470 480 490 500
KDFLIDLVGY RRYGHNEMDE PRTTQPSLYQ QIDDHPSVAS LFGKGMEEKG
510 520 530 540 550
ILQEGGFEEV KSAVEKKLTD IYKGMTESEI GEPEAKLMPQ VLTNGLDQFT
560 570 580 590 600
TAIDLATLKS INEELLERPE GFKGFKKTER ILQRRKDALE EGNKADWGTG
610 620 630 640 650
EALAFASILK EGTPIRLTGQ DTERGTFAHR HIVLHDVETG EKYSPLHGLS
660 670 680 690 700
DVEASFDVRN SPLSEAGVLG FEYGYSVQSP DTLVIWEAQF GDFANAGQVI
710 720 730 740 750
FDQFISSARA KWGEKSNMVL LLPHGYEGQG PEHSSARLER FLQMAAENNW
760 770 780 790 800
IVANVTSSAQ LFHILRRQAA MRDRDEARPL VLMTPKSSLI RHPRMGATAE
810 820 830 840 850
EFTDGGFLAL RDQPGFEANR EKVTRLVVGS GKMMIDIEEA MDDSDETYDW
860 870 880 890 900
LQIKRVEQIY PFPKKALEEE IKQLPNLKEI VWVQEEPKNM GAWNFVDDYL
910 920 930 940 950
RELLNEDQKL KVISRPDRSA PAGGIPTVHK TAQNKIIKQA LNQSEGGKSS

AGN
Length:953
Mass (Da):107,266
Last modified:March 1, 2003 - v1
Checksum:i78AB32B7CFBE7A6E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000028 Genomic DNA. Translation: BAC13045.1.
RefSeqiNP_692010.1. NC_004193.1.
WP_011065490.1. NC_004193.1.

Genome annotation databases

EnsemblBacteriaiBAC13045; BAC13045; BAC13045.
GeneIDi1017056.
KEGGioih:OB1089.
PATRICi22793182. VBIOceIhe82024_1108.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000028 Genomic DNA. Translation: BAC13045.1 .
RefSeqi NP_692010.1. NC_004193.1.
WP_011065490.1. NC_004193.1.

3D structure databases

ProteinModelPortali Q8CUL8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 221109.OB1089.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC13045 ; BAC13045 ; BAC13045 .
GeneIDi 1017056.
KEGGi oih:OB1089.
PATRICi 22793182. VBIOceIhe82024_1108.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi GHQNANL.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci OIHE221109:GI2A-1165-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments."
    Takami H., Takaki Y., Uchiyama I.
    Nucleic Acids Res. 30:3927-3935(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

Entry informationi

Entry nameiODO1_OCEIH
AccessioniPrimary (citable) accession number: Q8CUL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3