Q8CU41 (OTCC1_STAES) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase 1, catabolic
Short name=OTCase 1
EC=2.1.3.3

Gene names

Name:	arcB1
Ordered Locus Names:	SE_0103

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Ornithine carbamoyltransferase 1, catabolic HAMAP MF_01109		PRO_0000113023
Regions
	Region	56 – 60	5	Carbamoyl phosphate binding By similarity
	Region	272 – 275	4	Ornithine binding By similarity
Sites
	Binding site	107	1	Carbamoyl phosphate By similarity
	Binding site	134	1	Carbamoyl phosphate By similarity
	Site	31	1	Important for structural integrity By similarity
	Site	147	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8CU41 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 83D9E9CEBAFBC373	FASTA	332	37,513
	10 20 30 40 50 60 MKNLRNRNFL TLLDFTQKEM EFLLNLSEDL KRAKYAGIEQ QKMKGKNIAL LFEKDSTRTR 70 80 90 100 110 120 CAFETAAYDQ GAHVTYLGPT GSQMGKKEST KDTARVLGGM YDGIEYRGFS QRVVEDLAKY 130 140 150 160 170 180 SGVPVWNGLT DEDHPTQVLA DFLTAKEVLK KPYNEINFTY VGDGRNNVAN ALMQGAAIMG 190 200 210 220 230 240 MTFHLVCPKE LNPTDELLNR CNDIADKNGG EILITDDIDE GVKGSDVIYT DVWVSMGEPD 250 260 270 280 290 300 EVWEKRIKLL EPYRVTKELM KKTGNPHTIF EHCLPSFHDT ETIIGKQIQE KYGLTEMEVT 310 320 330 NEVFESEQSV VFQEAENRAH TIKAVMVATL GE

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015929 Genomic DNA. Translation: AAO03700.1.
RefSeq	NP_763658.1. NC_004461.1.
3D structure databases
ProteinModelPortal	Q8CU41.
SMR	Q8CU41. Positions 2-332.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CU41.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000040533; EBSTAP00000039166; EBSTAG00000040531.
GeneID	1056967.
GenomeReviews	Gene locus SE_0103 in contig AE015929_GR.
KEGG	sep:SE0103.
PATRIC	19606037. VBIStaEpi113981_0097.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0078.
GeneTree	EBGT00050000023906.
HOGENOM	HBG579429.
OMA	MTPYQIN.
PhylomeDB	Q8CU41.
ProtClustDB	PRK04284.
Enzyme and pathway databases
BioCyc	SEPI176280:SE_0103-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
KO	K00611.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTCC1_STAES

Accession

Primary (citable) accession number: Q8CU41

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program