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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei255ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSEPI176280:G1G05-292-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:SE_0290
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001196571 – 484Glutamate--tRNA ligaseAdd BLAST484

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi176280.SE0290

Structurei

3D structure databases

ProteinModelPortaliQ8CTU3
SMRiQ8CTU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 21"HIGH" regionUniRule annotationAdd BLAST11
Motifi252 – 256"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
KOiK09698
OMAiAYYAFDT

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CTU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSERIRVRYA PSPTGYLHIG NARTALFNYL FAKHYNGDFV VRIEDTDSKR
60 70 80 90 100
NLEDGESSQF DNLKWLGLDW DESVDKDKGF GPYRQSERAE IYNPLIQQLL
110 120 130 140 150
EEDKAYKCYM TEEELEAERE AQIARGEMPR YGGQHAHLTE EQRQQYEAEG
160 170 180 190 200
RKPSIRFRVP KDQTYTFNDM VKGEISFESD NIGDWVIVKK DGVPTYNFAV
210 220 230 240 250
AVDDHYMQIS DVIRGDDHVS NTPKQLMIYE AFGWEAPRFG HMSLIVNEER
260 270 280 290 300
KKLSKRDGQI LQFIEQYRDL GYLPEALFNF ITLLGWSPEG EEEIFSKEEF
310 320 330 340 350
IKIFDEKRLS KSPAMFDRQK LAWVNNQYMK TKDTETVFEL ALPHLIKANL
360 370 380 390 400
IPENPSEKDR EWGRKLIALY QKEMSYAGEI VPLSEMFFHE MPELGKDEQE
410 420 430 440 450
VLQGEQVPEL MNHLYGKLES LESFEATEIK KMIKEVQKET GIKGKQLFMP
460 470 480
IRVAVTGQMH GPELPNTIEV LGKDKVLSRL KNLV
Length:484
Mass (Da):56,370
Last modified:March 1, 2003 - v1
Checksum:i644A72F0C8B24FEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA Translation: AAO03887.1
RefSeqiNP_763845.1, NC_004461.1
WP_002438667.1, NC_004461.1

Genome annotation databases

EnsemblBacteriaiAAO03887; AAO03887; SE_0290
GeneIDi1058062
KEGGisep:SE0290
PATRICifig|176280.10.peg.266

Similar proteinsi

Entry informationi

Entry nameiSYE_STAES
AccessioniPrimary (citable) accession number: Q8CTU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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