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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei176May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciSEPI176280:G1G05-339-MONOMER
UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:SE_0337
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001477301 – 292GTP cyclohydrolase FolE2Add BLAST292

Proteomic databases

PRIDEiQ8CTR6

Interactioni

Protein-protein interaction databases

STRINGi176280.SE0337

Structurei

3D structure databases

ProteinModelPortaliQ8CTR6
SMRiQ8CTR6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
KOiK09007
OMAiHNQRGRG

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit
TIGRFAMsiTIGR00294 TIGR00294, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CTR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEFDLSTRE GRWKHFGSVD PVKGTKPTTK NEMTDLQSTH KNFLFEIEEV
60 70 80 90 100
GIKNLTYPVL IDQYQTAGLF SFSTSLNKNE KGINMSRILE SVEKHYDNGI
110 120 130 140 150
ELEFNTLHQL LRTLQDKMNQ NAAGVDVSGK WFFDRYSPVT NIKAVGHADV
160 170 180 190 200
TYGLAIENHT VTRKELTIQA KVTTLCPCSK EISEYSAHNQ RGIVTVKAYL
210 220 230 240 250
DKNNDVIDDY KDKILDAMEA NASSILYPIL KRPDEKRVTE RAYENPRFVE
260 270 280 290
DLIRLIAADL VEFDWIEGFD IECRNEESIH QHDAFARLKY RK
Length:292
Mass (Da):33,634
Last modified:March 1, 2003 - v1
Checksum:iF381EB4BE1C3E6AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA Translation: AAO03934.1
RefSeqiNP_763892.1, NC_004461.1
WP_001832035.1, NC_004461.1

Genome annotation databases

EnsemblBacteriaiAAO03934; AAO03934; SE_0337
GeneIDi1056801
KEGGisep:SE0337
PATRICifig|176280.10.peg.310

Similar proteinsi

Entry informationi

Entry nameiGCH4_STAES
AccessioniPrimary (citable) accession number: Q8CTR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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