Q8CTR6 (GCH4_STAES) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase folE2
EC=3.5.4.16

Gene names

Name:	folE2
Ordered Locus Names:	SE_0337

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus epidermidis

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527
Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527
Sequence similarities	Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 292	292	GTP cyclohydrolase folE2 HAMAP-Rule MF_01527		PRO_0000147730
Sites
	Site	176	1	May be catalytically important By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8CTR6 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: F381EB4BE1C3E6AC	FASTA	292	33,634
	10 20 30 40 50 60 MTEFDLSTRE GRWKHFGSVD PVKGTKPTTK NEMTDLQSTH KNFLFEIEEV GIKNLTYPVL 70 80 90 100 110 120 IDQYQTAGLF SFSTSLNKNE KGINMSRILE SVEKHYDNGI ELEFNTLHQL LRTLQDKMNQ 130 140 150 160 170 180 NAAGVDVSGK WFFDRYSPVT NIKAVGHADV TYGLAIENHT VTRKELTIQA KVTTLCPCSK 190 200 210 220 230 240 EISEYSAHNQ RGIVTVKAYL DKNNDVIDDY KDKILDAMEA NASSILYPIL KRPDEKRVTE 250 260 270 280 290 RAYENPRFVE DLIRLIAADL VEFDWIEGFD IECRNEESIH QHDAFARLKY RK

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015929 Genomic DNA. Translation: AAO03934.1.
RefSeq	NP_763892.1. NC_004461.1.
3D structure databases
ProteinModelPortal	Q8CTR6.
ModBase	Search...
Protein-protein interaction databases
STRING	176280.SE0337.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO03934; AAO03934; SE_0337.
GeneID	1056801.
KEGG	sep:SE0337.
PATRIC	19606463. VBIStaEpi113981_0310.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1469.
KO	K09007.
OMA	INMYVDL.
ProtClustDB	PRK13674.
Enzyme and pathway databases
BioCyc	SEPI176280:GCDG-339-MONOMER.
UniPathway	UPA00848; UER00151.
Family and domain databases
Gene3D	3.10.270.10. 1 hit.
HAMAP	MF_01527_B. GTP_cyclohydrol_B.
InterPro	IPR022838. GTP_cyclohydrolase_FolE2. IPR003801. GTP_cyclohydrolase_FolE2/MptA. IPR002042. Uricase. [Graphical view]
Pfam	PF02649. GCHY-1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00294. TIGR00294. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCH4_STAES

Accession

Primary (citable) accession number: Q8CTR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	March 1, 2003
Last modified:	May 29, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program