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Q8CTR6

- GCH4_STAES

UniProt

Q8CTR6 - GCH4_STAES

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, SE_0337
Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei176 – 1761May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSEPI176280:GCDG-339-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:SE_0337
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001411: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292GTP cyclohydrolase FolE2UniRule annotation
PRO_0000147730Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176280.SE0337.

Structurei

3D structure databases

ProteinModelPortaliQ8CTR6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
KOiK09007.
OMAiAKWFFDR.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CTR6-1 [UniParc]FASTAAdd to Basket

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MTEFDLSTRE GRWKHFGSVD PVKGTKPTTK NEMTDLQSTH KNFLFEIEEV    50
GIKNLTYPVL IDQYQTAGLF SFSTSLNKNE KGINMSRILE SVEKHYDNGI 100
ELEFNTLHQL LRTLQDKMNQ NAAGVDVSGK WFFDRYSPVT NIKAVGHADV 150
TYGLAIENHT VTRKELTIQA KVTTLCPCSK EISEYSAHNQ RGIVTVKAYL 200
DKNNDVIDDY KDKILDAMEA NASSILYPIL KRPDEKRVTE RAYENPRFVE 250
DLIRLIAADL VEFDWIEGFD IECRNEESIH QHDAFARLKY RK 292
Length:292
Mass (Da):33,634
Last modified:March 1, 2003 - v1
Checksum:iF381EB4BE1C3E6AC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO03934.1.
RefSeqiNP_763892.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO03934; AAO03934; SE_0337.
GeneIDi1056801.
KEGGisep:SE0337.
PATRICi19606463. VBIStaEpi113981_0310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO03934.1 .
RefSeqi NP_763892.1. NC_004461.1.

3D structure databases

ProteinModelPortali Q8CTR6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 176280.SE0337.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO03934 ; AAO03934 ; SE_0337 .
GeneIDi 1056801.
KEGGi sep:SE0337.
PATRICi 19606463. VBIStaEpi113981_0310.

Phylogenomic databases

eggNOGi COG1469.
KOi K09007.
OMAi AKWFFDR.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci SEPI176280:GCDG-339-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
    Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
    Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12228.

Entry informationi

Entry nameiGCH4_STAES
AccessioniPrimary (citable) accession number: Q8CTR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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