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Q8CTR6

- GCH4_STAES

UniProt

Q8CTR6 - GCH4_STAES

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei176 – 1761May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciSEPI176280:GCDG-339-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:SE_0337
    OrganismiStaphylococcus epidermidis (strain ATCC 12228)
    Taxonomic identifieri176280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001411: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292GTP cyclohydrolase FolE2PRO_0000147730Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi176280.SE0337.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CTR6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    KOiK09007.
    OMAiAKWFFDR.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8CTR6-1 [UniParc]FASTAAdd to Basket

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    MTEFDLSTRE GRWKHFGSVD PVKGTKPTTK NEMTDLQSTH KNFLFEIEEV    50
    GIKNLTYPVL IDQYQTAGLF SFSTSLNKNE KGINMSRILE SVEKHYDNGI 100
    ELEFNTLHQL LRTLQDKMNQ NAAGVDVSGK WFFDRYSPVT NIKAVGHADV 150
    TYGLAIENHT VTRKELTIQA KVTTLCPCSK EISEYSAHNQ RGIVTVKAYL 200
    DKNNDVIDDY KDKILDAMEA NASSILYPIL KRPDEKRVTE RAYENPRFVE 250
    DLIRLIAADL VEFDWIEGFD IECRNEESIH QHDAFARLKY RK 292
    Length:292
    Mass (Da):33,634
    Last modified:March 1, 2003 - v1
    Checksum:iF381EB4BE1C3E6AC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015929 Genomic DNA. Translation: AAO03934.1.
    RefSeqiNP_763892.1. NC_004461.1.

    Genome annotation databases

    EnsemblBacteriaiAAO03934; AAO03934; SE_0337.
    GeneIDi1056801.
    KEGGisep:SE0337.
    PATRICi19606463. VBIStaEpi113981_0310.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015929 Genomic DNA. Translation: AAO03934.1 .
    RefSeqi NP_763892.1. NC_004461.1.

    3D structure databases

    ProteinModelPortali Q8CTR6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176280.SE0337.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO03934 ; AAO03934 ; SE_0337 .
    GeneIDi 1056801.
    KEGGi sep:SE0337.
    PATRICi 19606463. VBIStaEpi113981_0310.

    Phylogenomic databases

    eggNOGi COG1469.
    KOi K09007.
    OMAi AKWFFDR.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci SEPI176280:GCDG-339-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
      Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
      Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 12228.

    Entry informationi

    Entry nameiGCH4_STAES
    AccessioniPrimary (citable) accession number: Q8CTR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3