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Q8CTN9 (SYR_STAES) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:SE_0380
OrganismStaphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]
Taxonomic identifier176280 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 553553Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000151611

Regions

Motif130 – 14011"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q8CTN9 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: EB776F5242F36AB1

FASTA55362,535
        10         20         30         40         50         60 
MNIIDQVKQT LIEEIEASIR KANLAEDIPE IKIEIPKDTK NGDYSSNIAM VLTKIAKRNP 

        70         80         90        100        110        120 
REIAQAIVDH LDTSKAHVKQ VDIAGPGFIN FYLDNQYLTD IIPEAITKGD RFGYATQSKN 

       130        140        150        160        170        180 
TNILLEYVSA NPTGDLHIGH ARNAAVGDSL ANILIAAGYN VTREYYINDA GNQITNLARS 

       190        200        210        220        230        240 
IEARYFEALG DTSYEMPADG YNGKDIIEIG KDLAVKHPEI KDYSDEERLK TFRQLGVDYE 

       250        260        270        280        290        300 
MEKLKKDLSD FNVHFDNWFS ETSLYENGAI KNTLSKMKEL GYTYEADGAT WLRTSDFKDD 

       310        320        330        340        350        360 
KDRVLIKKDG NYTYFTPDTA YHYNKINRGN DILIDLMGAD HHGYINRLKA SLETFGVDSD 

       370        380        390        400        410        420 
RLEIQIMQMV RLMQNGEEVK MSKRTGNAIT LREIMDEVGI DAARYFLTMR SPDSHFDFDL 

       430        440        450        460        470        480 
ELAKEQSQDN PIYYAQYAHA RICSILKQAK EQGIEVSTDA DFSKINNDKA IDLLKKVAEF 

       490        500        510        520        530        540 
ESTIESAAEH RAPHRLTNYI QDLAAAFHKF YNAEKVLTDD TEKTKAHVAM IEAVRITLHN 

       550 
ALALVGVTAP ESM 

« Hide

References

[1]"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12228.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015929 Genomic DNA. Translation: AAO03977.1.
RefSeqNP_763935.1. NC_004461.1.

3D structure databases

ProteinModelPortalQ8CTN9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176280.SE0380.

Protocols and materials databases

DNASU1056748.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO03977; AAO03977; SE_0380.
GeneID1056748.
KEGGsep:SE0380.
PATRIC19606551. VBIStaEpi113981_0354.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
KOK01887.
OMALCNVLAK.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycSEPI176280:GCDG-382-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_STAES
AccessionPrimary (citable) accession number: Q8CTN9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries