Reviewed,
UniProtKB/Swiss-Prot Q8CT28 (PUR3_STAES)
Last modified
November 3, 2009.
Version 46.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Phosphoribosylglycinamide formyltransferase EC=2.1.2.2 Alternative name(s): 5'-phosphoribosylglycinamide transformylase GAR transformylase Short name=GART | ||||
| Gene names |
| ||||
| Organism | Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 176280 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Staphylococcus |
Protein attributes
| Sequence length | 188 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide. |
| Pathway | |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the GART family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine biosynthesis |
| Molecular function | Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | 'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | phosphoribosylglycinamide formyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 188 | 188 | Phosphoribosylglycinamide formyltransferase | PRO_0000074951 | |||||
Regions | |||||||||
| Region | 12 – 14 | 3 | 5'-phosphoribosylglycinamide binding By similarity | ||||||
| Region | 91 – 94 | 4 | 10-formyltetrahydrofolate binding By similarity | ||||||
Sites | |||||||||
| Active site | 110 | 1 | Proton donor By similarity | ||||||
| Binding site | 66 | 1 | 10-formyltetrahydrofolate By similarity | ||||||
| Binding site | 108 | 1 | 10-formyltetrahydrofolate By similarity | ||||||
| Binding site | 146 | 1 | 10-formyltetrahydrofolate; via amide nitrogen By similarity | ||||||
| Binding site | 175 | 1 | 5'-phosphoribosylglycinamide By similarity | ||||||
| Site | 146 | 1 | Raises pKa of active site His By similarity | ||||||
Sequences
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References
| [1] | "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| AE015929 Genomic DNA. Translation: AAO04367.1. | |
| RefSeq | NP_764325.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1JKX based on UniProtKB P08179. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8CT28. |
Genome annotation databases | |
| GeneID | 1056737. |
| GenomeReviews | Gene locus SE_0770 in contig AE015929_GR. |
| KEGG | sep:SE0770. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q8CT28. |
| OMA | LASWRGT. |
Enzyme and pathway databases | |
| BioCyc | SEPI176280:SE_0770-MON. |
Family and domain databases | |
| InterPro | IPR002376. Formyl_transf_N. IPR001555. GART_AS. IPR004607. PurN_trans. [Graphical view] |
| Gene3D | G3DSA:3.40.50.170. Formyl_transf_N. 1 hit. |
| Pfam | PF00551. Formyl_trans_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00639. PurN. 1 hit. |
| PROSITE | PS00373. GART. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PUR3_STAES | ||||||||
| Accession | Primary (citable) accession number: Q8CT28 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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