Q8CST9 (CDSA_STAES) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidate cytidylyltransferase
EC=2.7.7.41

Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name=CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase

Gene names

Name:	cdsA
Ordered Locus Names:	SE_0937

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 260	260	Phosphatidate cytidylyltransferase		PRO_0000090753
Regions
	Transmembrane	9 – 29	21	Helical; Potential
	Transmembrane	46 – 66	21	Helical; Potential
	Transmembrane	70 – 90	21	Helical; Potential
	Transmembrane	102 – 122	21	Helical; Potential
	Transmembrane	130 – 150	21	Helical; Potential
	Transmembrane	172 – 192	21	Helical; Potential
	Transmembrane	196 – 216	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8CST9 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: B52A542C097449B9	FASTA	260	29,179
	10 20 30 40 50 60 MKVRTLTAII ALLIFLPILL KGGLILMLFA FLLALIALKE LLNMNMIKFL SIPGLISALA 70 80 90 100 110 120 LIIIMLPQDA GEWVQVIQLK GLIAMSFIVL SYTVLSKNRF SFMDAAFCLM SVAYVGIGFM 130 140 150 160 170 180 YFYETRSEGL RYILFAFLIV WLTDTGAYIF GRLMGKHKLW PVISPNKTIE GFFGGILCSI 190 200 210 220 230 240 LVPLVMQMFV DLHMNIWLLL LVTIVLSMFG QLGDLVESGF KRHFGVKDSG RILPGHGGIL 250 260 DRFDSFMFVL PLLNILLIQT

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015929 Genomic DNA. Translation: AAO04534.1.
RefSeq	NP_764492.1. NC_004461.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CST9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000041257; EBSTAP00000039890; EBSTAG00000041255.
GeneID	1057582.
GenomeReviews	Gene locus SE_0937 in contig AE015929_GR.
KEGG	sep:SE0937.
PATRIC	19607677. VBIStaEpi113981_0912.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0575.
GeneTree	EBGT00050000025310.
HOGENOM	HBG732679.
OMA	WILLIPS.
ProtClustDB	CLSK885236.
Enzyme and pathway databases
BioCyc	SEPI176280:SE_0937-MONOMER.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
KO	K00981.
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_STAES

Accession

Primary (citable) accession number: Q8CST9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program