Reviewed, UniProtKB/Swiss-Prot Q8CST9 (CDSA_STAES)

Names and origin

Protein names

Recommended name:
    Phosphatidate cytidylyltransferase
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthase
    CDP-diacylglycerol synthase
      Short name=CDS
    CTP:phosphatidate cytidylyltransferase
    CDP-DG synthase
    CDP-DAG synthase

Gene names

Name:	cdsA
Ordered Locus Names:	SE_0937

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 260	260	Phosphatidate cytidylyltransferase		PRO_0000090753
Regions
	Transmembrane	9 – 29	21	Potential
	Transmembrane	46 – 66	21	Potential
	Transmembrane	70 – 90	21	Potential
	Transmembrane	102 – 122	21	Potential
	Transmembrane	130 – 150	21	Potential
	Transmembrane	172 – 192	21	Potential
	Transmembrane	196 – 216	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8CST9-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: B52A542C097449B9	FASTA	260	29,179
	10 20 30 40 50 60 MKVRTLTAII ALLIFLPILL KGGLILMLFA FLLALIALKE LLNMNMIKFL SIPGLISALA 70 80 90 100 110 120 LIIIMLPQDA GEWVQVIQLK GLIAMSFIVL SYTVLSKNRF SFMDAAFCLM SVAYVGIGFM 130 140 150 160 170 180 YFYETRSEGL RYILFAFLIV WLTDTGAYIF GRLMGKHKLW PVISPNKTIE GFFGGILCSI 190 200 210 220 230 240 LVPLVMQMFV DLHMNIWLLL LVTIVLSMFG QLGDLVESGF KRHFGVKDSG RILPGHGGIL 250 260 DRFDSFMFVL PLLNILLIQT

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015929 Genomic DNA. Translation: AAO04534.1.
RefSeq	NP_764492.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CST9.
Genome annotation databases
GeneID	1057582.
GenomeReviews	Gene locus SE_0937 in contig AE015929_GR.
KEGG	sep:SE0937.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0575.
HOGENOM	HBG732679.
OMA	WILLIPS.
Enzyme and pathway databases
BioCyc	SEPI176280:SE_0937-MONOMER.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_STAES

Accession

Primary (citable) accession number: Q8CST9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
Last sequence update:	March 1, 2003
Last modified:	February 9, 2010
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)