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Protein

Signal transduction histidine-protein kinase ArlS

Gene

arlS

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system ArlS/ArlR. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR (By similarity).By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
Biological processTwo-component regulatory system
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transduction histidine-protein kinase ArlS (EC:2.7.13.3)
Gene namesi
Name:arlS
Ordered Locus Names:SE_1099
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002934491 – 456Signal transduction histidine-protein kinase ArlSAdd BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei243Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi176280.SE1099.

Structurei

3D structure databases

ProteinModelPortaliQ8CSL7.
SMRiQ8CSL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 232HAMPPROSITE-ProRule annotationAdd BLAST54
Domaini240 – 456Histidine kinasePROSITE-ProRule annotationAdd BLAST217

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105GR3. Bacteria.
COG0642. LUCA.
KOiK18940.
OMAiASSINQM.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiView protein in InterPro
IPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
PfamiView protein in Pfam
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiView protein in SMART
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiView protein in PROSITE
PS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CSL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKRQKLKYK WMLITTLITF TTILLFCLII IFFLKDTLRS SEIDEAERSS
60 70 80 90 100
NDIANLFHSK SLSDISALDL NASLENFQEI LIYDDKGRKL IQTSNDNTLA
110 120 130 140 150
YDNKIDFKHP ERIHIQRSHG INYLVITEPI RSKDFSGYSV LVHSLQNYDN
160 170 180 190 200
LVKSLYIVAL AFGLIATIIT AGVSYIFSSQ ITKPIVTMSN KMNQIRRDGF
210 220 230 240 250
QNKLELTTNY EETDNLIDTF NEMMYQIEES FNQQRQFVED ASHELRTPLQ
260 270 280 290 300
IIQGHLNLIQ RWGKKDPAVL EESLNISIEE VNRITKLVEE LLLLTKDRVN
310 320 330 340 350
HNVLECENVD VNSEIQSRVK SLQHLHPDYT FETHLATKPI QLKINRHQFE
360 370 380 390 400
QLLLIFIDNA MKYDTEHKHI KIVTQLKNKM IMIDITDHGM GIPKADLEFI
410 420 430 440 450
FDRFYRVDKS RARSQGGNGL GLSIAEKIVQ LNGGMIQVES ELQKYTTFKI

SFPVLN
Length:456
Mass (Da):52,860
Last modified:March 1, 2003 - v1
Checksum:i8ACF8A6CF9D7F77B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO04696.1.
RefSeqiNP_764654.1. NC_004461.1.
WP_001831043.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO04696; AAO04696; SE_1099.
GeneIDi1057471.
KEGGisep:SE1099.
PATRICi19608002. VBIStaEpi113981_1074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO04696.1.
RefSeqiNP_764654.1. NC_004461.1.
WP_001831043.1. NC_004461.1.

3D structure databases

ProteinModelPortaliQ8CSL7.
SMRiQ8CSL7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176280.SE1099.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO04696; AAO04696; SE_1099.
GeneIDi1057471.
KEGGisep:SE1099.
PATRICi19608002. VBIStaEpi113981_1074.

Phylogenomic databases

eggNOGiENOG4105GR3. Bacteria.
COG0642. LUCA.
KOiK18940.
OMAiASSINQM.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiView protein in InterPro
IPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
PfamiView protein in Pfam
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiView protein in SMART
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiView protein in PROSITE
PS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARLS_STAES
AccessioniPrimary (citable) accession number: Q8CSL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 1, 2003
Last modified: March 15, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.