Q8CSK6 (MSRB_STAES) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrB
EC=1.8.4.12

Alternative name(s):
Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	SE_1116

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Sequence similarities	Belongs to the MsrB Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	Peptide methionine sulfoxide reductase MsrB HAMAP MF_01400		PRO_0000140301
Sites
	Active site	114	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8CSK6 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 1FA44CE8ABB4E505	FASTA	142	16,416
	10 20 30 40 50 60 MIKKNKEELN DMEYLVTQEN GTEPPFQNEY WNHFEKGIYV DKLSGKPLFT SEDKFESNCG 70 80 90 100 110 120 WPSFSKALND DEIVELVDKS FGMIRTEVRS EKANSHLGHV FNDGPKEKGG LRYCINSAAI 130 140 QFIPYDKLEE LGYGDLIKHF KK

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015929 Genomic DNA. Translation: AAO04713.1.
RefSeq	NP_764671.1. NC_004461.1.
3D structure databases
ProteinModelPortal	Q8CSK6.
SMR	Q8CSK6. Positions 5-142.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CSK6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000039440; EBSTAP00000038073; EBSTAG00000039438.
GeneID	1057482.
GenomeReviews	Gene locus SE_1116 in contig AE015929_GR.
KEGG	sep:SE1116.
PATRIC	19608032. VBIStaEpi113981_1089.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0229.
GeneTree	EBGT00050000024012.
HOGENOM	HBG715255.
OMA	FTDGPVD.
PhylomeDB	Q8CSK6.
ProtClustDB	PRK00222.
Enzyme and pathway databases
BioCyc	SEPI176280:SE_1116-MONOMER.
Family and domain databases
HAMAP	MF_01400. MsrB. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
KO	K07305.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
SUPFAM	SSF51316. Mss4_like. 1 hit.
TIGRFAMs	TIGR00357. TIGR00357. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_STAES

Accession

Primary (citable) accession number: Q8CSK6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program