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Protein

Demethylmenaquinone methyltransferase

Gene

menG

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).UniRule annotation

Catalytic activityi

A demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: menaquinone biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 1,4-dihydroxy-2-naphthoate octaprenyltransferase (menA)
  2. Demethylmenaquinone methyltransferase (menG)
This subpathway is part of the pathway menaquinone biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate, the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei60 – 601S-adenosyl-L-methionineUniRule annotation
Binding sitei81 – 811S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Menaquinone biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciSEPI176280:GCDG-1164-MONOMER.
UniPathwayiUPA00079; UER00169.

Names & Taxonomyi

Protein namesi
Recommended name:
Demethylmenaquinone methyltransferaseUniRule annotation (EC:2.1.1.163UniRule annotation)
Gene namesi
Name:menGUniRule annotation
Ordered Locus Names:SE_1158
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Demethylmenaquinone methyltransferasePRO_0000193333Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176280.SE1158.

Structurei

3D structure databases

ProteinModelPortaliQ8CSH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni106 – 1072S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DDZ. Bacteria.
COG2226. LUCA.
KOiK03183.
OMAiQKSALNC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01813. MenG_UbiE_methyltr. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CSH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENQAKKEQ VHTVFQNISQ KYDRLNNIIS FEQHKVWRKH VMSTMNVQKG
60 70 80 90 100
SKALDVCCGT ADWTIALSEA VGSKGQVTGL DFSENMLEVG KQKTASLENI
110 120 130 140 150
QLVHGDAMNL PFDDNSFDYV TIGFGLRNVP DYLSALKEMH RVLKPGGMVV
160 170 180 190 200
CLETSQPTLP LFKQIYSLYF KFVMPIFGKM FAKSKEEYEW LQQSTFNFPD
210 220 230 240
KQTLKGLFFE AGFNDIIVRS FTGGVAAMHL GYKENSSSKG D
Length:241
Mass (Da):27,194
Last modified:March 1, 2003 - v1
Checksum:i38A3332D6273CDEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO04755.1.
RefSeqiNP_764713.1. NC_004461.1.
WP_001831089.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO04755; AAO04755; SE_1158.
GeneIDi1055893.
KEGGisep:SE1158.
PATRICi19608114. VBIStaEpi113981_1130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO04755.1.
RefSeqiNP_764713.1. NC_004461.1.
WP_001831089.1. NC_004461.1.

3D structure databases

ProteinModelPortaliQ8CSH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176280.SE1158.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO04755; AAO04755; SE_1158.
GeneIDi1055893.
KEGGisep:SE1158.
PATRICi19608114. VBIStaEpi113981_1130.

Phylogenomic databases

eggNOGiENOG4105DDZ. Bacteria.
COG2226. LUCA.
KOiK03183.
OMAiQKSALNC.

Enzyme and pathway databases

UniPathwayiUPA00079; UER00169.
BioCyciSEPI176280:GCDG-1164-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01813. MenG_UbiE_methyltr. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMENG_STAES
AccessioniPrimary (citable) accession number: Q8CSH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.