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Q8CS69

- KPYK_STAES

UniProt

Q8CS69 - KPYK_STAES

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Protein
Pyruvate kinase
Gene
pyk, SE_1373
Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Magnesium By similarity.
Potassium By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei32 – 321Substrate By similarity
Metal bindingi34 – 341Potassium By similarity
Metal bindingi36 – 361Potassium By similarity
Metal bindingi66 – 661Potassium By similarity
Metal bindingi67 – 671Potassium; via carbonyl oxygen By similarity
Sitei219 – 2191Transition state stabilizer By similarity
Metal bindingi221 – 2211Magnesium By similarity
Binding sitei244 – 2441Substrate; via amide nitrogen By similarity
Metal bindingi245 – 2451Magnesium By similarity
Binding sitei245 – 2451Substrate; via amide nitrogen By similarity
Binding sitei277 – 2771Substrate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

BioCyciSEPI176280:GCDG-1379-MONOMER.
UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:pyk
Ordered Locus Names:SE_1373
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001411: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Pyruvate kinase
PRO_0000294137Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176280.SE1373.

Structurei

3D structure databases

ProteinModelPortaliQ8CS69.
SMRiQ8CS69. Positions 2-585.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.
In the C-terminal section; belongs to the PEP-utilizing enzyme family.

Phylogenomic databases

eggNOGiCOG0469.
KOiK00873.
OMAiGTHEEHK.
OrthoDBiEOG6GBMB0.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
3.50.30.10. 1 hit.
InterProiIPR008279. PEP-util_enz_mobile_dom.
IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00391. PEP-utilizers. 1 hit.
PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52009. SSF52009. 1 hit.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CS69-1 [UniParc]FASTAAdd to Basket

« Hide

MRKTKIVCTI GPASESEEML EKLMNAGMNV ARLNFSHGSH EEHKARIDTI    50
RKVAKRLNKT IGLLLDTKGP EIRTHNMKDG LIVLEKGKEV IVSMNEVEGT 100
PEKFSVTYEN LINDVNIGSY ILLDDGLVEL QVKEINKDKG EVKCDILNTG 150
ELKNKKGVNL PGVKVNLPGI TDKDADDIRF GIKENVDFIA ASFVRRPSDV 200
LDIRQILEEE KAEITIFPKI ENQEGIDNIE EILEVSDGLM VARGDMGVEI 250
PPESVPMVQK DLIRKCNKLG KPVITATQML DSMQRNPRAT RAEASDVANA 300
IYDGTDAVML SGETAAGQYP EEAVKTMRNI AVSAEAAQDY KKLLSDRTKL 350
VETSLVNAIG VSVAHTALNL NVKAIVAATE SGSTARTISK YRPHSDIIAV 400
TPSEKTARQC AIVWGVNPVV KEGRKTTDAL LNNAVATAVE TGRVSNGDLI 450
IITAGVPTGE KGTTNMMKIH LVGDEIAKGQ GVGRGSVVGH AIVADSASDL 500
EGKDLSDKVI ITNSVDETLV PYVEKAIGLI TEENGITSPS AIIGLEKGIP 550
TVVGVEQATK EIKNDMLVTL DASQGKVFEG YANVL 585
Length:585
Mass (Da):63,033
Last modified:March 1, 2003 - v1
Checksum:i7756EDD80D49128C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO04972.1.
RefSeqiNP_764928.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO04972; AAO04972; SE_1373.
GeneIDi1058009.
KEGGisep:SE1373.
PATRICi19608536. VBIStaEpi113981_1341.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO04972.1 .
RefSeqi NP_764928.1. NC_004461.1.

3D structure databases

ProteinModelPortali Q8CS69.
SMRi Q8CS69. Positions 2-585.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176280.SE1373.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO04972 ; AAO04972 ; SE_1373 .
GeneIDi 1058009.
KEGGi sep:SE1373.
PATRICi 19608536. VBIStaEpi113981_1341.

Phylogenomic databases

eggNOGi COG0469.
KOi K00873.
OMAi GTHEEHK.
OrthoDBi EOG6GBMB0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .
BioCyci SEPI176280:GCDG-1379-MONOMER.

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
3.50.30.10. 1 hit.
InterProi IPR008279. PEP-util_enz_mobile_dom.
IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00391. PEP-utilizers. 1 hit.
PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52009. SSF52009. 1 hit.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
    Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
    Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12228.

Entry informationi

Entry nameiKPYK_STAES
AccessioniPrimary (citable) accession number: Q8CS69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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