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Protein

Acetate kinase

Gene

ackA

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9MagnesiumUniRule annotation1
Binding sitei16ATPUniRule annotation1
Binding sitei90SubstrateUniRule annotation1
Active sitei147Proton donor/acceptorUniRule annotation1
Sitei179Transition state stabilizerUniRule annotation1
Sitei240Transition state stabilizerUniRule annotation1
Metal bindingi384MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi207 – 211ATPUniRule annotation5
Nucleotide bindingi282 – 284ATPUniRule annotation3
Nucleotide bindingi330 – 334ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:SE_1387
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001076161 – 417Acetate kinaseAdd BLAST417

Proteomic databases

PRIDEiQ8CS60.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi176280.SE1387.

Structurei

3D structure databases

ProteinModelPortaliQ8CS60.
SMRiQ8CS60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H. Bacteria.
COG0282. LUCA.
KOiK00925.
OMAiWKALTGT.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 1 hit.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CS60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLILAVNA GSSSLKFQLI KMPEEKLVTK GVIERIGLSD SIFTIHVNGE
60 70 80 90 100
KLTDIRDIHN HEEAVNIMLD SFKEHEMIKD ITDIQGTGHR VVHGGETFPK
110 120 130 140 150
SVVVTDEVES QIEELSELAP LHNPANLMGI RAFRKLLPEI PHVAVFDTSF
160 170 180 190 200
HQTMPEQAYL YSLPYHYYED YGIRKYGFHG TSHKYVSRRA AQIVGRPIED
210 220 230 240 250
LRIISCHIGN GASIAAIDGG ESIDTSMGFT PLAGVTMGTR SGNLDPALIP
260 270 280 290 300
FIMEKTGKTA DEVLEILNKE SGLLGLTGTS SDLRDLTEEA KHGRQRSRVA
310 320 330 340 350
LDLFASKIHK YIGSYAARMH GVDVIVFTAG IGENSHIIRG KVLEGLEFMG
360 370 380 390 400
VYWDPKKNES LHGEEGYINY PHSPVKVLVV PTDEEVMISR DVIKYGKLND
410
NTPKKEEFDT NESIEVN
Length:417
Mass (Da):46,338
Last modified:March 1, 2003 - v1
Checksum:iD0312D8184361206
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO04986.1.
RefSeqiNP_764942.1. NC_004461.1.
WP_001830869.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO04986; AAO04986; SE_1387.
GeneIDi1056464.
KEGGisep:SE1387.
PATRICifig|176280.10.peg.1355.

Similar proteinsi

Entry informationi

Entry nameiACKA_STAES
AccessioniPrimary (citable) accession number: Q8CS60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 1, 2003
Last modified: June 7, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families