Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8CRN9 (THIM_STAES) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:SE_1691
OrganismStaphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]
Taxonomic identifier176280 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000156958

Sites

Binding site391Substrate; via amide nitrogen By similarity
Binding site1151ATP By similarity
Binding site1601ATP By similarity
Binding site1871Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CRN9 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: A55A929C59B80129

FASTA26228,388
        10         20         30         40         50         60 
MNNLERLRSE NPLVICYTND VVKNFTANGL LSLGASPAMS EAPEEAEDFT RMASALLINI 

        70         80         90        100        110        120 
GTLTRENEED IIKIGKIANQ QGTPIVFDPV AVGASTYRKN FCQRFLGEVN VTVIKGNASE 

       130        140        150        160        170        180 
ILTLIDFNTT MKGTDSDSEL DSVNIAKKAA NTLNTAIVIT GKDDIIAKNE KIIKLSNGSP 

       190        200        210        220        230        240 
LLTKITGAGC LLGGVLASFL FRNTQPSIDL LVEAVSVYNI AAEFAEQAPH VNGPSTFLSE 

       250        260 
LLDQLYQMND ITYKNQVKKV EI 

« Hide

References

[1]"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12228.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015929 Genomic DNA. Translation: AAO05290.1.
RefSeqNP_765246.1. NC_004461.1.

3D structure databases

ProteinModelPortalQ8CRN9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176280.SE1691.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO05290; AAO05290; SE_1691.
GeneID1057331.
KEGGsep:SE1691.
PATRIC19609244. VBIStaEpi113981_1651.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
KOK00878.
OMARICIQEV.
OrthoDBEOG628F8M.

Enzyme and pathway databases

BioCycSEPI176280:GCDG-1741-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_STAES
AccessionPrimary (citable) accession number: Q8CRN9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways