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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei596For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:SE_1751
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001353852 – 601Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST600

Proteomic databases

PRIDEiQ8CRL1.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi176280.SE1751.

Structurei

3D structure databases

ProteinModelPortaliQ8CRL1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 218Glutamine amidotransferase type-2UniRule annotationAdd BLAST217
Domaini284 – 423SIS 1UniRule annotationAdd BLAST140
Domaini453 – 591SIS 2UniRule annotationAdd BLAST139

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46. Bacteria.
COG0449. LUCA.
KOiK00820.
OMAiGEFFCAS.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CRL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGYIGY DNAKELLLKG LEKLEYRGYD SAGIAVVNDD GTKLFKEKGR
60 70 80 90 100
IAELRKVADN SDEDGTLGIG HTRWATHGVP NYENSHPHQS TSGRFTLVHN
110 120 130 140 150
GVIENYEELK AEYLSDVTFS SETDTEVIVQ LVDYFSRQGL ATEDAFTKVV
160 170 180 190 200
KLLHGSYALG LLDDNDKDTI YVAKNKSPLL VGVGEGFNVI ASDALAMLQT
210 220 230 240 250
TNQYKEIHDH EIVIVKRDTV EIKDLEGHIQ QRDTYTAEID AADAEKGVYD
260 270 280 290 300
HYMLKEIHEQ PAVMRRIIQE YQDEKGNLKI DSEIINDVAD ADRIYIVAAG
310 320 330 340 350
TSYHAGLVGK EFIEKWAGVP TEVHVASEFV YNMPLLSEKP LFIYISQSGE
360 370 380 390 400
TADSRAVLVE TNKLGHKSLT ITNVAGSTLS READHTLLLH AGPEIAVAST
410 420 430 440 450
KAYTAQIAVL SILSQIVAKN HGRETDVDLL RELAKVTTAI ETIVDDAPKM
460 470 480 490 500
EQIATDFLKT TRNAFFIGRT IDYNVSLEGA LKLKEISYIQ AEGFAGGELK
510 520 530 540 550
HGTIALIEDG TPVIGLATQE NVNLSIRGNM KEVVARGAYP CMISMEGLNK
560 570 580 590 600
EGDTYVIPQV HELLTPLVSV VTMQLISYYA ALQRDLDVDK PRNLAKSVTV

E
Length:601
Mass (Da):66,237
Last modified:January 23, 2007 - v3
Checksum:iF0E939D5248DC960
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO05350.1.
RefSeqiNP_765306.1. NC_004461.1.
WP_001829889.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO05350; AAO05350; SE_1751.
GeneIDi1057710.
KEGGisep:SE1751.
PATRICi19609362. VBIStaEpi113981_1710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO05350.1.
RefSeqiNP_765306.1. NC_004461.1.
WP_001829889.1. NC_004461.1.

3D structure databases

ProteinModelPortaliQ8CRL1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176280.SE1751.

Protein family/group databases

MEROPSiC44.971.

Proteomic databases

PRIDEiQ8CRL1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO05350; AAO05350; SE_1751.
GeneIDi1057710.
KEGGisep:SE1751.
PATRICi19609362. VBIStaEpi113981_1710.

Phylogenomic databases

eggNOGiENOG4105C46. Bacteria.
COG0449. LUCA.
KOiK00820.
OMAiGEFFCAS.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLMS_STAES
AccessioniPrimary (citable) accession number: Q8CRL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.