Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Polyphosphate kinase

Gene

ppk

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).UniRule annotation

Catalytic activityi

ATP + (phosphate)(n) = ADP + (phosphate)(n+1).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei67ATPUniRule annotation1
Metal bindingi392MagnesiumUniRule annotation1
Metal bindingi422MagnesiumUniRule annotation1
Active sitei452Phosphohistidine intermediateUniRule annotation1
Binding sitei485ATPUniRule annotation1
Binding sitei581ATPUniRule annotation1
Binding sitei609ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyphosphate kinaseUniRule annotation (EC:2.7.4.1UniRule annotation)
Alternative name(s):
ATP-polyphosphate phosphotransferaseUniRule annotation
Polyphosphoric acid kinaseUniRule annotation
Gene namesi
Name:ppkUniRule annotation
Ordered Locus Names:SE_2034
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001286571 – 734Polyphosphate kinaseAdd BLAST734

Post-translational modificationi

An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi176280.SE2034.

Structurei

3D structure databases

ProteinModelPortaliQ8CR71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini447 – 481PLD phosphodiesteraseUniRule annotationAdd BLAST35

Sequence similaritiesi

Belongs to the polyphosphate kinase family.UniRule annotation
Contains 1 PLD phosphodiesterase domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CUU. Bacteria.
COG0855. LUCA.
KOiK00937.
OMAiLSSMIHA.

Family and domain databases

Gene3Di3.30.1840.10. 1 hit.
HAMAPiMF_00347. Polyphosphate_kinase. 1 hit.
InterProiIPR003414. PP_kinase.
IPR024953. PP_kinase_middle.
IPR025200. PPK_C_dom.
IPR025198. PPK_N_dom.
[Graphical view]
PfamiPF02503. PP_kinase. 1 hit.
PF13090. PP_kinase_C. 1 hit.
PF13089. PP_kinase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015589. PP_kinase. 1 hit.
SUPFAMiSSF140356. SSF140356. 1 hit.
TIGRFAMsiTIGR03705. poly_P_kin. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CR71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHNKDKLMRC MYSMQTRLGE KDINLPQYYN NRELSWLDFN YRVLQESYDK
60 70 80 90 100
NNPLLEKLNF ISIFSSNLDE FFMVRVAGLK DQVKMGYDKP ENKAQMTPQE
110 120 130 140 150
QLDAIKIKNT DYVNTQYQRY NELIKELANY DIEMVKPEDL SDALIEKLEQ
160 170 180 190 200
EFKLSVLPTL TPLGIDAYHP FPKLNNKSLN IFVDIDTEDA INSAIVQIPS
210 220 230 240 250
LIPRFLTLNE GTKQYVVMVE DVITYFINYL FTGYEVLNTF TFRITRNADL
260 270 280 290 300
TIHEDGAEDL LIEIERFLKE RKSGSAVRLE LDCRTSEKEN VEWLINQLEI
310 320 330 340 350
EDNDIYYLDG PLDLTFLFGL VDHLSHKLKY LTYEKYTPQP PRSLGNKNIY
360 370 380 390 400
QLSLERDIFF HHPYESFEPI VDFIRQAADD PNTIAIKQTL YRVSKDSPII
410 420 430 440 450
NSLKEAAENG KQVTVLVELK ARFDEENNVH WARMLEDAGC HVIYGMTHLK
460 470 480 490 500
THSKIALVVK RINNELTSFV HLGTGNYNDK TAKLYTDMGI ITTNKDIAED
510 520 530 540 550
AINFFNYLSG YSTKPEYNKL IVAPYDIRDV FIDRIDKEIR SHLQHGNGKI
560 570 580 590 600
MMKMNSLTDK TIIEKLFEAS QAGVKIQLII RGICCLKPGI PGISENIEVV
610 620 630 640 650
SIVGRLLEHS RIYYFHNNSE AHIYLSSADV MTRNMIKRVE ILFPVEDKSI
660 670 680 690 700
GQRLVNYMNL QLSDNQKGRY QDAQGLYHYV ENNSSPLNSQ SYLMQEAIKY
710 720 730
GEELKKQSVQ PSGQPVHSRR GGSWMRKLKN TFKR
Length:734
Mass (Da):85,205
Last modified:March 1, 2003 - v1
Checksum:iF18E4240DA68B56B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO05675.1.
RefSeqiNP_765589.1. NC_004461.1.
WP_011082793.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO05675; AAO05675; SE_2034.
GeneIDi1055973.
KEGGisep:SE2034.
PATRICi19609934. VBIStaEpi113981_1987.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO05675.1.
RefSeqiNP_765589.1. NC_004461.1.
WP_011082793.1. NC_004461.1.

3D structure databases

ProteinModelPortaliQ8CR71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176280.SE2034.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO05675; AAO05675; SE_2034.
GeneIDi1055973.
KEGGisep:SE2034.
PATRICi19609934. VBIStaEpi113981_1987.

Phylogenomic databases

eggNOGiENOG4105CUU. Bacteria.
COG0855. LUCA.
KOiK00937.
OMAiLSSMIHA.

Family and domain databases

Gene3Di3.30.1840.10. 1 hit.
HAMAPiMF_00347. Polyphosphate_kinase. 1 hit.
InterProiIPR003414. PP_kinase.
IPR024953. PP_kinase_middle.
IPR025200. PPK_C_dom.
IPR025198. PPK_N_dom.
[Graphical view]
PfamiPF02503. PP_kinase. 1 hit.
PF13090. PP_kinase_C. 1 hit.
PF13089. PP_kinase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015589. PP_kinase. 1 hit.
SUPFAMiSSF140356. SSF140356. 1 hit.
TIGRFAMsiTIGR03705. poly_P_kin. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPPK_STAES
AccessioniPrimary (citable) accession number: Q8CR71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.