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Q8CR67

- GTAB_STAES

UniProt

Q8CR67 - GTAB_STAES

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Protein
UTP--glucose-1-phosphate uridylyltransferase
Gene
gtaB, SE_2043
Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of UDP-glucose from glucose-1-phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. a glycolipid found in the membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) By similarity.

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathwayi

GO - Molecular functioni

  1. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. UDP-glucose metabolic process Source: InterPro
  2. enterobacterial common antigen biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

BioCyciSEPI176280:GCDG-2102-MONOMER.
UniPathwayiUPA00894.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Uridine diphosphoglucose pyrophosphorylase
Gene namesi
Name:gtaB
Ordered Locus Names:SE_2043
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001411: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288UTP--glucose-1-phosphate uridylyltransferase
PRO_0000308311Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176280.SE2043.

Structurei

3D structure databases

ProteinModelPortaliQ8CR67.

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.

Phylogenomic databases

eggNOGiCOG1210.
KOiK00963.
OrthoDBiEOG6Z9B3V.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01099. galU. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CR67-1 [UniParc]FASTAAdd to Basket

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MKKIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEASKAGI    50
EDIIIVTGKH KRAIEDHFDN QKELEMVLEN KGKADLLEKV QYSTDLANIF 100
YVRQKEQKGL GHAIHTAKQF IGNEPFAVLL GDDIVESDTP AIKQLMDVYE 150
ETGHSVIGVQ EVPESDTHRY GVIDPSAKEG SRYEVRQFVE KPKQGTAPSN 200
LAIMGRYVLT PEIFDYLETQ QEGAGNEIQL TDAIERMNSK QQVYAYDFEG 250
NRYDVGEKLG FVKTTIEYAL KDPEMSQDLK AFIKQLDI 288
Length:288
Mass (Da):32,424
Last modified:October 23, 2007 - v2
Checksum:iED5422E73E60672F
GO

Sequence cautioni

The sequence AAO05684.1 differs from that shown. Reason: Frameshift at position 30.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO05684.1. Frameshift.
RefSeqiNP_765598.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO05684; AAO05684; SE_2043.
GeneIDi1055993.
KEGGisep:SE2043.
PATRICi19609952. VBIStaEpi113981_1996.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO05684.1 . Frameshift.
RefSeqi NP_765598.1. NC_004461.1.

3D structure databases

ProteinModelPortali Q8CR67.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176280.SE2043.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO05684 ; AAO05684 ; SE_2043 .
GeneIDi 1055993.
KEGGi sep:SE2043.
PATRICi 19609952. VBIStaEpi113981_1996.

Phylogenomic databases

eggNOGi COG1210.
KOi K00963.
OrthoDBi EOG6Z9B3V.

Enzyme and pathway databases

UniPathwayi UPA00894 .
BioCyci SEPI176280:GCDG-2102-MONOMER.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF00483. NTP_transferase. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR01099. galU. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
    Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
    Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12228.

Entry informationi

Entry nameiGTAB_STAES
AccessioniPrimary (citable) accession number: Q8CR67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: June 11, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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