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Q8CR67

- GTAB_STAES

UniProt

Q8CR67 - GTAB_STAES

Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

gtaB

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 2 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of UDP-glucose from glucose-1-phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. a glycolipid found in the membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) By similarity.By similarity

    Catalytic activityi

    UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

    Pathwayi

    GO - Molecular functioni

    1. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. enterobacterial common antigen biosynthetic process Source: UniProtKB-UniPathway
    2. UDP-glucose metabolic process Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism

    Enzyme and pathway databases

    BioCyciSEPI176280:GCDG-2102-MONOMER.
    UniPathwayiUPA00894.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
    Alternative name(s):
    Alpha-D-glucosyl-1-phosphate uridylyltransferase
    UDP-glucose pyrophosphorylase
    Short name:
    UDPGP
    Uridine diphosphoglucose pyrophosphorylase
    Gene namesi
    Name:gtaB
    Ordered Locus Names:SE_2043
    OrganismiStaphylococcus epidermidis (strain ATCC 12228)
    Taxonomic identifieri176280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001411: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288UTP--glucose-1-phosphate uridylyltransferasePRO_0000308311Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi176280.SE2043.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CR67.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDPGP type 2 family.Curated

    Phylogenomic databases

    eggNOGiCOG1210.
    KOiK00963.
    OrthoDBiEOG6Z9B3V.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF00483. NTP_transferase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    TIGRFAMsiTIGR01099. galU. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8CR67-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEASKAGI    50
    EDIIIVTGKH KRAIEDHFDN QKELEMVLEN KGKADLLEKV QYSTDLANIF 100
    YVRQKEQKGL GHAIHTAKQF IGNEPFAVLL GDDIVESDTP AIKQLMDVYE 150
    ETGHSVIGVQ EVPESDTHRY GVIDPSAKEG SRYEVRQFVE KPKQGTAPSN 200
    LAIMGRYVLT PEIFDYLETQ QEGAGNEIQL TDAIERMNSK QQVYAYDFEG 250
    NRYDVGEKLG FVKTTIEYAL KDPEMSQDLK AFIKQLDI 288
    Length:288
    Mass (Da):32,424
    Last modified:October 23, 2007 - v2
    Checksum:iED5422E73E60672F
    GO

    Sequence cautioni

    The sequence AAO05684.1 differs from that shown. Reason: Frameshift at position 30.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015929 Genomic DNA. Translation: AAO05684.1. Frameshift.
    RefSeqiNP_765598.1. NC_004461.1.

    Genome annotation databases

    EnsemblBacteriaiAAO05684; AAO05684; SE_2043.
    GeneIDi1055993.
    KEGGisep:SE2043.
    PATRICi19609952. VBIStaEpi113981_1996.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015929 Genomic DNA. Translation: AAO05684.1 . Frameshift.
    RefSeqi NP_765598.1. NC_004461.1.

    3D structure databases

    ProteinModelPortali Q8CR67.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176280.SE2043.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO05684 ; AAO05684 ; SE_2043 .
    GeneIDi 1055993.
    KEGGi sep:SE2043.
    PATRICi 19609952. VBIStaEpi113981_1996.

    Phylogenomic databases

    eggNOGi COG1210.
    KOi K00963.
    OrthoDBi EOG6Z9B3V.

    Enzyme and pathway databases

    UniPathwayi UPA00894 .
    BioCyci SEPI176280:GCDG-2102-MONOMER.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR005771. GalU_uridylyltTrfase_bac/arc.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF00483. NTP_transferase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    TIGRFAMsi TIGR01099. galU. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
      Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
      Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 12228.

    Entry informationi

    Entry nameiGTAB_STAES
    AccessioniPrimary (citable) accession number: Q8CR67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3