Q8CR21 (PANC_STAES) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate synthetase
Short name=PS
EC=6.3.2.1

Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme

Gene names

Name:	panC
Ordered Locus Names:	SE_2140

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus epidermidis

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity. HAMAP-Rule MF_00158
Catalytic activity	ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP-Rule MF_00158
Pathway	Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP-Rule MF_00158
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00158.
Miscellaneous	The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity. HAMAP-Rule MF_00158
Sequence similarities	Belongs to the pantothenate synthetase family.

Ontologies

Keywords
Biological process	Pantothenate biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pantothenate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantoate-beta-alanine ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 286	286	Pantothenate synthetase HAMAP-Rule MF_00158		PRO_0000128275
Regions
	Nucleotide binding	31 – 38	8	ATP By similarity
	Nucleotide binding	148 – 151	4	ATP By similarity
	Nucleotide binding	185 – 188	4	ATP By similarity
Sites
	Active site	38	1	Proton donor By similarity
	Binding site	62	1	Beta-alanine By similarity
	Binding site	62	1	Pantoate By similarity
	Binding site	154	1	Pantoate By similarity
	Binding site	177	1	ATP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8CR21 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 8A60900223CE3B4F	FASTA	286	32,278
	10 20 30 40 50 60 MTKVITTINE MQSIVKQHQR EGKTIGFVPT MGALHDGHLT MMKQSVSEND LTVISIFVNP 70 80 90 100 110 120 LQFGPNEDFD AYPRQLDDDV AAVKKLQVDY VFHPSVDEMY PEELGIHLKV GHLAQVLEGA 130 140 150 160 170 180 QRPGHFEGVV TVVNKLFNIV QPDYAYFGKK DAQQLAIVEK MVKDFNLPVH VIGIDIVREK 190 200 210 220 230 240 DGLAKSSRNI YLTSEERKEA KHLYQSLRLA KNLYEAGERD SNEIIGQIAA YLNKNISGHI 250 260 270 280 DDLGIYSYPN LIQQSKIHGR IFISLAVKFS KARLIDNIII GDDYID

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015929 Genomic DNA. Translation: AAO05782.1.
RefSeq	NP_765695.1. NC_004461.1.
3D structure databases
ProteinModelPortal	Q8CR21.
ModBase	Search...
Protein-protein interaction databases
STRING	176280.SE2140.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO05782; AAO05782; SE_2140.
GeneID	1056192.
KEGG	sep:SE2140.
PATRIC	19610144. VBIStaEpi113981_2092.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0414.
KO	K01918.
OMA	EMDGLAM.
ProtClustDB	PRK00380.
Enzyme and pathway databases
UniPathway	UPA00028; UER00005.
Family and domain databases
Gene3D	3.40.50.620. 1 hit.
HAMAP	MF_00158. PanC.
InterPro	IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
PANTHER	PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfam	PF02569. Pantoate_ligase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00018. panC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PANC_STAES

Accession

Primary (citable) accession number: Q8CR21

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program