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Protein

Hypoxanthine-guanine phosphoribosyltransferase

Gene

hpt

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein.By similarity

Pathwayi: IMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from hypoxanthine.
Proteins known to be involved in this subpathway in this organism are:
  1. Hypoxanthine-guanine phosphoribosyltransferase (hpt)
This subpathway is part of the pathway IMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from hypoxanthine, the pathway IMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei102Proton acceptorBy similarity1
Binding sitei130IMPBy similarity1
Binding sitei152IMP; via carbonyl oxygenBy similarity1
Metal bindingi158MagnesiumBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi98 – 107IMPBy similarity10
Nucleotide bindingi157 – 158IMPBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage
LigandMagnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSEPI176280:G1G05-2342-MONOMER
UniPathwayiUPA00591; UER00648

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine-guanine phosphoribosyltransferase (EC:2.4.2.8)
Short name:
HGPRT
Short name:
HGPRTase
Gene namesi
Name:hpt
Ordered Locus Names:SE_2273
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001396181 – 179Hypoxanthine-guanine phosphoribosyltransferaseAdd BLAST179

Interactioni

Protein-protein interaction databases

STRINGi176280.SE2273

Structurei

3D structure databases

ProteinModelPortaliQ8CQV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108UGV Bacteria
COG0634 LUCA
KOiK00760
OMAiTMDWMAV

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
InterProiView protein in InterPro
IPR005904 Hxn_phspho_trans
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01203 HGPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CQV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKDLKNVLL SEEDIQNICK EMGAIITEDY KDRPLVCVGI LKGSVMFMAD
60 70 80 90 100
LIKRIDTHLS IDFMDVSSYH GGTESTGEVQ ILKDLGASIE NKDVLIIEDI
110 120 130 140 150
LETGTTLKSI TELLQSRKVN SLEIATLLDK PNRRKADIEA KYVGKKIPDE
160 170
FVVGYGLDYR ELYRNLPYIG TLKAEVYSK
Length:179
Mass (Da):20,185
Last modified:March 1, 2003 - v1
Checksum:iF80B151862CEF3CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA Translation: AAO05915.1
RefSeqiNP_765828.1, NC_004461.1
WP_001832216.1, NC_004461.1

Genome annotation databases

EnsemblBacteriaiAAO05915; AAO05915; SE_2273
GeneIDi1055869
KEGGisep:SE2273
PATRICifig|176280.10.peg.2216

Entry informationi

Entry nameiHPRT_STAES
AccessioniPrimary (citable) accession number: Q8CQV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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