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Q8CQN7 (THLA_STAES) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable acetyl-CoA acyltransferase
EC=2.3.1.9
Alternative name(s):
Acetoacetyl-CoA thiolase
Gene names
Ordered Locus Names:SE_2384
OrganismStaphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]
Taxonomic identifier176280 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 acetyl-CoA = CoA + acetoacetyl-CoA.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the thiolase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionacetyl-CoA C-acetyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 394394Probable acetyl-CoA acyltransferase
PRO_0000270510

Sites

Active site881Acyl-thioester intermediate By similarity
Active site3491Proton acceptor By similarity
Active site3781Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CQN7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: C95DCBE16F213195

FASTA39441,595
        10         20         30         40         50         60 
MSRIVLAEAY RTPIGVFGGV FKDIPAYELG ATVIRQILEH SQIDPNEINE VILGNVLQAG 

        70         80         90        100        110        120 
QGQNPARIAA IHGGVPEAVP SFTVNKVCGS GLKAIQLAYQ SIVAGDNEIV IAGGMESMSQ 

       130        140        150        160        170        180 
SPMLLKNSRF GFKMGNQTLE DSMIADGLTD KFNDYHMGIT AENLVEQYQI SRKEQDQFAF 

       190        200        210        220        230        240 
DSQQKASRAQ QAGVFDAEIV PVEVPQRKGD PLIISQDEGI RPQTTIDKLA QLRPAFKKDG 

       250        260        270        280        290        300 
SVTAGNASGI NDGAAAMLVM TEDKAKALGL QPIAVLDSFG ASGVAPSIMG IGPVEAIHKA 

       310        320        330        340        350        360 
LKRSNKVIND VDIFELNEAF AAQSIAVNRE LQLPQDKVNV NGGAIALGHP IGASGARTLV 

       370        380        390 
SLLHQLSDAK PTGVASLCIG GGQGIATVVS KYEV

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References

[1]"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12228.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015929 Genomic DNA. Translation: AAO06027.1.
RefSeqNP_765939.1. NC_004461.1.

3D structure databases

HSSPHSSP built from PDB template 1M3K based on UniProtKB P07097.
ProteinModelPortalQ8CQN7.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8CQN7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000039691; EBSTAP00000038324; EBSTAG00000039689.
GeneID1057154.
GenomeReviewsGene locus SE_2384 in contig AE015929_GR.
KEGGsep:SE2384.
PATRIC19610640. VBIStaEpi113981_2323.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0183.
GeneTreeEBGT00050000024085.
HOGENOMHBG370930.
OMANPSEINE.
PhylomeDBQ8CQN7.
ProtClustDBCLSK884583.

Enzyme and pathway databases

BioCycSEPI176280:SE_2384-MONOMER.

Family and domain databases

InterProIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 4 hits.
KOK00626.
PANTHERPTHR18919. Thiolase. 1 hit.
PfamPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMSSF53901. Thiolase-like. 2 hits.
TIGRFAMsTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTHLA_STAES
AccessionPrimary (citable) accession number: Q8CQN7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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