Q8CQF7 (COPB_STAES) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable copper-transporting P-type ATPase B
EC=3.6.3.-

Gene names

Name:	copB
Ordered Locus Names:	SE_0126

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus epidermidis

Protein attributes

Sequence length	674 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in copper transport By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]

Ontologies

Keywords
Biological process	Copper transport Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Copper Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	copper ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cation-transporting ATPase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 674	674	Probable copper-transporting P-type ATPase B		PRO_0000350606
Regions
	Transmembrane	32 – 52	21	Helical; Potential
	Transmembrane	57 – 77	21	Helical; Potential
	Transmembrane	95 – 115	21	Helical; Potential
	Transmembrane	127 – 147	21	Helical; Potential
	Transmembrane	284 – 304	21	Helical; Potential
	Transmembrane	315 – 335	21	Helical; Potential
	Transmembrane	623 – 645	23	Helical; Potential
	Transmembrane	649 – 671	23	Helical; Potential
	Compositional bias	3 – 25	23	His-rich
Sites
	Active site	367	1	4-aspartylphosphate intermediate By similarity
	Metal binding	565	1	Magnesium By similarity
	Metal binding	569	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8CQF7 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 36B60C8EB08FE6ED	FASTA	674	73,165
	10 20 30 40 50 60 MNHSNQMHHD NHESHNHHSG HAHHHGNFKV KFFVSLIFAI PIILLSPLMG INLPFQFTFP 70 80 90 100 110 120 GSEWVVLILS TILFFYGGKP FLSGGKDEIA TKKPGMMTLV ALGISVAYIY SLYAFYMNNF 130 140 150 160 170 180 SSATGHTMDF FWELATLILI MLLGHWIEMN AVGNAGDALK KMAELLPNSA IKVMDNGQRE 190 200 210 220 230 240 EVKISDIMTD DIVEVKAGES IPTDGIIVQG QTSIDESLVT GESKKVQKNQ NDNVIGGSIN 250 260 270 280 290 300 GSGTIQVKVT AVGEDGYLSQ VMGLVNQAQN DKSSAELLSD KVAGYLFYFA VIVGVISFIV 310 320 330 340 350 360 WMLIQNDVDF ALERLVTVLV IACPHALGLA IPLVTARSTS IGAHNGLIIK NRESVEIAQH 370 380 390 400 410 420 IDYVMMDKTG TLTEGNFSVN HYESFKNDLS NDTILSLFAS LESQSNHPLA ISIVDFAKSK 430 440 450 460 470 480 NVSFTNPQDV NNIPGVGLEG LIDNKTYKIT NVSYLDKHKL NYDDDLFTKL AQQGNSISYL 490 500 510 520 530 540 IEDQQVIGMI AQGDQIKESS KQMVADLLSR NITPVMLTGD NNEVAHAVAK ELGISDVHAQ 550 560 570 580 590 600 LMPEDKESII KDYQSNGNKV MMVGDGINDA PSLIRADIGI AIGAGTDVAV DSGDIILVKS 610 620 630 640 650 660 NPSDIVHFLT LSNNTMRKMV QNLWWGAGYN IVAVPLAAGA LAFVGLILSP AVGAILMSLS 670 TVIVAINAFT LKLK

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015929 Genomic DNA. Translation: AAO03723.1.
RefSeq	NP_763681.1. NC_004461.1.
3D structure databases
ProteinModelPortal	Q8CQF7.
ModBase	Search...
Protein-protein interaction databases
STRING	176280.SE0126.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO03723; AAO03723; SE_0126.
GeneID	1056566.
KEGG	sep:SE0126.
PATRIC	19606077. VBIStaEpi113981_0117.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2217.
OMA	ELSHASY.
ProtClustDB	CLSK911889.
Enzyme and pathway databases
BioCyc	SEPI176280:GCDG-128-MONOMER.
Family and domain databases
Gene3D	2.70.150.10. 1 hit. 3.40.1110.10. 1 hit. 3.40.50.1000. 2 hits.
InterPro	IPR023299. ATPase_P-typ_cyto_domN. IPR018303. ATPase_P-typ_P_site. IPR008250. ATPase_P-typ_transduc_dom_A. IPR027256. Cation_transp_P-typ_ATPase_IB. IPR001757. Cation_transp_P_typ_ATPase. IPR023214. HAD-like_dom. [Graphical view]
PANTHER	PTHR24093. PTHR24093. 1 hit.
Pfam	PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00120. HATPASE.
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01525. ATPase-IB_hvy. 1 hit. TIGR01494. ATPase_P-type. 1 hit.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COPB_STAES

Accession

Primary (citable) accession number: Q8CQF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 23, 2008
Last sequence update:	March 1, 2003
Last modified:	May 29, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program