Q8CQE8 (MQO3_STAES) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable malate:quinone oxidoreductase 3
EC=1.1.5.4

Alternative name(s):
MQO 3
Malate dehydrogenase [quinone] 3

Gene names

Name:	mqo3
Ordered Locus Names:	SE_0157

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	494 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212
Cofactor	FAD By similarity. HAMAP MF_00212
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212
Sequence similarities	Belongs to the MQO family.
Sequence caution	The sequence AAO03754.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	malate dehydrogenase (menaquinone) activity Inferred from electronic annotation. Source: EC malate dehydrogenase (quinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 494	494	Probable malate:quinone oxidoreductase 3 HAMAP MF_00212		PRO_0000128751

Sequences

	Sequence		Length	Mass (Da)
	Q8CQE8 [UniParc]. Last modified July 19, 2005. Version 2. Checksum: 1FAA2DE8633BC1DF	FASTA	494	55,608
	10 20 30 40 50 60 MSEANHKNIV VVGAGIIGTS VATMLSKVSP NWHIDMFERL EGAGIESSNE NNNAGTGHAA 70 80 90 100 110 120 LCELNYTVEQ DDGSIDASKA QEINEQFELS RQFWGNLVKN GDISNPEEFI QPLPHISFVM 130 140 150 160 170 180 GPTNVNFLRK RYETLKTLPM FDTIEYTEDM ETMRKWMPLM MENREPGHQM AASKIDEGTD 190 200 210 220 230 240 VNYGALTRKL AHYLEQKSNV SLKYNHDVVD LTQREDGKWE VVVENRETKE KVTKIADKVF 250 260 270 280 290 300 IGAGGHSIPL LQKSGVKQRE HLGGFPISGQ FLRCTNPDII KQHAAKVYSK EPQGKPPMTV 310 320 330 340 350 360 PHLDTRYING KQTLLFGPYA NIGPKFLKFG SNLDLFESIK PYNITTMLAS AVKNVPLIKY 370 380 390 400 410 420 SIDQMIKTKE GCMNYLRTFI PDAKDEDWEL YTAGKRVQVI KDSEQHGKGF VVFGTEVVNS 430 440 450 460 470 480 DDNSMIALLG ESPGASTSLS VVLEVLEKNF ADDKEAWEPV VKEMVPTYGR SLINDEKLMR 490 ETRRETSKNL HLNR

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015929 Genomic DNA. Translation: AAO03754.1. Different initiation.
RefSeq	NP_763712.1. NC_004461.1.
3D structure databases
ProteinModelPortal	Q8CQE8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CQE8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000040227; EBSTAP00000038860; EBSTAG00000040225.
GeneID	1056443.
GenomeReviews	Gene locus SE_0157 in contig AE015929_GR.
KEGG	sep:SE0157.
PATRIC	19606133. VBIStaEpi113981_0145.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0579.
GeneTree	EBGT00050000024300.
HOGENOM	HBG289663.
OMA	VAGSFYM.
PhylomeDB	Q8CQE8.
ProtClustDB	PRK13339.
Enzyme and pathway databases
BioCyc	SEPI176280:SE_0157-MONOMER.
Family and domain databases
HAMAP	MF_00212. MQO. [Tree]
InterPro	IPR006231. Malate_quinone_OxRdtase. [Graphical view]
KO	K00116.
PANTHER	PTHR13847:SF14. PTHR13847:SF14. 1 hit.
Pfam	PF06039. Mqo. 1 hit. [Graphical view]
TIGRFAMs	TIGR01320. Mal_quin_oxido. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MQO3_STAES

Accession

Primary (citable) accession number: Q8CQE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	July 19, 2005
Last modified:	January 25, 2012
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program