ID   BUTA_STAES              Reviewed;         257 AA.
AC   Q8CQD2;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   16-JUN-2009, entry version 40.
DE   RecName: Full=Acetoin(diacetyl) reductase;
DE            Short=AR;
DE            EC=1.1.1.5;
DE   AltName: Full=Acetoin dehydrogenase;
DE   AltName: Full=Meso-2,3-butanediol dehydrogenase;
GN   Name=butA; OrderedLocusNames=SE_0197;
OS   Staphylococcus epidermidis (strain ATCC 12228).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22832016; PubMed=12950922;
RX   DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J.,
RA   Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z.,
RA   Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Catalyzes the reversible reduction of acetoin to 2,3-
CC       butanediol in the presence of NADH (By similarity).
CC   -!- CATALYTIC ACTIVITY: Acetoin + NAD(+) = diacetyl + NADH.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family.
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DR   EMBL; AE015929; AAO03794.1; -; Genomic_DNA.
DR   RefSeq; NP_763752.1; -.
DR   HSSP; Q48436; 1GEG.
DR   GeneID; 1056361; -.
DR   GenomeReviews; AE015929_GR; SE_0197.
DR   KEGG; sep:SE0197; -.
DR   HOGENOM; Q8CQD2; -.
DR   OMA; Q8CQD2; IAGHESY.
DR   BioCyc; SEPI176280:SE_0197-MON; -.
DR   GO; GO:0019152; F:acetoin dehydrogenase activity; IEA:EC.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0045150; P:acetoin catabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR014007; 23BDH.
DR   InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR   InterPro; IPR002347; Glc/ribitol_DH.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR19410; ADH_short_C2; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   TIGRFAMs; TIGR02415; 23BDH; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    257       Acetoin(diacetyl) reductase.
FT                                /FTId=PRO_0000054545.
FT   NP_BIND       6     30       NAD (By similarity).
FT   ACT_SITE    152    152       Proton acceptor (By similarity).
FT   ACT_SITE    156    156       By similarity.
FT   BINDING     139    139       Substrate (By similarity).
SQ   SEQUENCE   257 AA;  27917 MW;  A5E573EC97BEA692 CRC64;
     MSKTAIITGA AGGLGKGIAE RLANDGFNIV LQDINEALLL ETEKEFKEKG YQAVAYKSDV
     SKKKEQEELV QFAVTEFGQL DVMVNNAGVD AVTPILEIGE EELSKLFNIN VFGTLFGIQA
     AANQFIKQKS KGKIINACSI AGHESYEVLG TYSATKHSVR SFTQTAAKEL ADKGITVNAY
     CPGVAKTEMW DRIDEEMVKL DDSLEIGDAF EAFSSEIKLG RYQEPSDVAN LVSFLASNDS
     DYITGQSILT DGGLVYR
//