Reviewed, UniProtKB/Swiss-Prot Q8CQD2 (BUTA_STAES)

Names and origin

Protein names

Recommended name:
    Acetoin(diacetyl) reductase
      Short name=AR
    EC=1.1.1.5
Alternative name(s):
    Acetoin dehydrogenase
    Meso-2,3-butanediol dehydrogenase

Gene names

Name:	butA
Ordered Locus Names:	SE_0197

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reversible reduction of acetoin to 2,3-butanediol in the presence of NADH By similarity.
Catalytic activity	Acetoin + NAD(+) = diacetyl + NADH.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	acetoin catabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	acetoin dehydrogenase activity Inferred from electronic annotation. Source: InterPro binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Acetoin(diacetyl) reductase		PRO_0000054545
Regions
	Nucleotide binding	6 – 30	25	NAD By similarity
Sites
	Active site	152	1	Proton acceptor By similarity
	Active site	156	1	By similarity
	Binding site	139	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8CQD2-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: A5E573EC97BEA692	FASTA	257	27,917
	10 20 30 40 50 60 MSKTAIITGA AGGLGKGIAE RLANDGFNIV LQDINEALLL ETEKEFKEKG YQAVAYKSDV 70 80 90 100 110 120 SKKKEQEELV QFAVTEFGQL DVMVNNAGVD AVTPILEIGE EELSKLFNIN VFGTLFGIQA 130 140 150 160 170 180 AANQFIKQKS KGKIINACSI AGHESYEVLG TYSATKHSVR SFTQTAAKEL ADKGITVNAY 190 200 210 220 230 240 CPGVAKTEMW DRIDEEMVKL DDSLEIGDAF EAFSSEIKLG RYQEPSDVAN LVSFLASNDS 250 DYITGQSILT DGGLVYR

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015929 Genomic DNA. Translation: AAO03794.1.
RefSeq	NP_763752.1.
3D structure databases
HSSP	HSSP built from PDB template 1GEG based on UniProtKB Q48436.
ModBase	Search...
Genome annotation databases
GeneID	1056361.
GenomeReviews	Gene locus SE_0197 in contig AE015929_GR.
KEGG	sep:SE0197.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8CQD2.
Enzyme and pathway databases
BioCyc	SEPI176280:SE_0197-MON.
Family and domain databases
InterPro	IPR014007. 23BDH. IPR002198. DHase_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DHase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
TIGRFAMs	TIGR02415. 23BDH. 1 hit.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BUTA_STAES

Accession

Primary (citable) accession number: Q8CQD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
Last sequence update:	March 1, 2003
Last modified:	November 25, 2008
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)