Q8CQ96 (MQO2_STAES) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable malate:quinone oxidoreductase 2
EC=1.1.5.4

Alternative name(s):
MQO 2
Malate dehydrogenase [quinone] 2

Gene names

Name:	mqo2
Ordered Locus Names:	SE_0266

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212
Cofactor	FAD By similarity. HAMAP MF_00212
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212
Sequence similarities	Belongs to the MQO family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	malate dehydrogenase (menaquinone) activity Inferred from electronic annotation. Source: EC malate dehydrogenase (quinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 498	498	Probable malate:quinone oxidoreductase 2 HAMAP MF_00212		PRO_0000128750

Sequences

	Sequence		Length	Mass (Da)
	Q8CQ96 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 63817210B62BDAD3	FASTA	498	56,222
	10 20 30 40 50 60 MANKESKNVV IIGAGVLSTT FGSMIKELEP DWNIKLYERL DRPGIESSNE RNNAGTGHAA 70 80 90 100 110 120 LCELNYTVQQ PDGSIDIEKA KEINEQFEIS KQFWGHLVKS GNISNPRDFI NPLPHISFVR 130 140 150 160 170 180 GKNNVKFLKN RYEAMRNFPM FDNIEYTEDI EEMRKWMPLM MTGRTGNEIM AASKIDEGTD 190 200 210 220 230 240 VNYGELTRKM AKSIEKHPNA DVQYNHEVIN FNRRKDGTWE VKVKNRNSGD VETVLADYVF 250 260 270 280 290 300 IGAGGGAIPL LQKTGIPESK HLGGFPISGQ FLICTNPDVI NEHDVKVYGK EPPGTPPMTV 310 320 330 340 350 360 PHLDTRYIEG ERTLLFGPFA NIGPKFLRNG SNLDLFKSVK PYNITTLLAS AVKNLPLIKY 370 380 390 400 410 420 SIDQVLMTKE GCMNHLRTFY PEARDEDWQL YTAGKRVQVI KDTKEHGKGF IQFGTEVVNS 430 440 450 460 470 480 KDHSVIALLG ESPGASTSVS VALEVLEKNF AEYEKDWTPK LQKMIPSYGK SLIDDVKLMR 490 ATRKQTSKDL ELNYYESK

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015929 Genomic DNA. Translation: AAO03863.1.
RefSeq	NP_763821.1. NC_004461.1.
3D structure databases
ProteinModelPortal	Q8CQ96.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CQ96.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000040854; EBSTAP00000039487; EBSTAG00000040852.
GeneID	1058087.
GenomeReviews	Gene locus SE_0266 in contig AE015929_GR.
KEGG	sep:SE0266.
PATRIC	19606329. VBIStaEpi113981_0243.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0579.
GeneTree	EBGT00050000024300.
HOGENOM	HBG289663.
OMA	FLICTNP.
PhylomeDB	Q8CQ96.
ProtClustDB	PRK13339.
Enzyme and pathway databases
BioCyc	SEPI176280:SE_0266-MONOMER.
Family and domain databases
HAMAP	MF_00212. MQO. [Tree]
InterPro	IPR006231. Malate_quinone_OxRdtase. [Graphical view]
KO	K00116.
PANTHER	PTHR13847:SF14. PTHR13847:SF14. 1 hit.
Pfam	PF06039. Mqo. 1 hit. [Graphical view]
TIGRFAMs	TIGR01320. Mal_quin_oxido. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MQO2_STAES

Accession

Primary (citable) accession number: Q8CQ96

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program