Reviewed, UniProtKB/Swiss-Prot Q8CQ96 (MQO2_STAES)

Names and origin

Protein names

Recommended name:
    Probable malate:quinone oxidoreductase 2
    EC=1.1.99.16
Alternative name(s):
    Malate dehydrogenase [acceptor] 2
    MQO 2

Gene names

Name:	mqo2
Ordered Locus Names:	SE_0266

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-malate + acceptor = oxaloacetate + reduced acceptor. HAMAP MF_00212
Cofactor	FAD By similarity. HAMAP MF_00212
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212
Sequence similarities	Belongs to the MQO family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Molecular function	malate dehydrogenase (acceptor) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 498	498	Probable malate:quinone oxidoreductase 2 HAMAP MF_00212		PRO_0000128750

Sequences

	Sequence		Length	Mass (Da)
	Q8CQ96-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 63817210B62BDAD3	FASTA	498	56,222
	10 20 30 40 50 60 MANKESKNVV IIGAGVLSTT FGSMIKELEP DWNIKLYERL DRPGIESSNE RNNAGTGHAA 70 80 90 100 110 120 LCELNYTVQQ PDGSIDIEKA KEINEQFEIS KQFWGHLVKS GNISNPRDFI NPLPHISFVR 130 140 150 160 170 180 GKNNVKFLKN RYEAMRNFPM FDNIEYTEDI EEMRKWMPLM MTGRTGNEIM AASKIDEGTD 190 200 210 220 230 240 VNYGELTRKM AKSIEKHPNA DVQYNHEVIN FNRRKDGTWE VKVKNRNSGD VETVLADYVF 250 260 270 280 290 300 IGAGGGAIPL LQKTGIPESK HLGGFPISGQ FLICTNPDVI NEHDVKVYGK EPPGTPPMTV 310 320 330 340 350 360 PHLDTRYIEG ERTLLFGPFA NIGPKFLRNG SNLDLFKSVK PYNITTLLAS AVKNLPLIKY 370 380 390 400 410 420 SIDQVLMTKE GCMNHLRTFY PEARDEDWQL YTAGKRVQVI KDTKEHGKGF IQFGTEVVNS 430 440 450 460 470 480 KDHSVIALLG ESPGASTSVS VALEVLEKNF AEYEKDWTPK LQKMIPSYGK SLIDDVKLMR 490 ATRKQTSKDL ELNYYESK

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015929 Genomic DNA. Translation: AAO03863.1.
RefSeq	NP_763821.1.
3D structure databases
SMR	Q8CQ96. Positions 5-277.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CQ96.
Genome annotation databases
GeneID	1058087.
GenomeReviews	Gene locus SE_0266 in contig AE015929_GR.
KEGG	sep:SE0266.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0579.
HOGENOM	HBG289663.
OMA	FLICTNP.
PhylomeDB	Q8CQ96.
Enzyme and pathway databases
BioCyc	SEPI176280:SE_0266-MONOMER.
Family and domain databases
HAMAP	MF_00212. MQO. [Tree]
InterPro	IPR006231. Malate_quinone_OxRdtase. [Graphical view]
Pfam	PF06039. Mqo. 1 hit. [Graphical view]
TIGRFAMs	TIGR01320. mal_quin_oxido. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MQO2_STAES

Accession

Primary (citable) accession number: Q8CQ96

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2003
Last sequence update:	March 1, 2003
Last modified:	February 9, 2010
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)