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Q8CQ95

- HISX_STAES

UniProt

Q8CQ95 - HISX_STAES

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Protein
Histidinol dehydrogenase
Gene
hisD, SE_0272
Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161NAD By similarity
Binding sitei177 – 1771NAD By similarity
Binding sitei200 – 2001NAD By similarity
Binding sitei223 – 2231Substrate By similarity
Metal bindingi245 – 2451Zinc By similarity
Binding sitei245 – 2451Substrate By similarity
Metal bindingi248 – 2481Zinc By similarity
Binding sitei248 – 2481Substrate By similarity
Active sitei313 – 3131Proton acceptor By similarity
Active sitei314 – 3141Proton acceptor By similarity
Binding sitei314 – 3141Substrate By similarity
Metal bindingi347 – 3471Zinc By similarity
Binding sitei347 – 3471Substrate By similarity
Binding sitei401 – 4011Substrate By similarity
Metal bindingi406 – 4061Zinc By similarity
Binding sitei406 – 4061Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciSEPI176280:GCDG-274-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:SE_0272
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001411: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Histidinol dehydrogenaseUniRule annotation
PRO_0000135855Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176280.SE0272.

Structurei

3D structure databases

ProteinModelPortaliQ8CQ95.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiGFLFHAN.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CQ95-1 [UniParc]FASTAAdd to Basket

« Hide

MLSAQQFLKE FNNVESLNES LYEIVSHICE EVKLQGDKAL KNYNLQFDQV    50
ETEKLELEQS QLKNAYDMLD NETRDALEQS YQRIKVYQEN IKVKQESSQQ 100
TECYERYHPI ERVGIYVPGG KASYPSTVLM TATLAQVAGV NEITVVTPPQ 150
NNGICQEVLA ACYITGVHHV YQVGGAQSIA ALTYGTETIK KVDKIVGPGN 200
QYVAYAKKFV FGQVGIDQIA GPTEIALIID ESADLDAIAY DVFAQAEHDE 250
MACTYVISEN EKVLNQLNTI IQEKLQYVER QDIISQSIAN HHYLILAQDT 300
EEACLIMNTI APEHASIQTR APEMYIDKVK YVGALFLGHF SPEVIGDYMA 350
GPSHVLPTNQ TARFTNGLSV NDFMTRHSVI HLSQKTFNEV AESAEHIAHI 400
ESLFNHEKSI HVRR 414
Length:414
Mass (Da):46,494
Last modified:March 1, 2003 - v1
Checksum:i5D96007ECE4E1843
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO03869.1.
RefSeqiNP_763827.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO03869; AAO03869; SE_0272.
GeneIDi1058081.
KEGGisep:SE0272.
PATRICi19606343. VBIStaEpi113981_0250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO03869.1 .
RefSeqi NP_763827.1. NC_004461.1.

3D structure databases

ProteinModelPortali Q8CQ95.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176280.SE0272.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO03869 ; AAO03869 ; SE_0272 .
GeneIDi 1058081.
KEGGi sep:SE0272.
PATRICi 19606343. VBIStaEpi113981_0250.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi GFLFHAN.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci SEPI176280:GCDG-274-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
    Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
    Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12228.

Entry informationi

Entry nameiHISX_STAES
AccessioniPrimary (citable) accession number: Q8CQ95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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