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Q8CQ95

- HISX_STAES

UniProt

Q8CQ95 - HISX_STAES

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei116 – 1161NADUniRule annotation
    Binding sitei177 – 1771NADUniRule annotation
    Binding sitei200 – 2001NADUniRule annotation
    Binding sitei223 – 2231SubstrateUniRule annotation
    Metal bindingi245 – 2451ZincUniRule annotation
    Binding sitei245 – 2451SubstrateUniRule annotation
    Metal bindingi248 – 2481ZincUniRule annotation
    Binding sitei248 – 2481SubstrateUniRule annotation
    Active sitei313 – 3131Proton acceptorUniRule annotation
    Active sitei314 – 3141Proton acceptorUniRule annotation
    Binding sitei314 – 3141SubstrateUniRule annotation
    Metal bindingi347 – 3471ZincUniRule annotation
    Binding sitei347 – 3471SubstrateUniRule annotation
    Binding sitei401 – 4011SubstrateUniRule annotation
    Metal bindingi406 – 4061ZincUniRule annotation
    Binding sitei406 – 4061SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciSEPI176280:GCDG-274-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:SE_0272
    OrganismiStaphylococcus epidermidis (strain ATCC 12228)
    Taxonomic identifieri176280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001411: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 414414Histidinol dehydrogenasePRO_0000135855Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi176280.SE0272.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CQ95.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    KOiK00013.
    OMAiGFLFHAN.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CQ95-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSAQQFLKE FNNVESLNES LYEIVSHICE EVKLQGDKAL KNYNLQFDQV    50
    ETEKLELEQS QLKNAYDMLD NETRDALEQS YQRIKVYQEN IKVKQESSQQ 100
    TECYERYHPI ERVGIYVPGG KASYPSTVLM TATLAQVAGV NEITVVTPPQ 150
    NNGICQEVLA ACYITGVHHV YQVGGAQSIA ALTYGTETIK KVDKIVGPGN 200
    QYVAYAKKFV FGQVGIDQIA GPTEIALIID ESADLDAIAY DVFAQAEHDE 250
    MACTYVISEN EKVLNQLNTI IQEKLQYVER QDIISQSIAN HHYLILAQDT 300
    EEACLIMNTI APEHASIQTR APEMYIDKVK YVGALFLGHF SPEVIGDYMA 350
    GPSHVLPTNQ TARFTNGLSV NDFMTRHSVI HLSQKTFNEV AESAEHIAHI 400
    ESLFNHEKSI HVRR 414
    Length:414
    Mass (Da):46,494
    Last modified:March 1, 2003 - v1
    Checksum:i5D96007ECE4E1843
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015929 Genomic DNA. Translation: AAO03869.1.
    RefSeqiNP_763827.1. NC_004461.1.

    Genome annotation databases

    EnsemblBacteriaiAAO03869; AAO03869; SE_0272.
    GeneIDi1058081.
    KEGGisep:SE0272.
    PATRICi19606343. VBIStaEpi113981_0250.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015929 Genomic DNA. Translation: AAO03869.1 .
    RefSeqi NP_763827.1. NC_004461.1.

    3D structure databases

    ProteinModelPortali Q8CQ95.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176280.SE0272.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO03869 ; AAO03869 ; SE_0272 .
    GeneIDi 1058081.
    KEGGi sep:SE0272.
    PATRICi 19606343. VBIStaEpi113981_0250.

    Phylogenomic databases

    eggNOGi COG0141.
    KOi K00013.
    OMAi GFLFHAN.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci SEPI176280:GCDG-274-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
      Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
      Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 12228.

    Entry informationi

    Entry nameiHISX_STAES
    AccessioniPrimary (citable) accession number: Q8CQ95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3