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Q8CQ94 (HIS7_STAES) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Imidazoleglycerol-phosphate dehydratase

Short name=IGPD
EC=4.2.1.19
Gene names
Name:hisB
Ordered Locus Names:SE_0273
OrganismStaphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]
Taxonomic identifier176280 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length192 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. HAMAP-Rule MF_00076

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. HAMAP-Rule MF_00076

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00076.

Sequence similarities

Belongs to the imidazoleglycerol-phosphate dehydratase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionimidazoleglycerol-phosphate dehydratase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 192192Imidazoleglycerol-phosphate dehydratase HAMAP-Rule MF_00076
PRO_0000158171

Sequences

Sequence LengthMass (Da)Tools
Q8CQ94 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 6145C4C5C488A18A

FASTA19221,448
        10         20         30         40         50         60 
MNYQIKRNTE ETQLNISLAN NGTQSHINTG VGFLDHMLTL FTFHSGLTLS IEATGDTYVD 

        70         80         90        100        110        120 
DHHITEDIGI VIGQLLLELV KTQQSFTRYG CSYVPMDETL ARTVVDISGR PYFSFNSKLS 

       130        140        150        160        170        180 
AQKVGTFDTE LVEEFFRALV INARLTVHID LLRGGNTHHE IEAIFKSFAR ALKISLAQNE 

       190 
DGRIPSSKGV IE 

« Hide

References

[1]"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12228.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015929 Genomic DNA. Translation: AAO03870.1.
RefSeqNP_763828.1. NC_004461.1.

3D structure databases

ProteinModelPortalQ8CQ94.
SMRQ8CQ94. Positions 1-176.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176280.SE0273.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO03870; AAO03870; SE_0273.
GeneID1058078.
KEGGsep:SE0273.
PATRIC19606345. VBIStaEpi113981_0251.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0131.
KOK01693.
OMALTHMVET.
OrthoDBEOG60PHGP.

Enzyme and pathway databases

BioCycSEPI176280:GCDG-275-MONOMER.
UniPathwayUPA00031; UER00011.

Family and domain databases

HAMAPMF_00076. HisB.
InterProIPR000807. ImidazoleglycerolP_deHydtase.
IPR020565. ImidazoleglycerP_deHydtase_CS.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERPTHR23133:SF2. PTHR23133:SF2. 1 hit.
PfamPF00475. IGPD. 1 hit.
[Graphical view]
SUPFAMSSF54211. SSF54211. 2 hits.
PROSITEPS00954. IGP_DEHYDRATASE_1. 1 hit.
PS00955. IGP_DEHYDRATASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHIS7_STAES
AccessionPrimary (citable) accession number: Q8CQ94
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways