Q8CQ94 (HIS7_STAES) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Imidazoleglycerol-phosphate dehydratase
Short name=IGPD
EC=4.2.1.19

Gene names

Name:	hisB
Ordered Locus Names:	SE_0273

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus epidermidis

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. HAMAP-Rule MF_00076
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. HAMAP-Rule MF_00076
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the imidazoleglycerol-phosphate dehydratase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	imidazoleglycerol-phosphate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 192	192	Imidazoleglycerol-phosphate dehydratase HAMAP-Rule MF_00076		PRO_0000158171

Sequences

	Sequence		Length	Mass (Da)
	Q8CQ94 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 6145C4C5C488A18A	FASTA	192	21,448
	10 20 30 40 50 60 MNYQIKRNTE ETQLNISLAN NGTQSHINTG VGFLDHMLTL FTFHSGLTLS IEATGDTYVD 70 80 90 100 110 120 DHHITEDIGI VIGQLLLELV KTQQSFTRYG CSYVPMDETL ARTVVDISGR PYFSFNSKLS 130 140 150 160 170 180 AQKVGTFDTE LVEEFFRALV INARLTVHID LLRGGNTHHE IEAIFKSFAR ALKISLAQNE 190 DGRIPSSKGV IE

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015929 Genomic DNA. Translation: AAO03870.1.
RefSeq	NP_763828.1. NC_004461.1.
3D structure databases
ProteinModelPortal	Q8CQ94.
SMR	Q8CQ94. Positions 1-176.
ModBase	Search...
Protein-protein interaction databases
STRING	176280.SE0273.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO03870; AAO03870; SE_0273.
GeneID	1058078.
KEGG	sep:SE0273.
PATRIC	19606345. VBIStaEpi113981_0251.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0131.
KO	K01693.
OMA	HHIVEAC.
ProtClustDB	PRK00951.
Enzyme and pathway databases
UniPathway	UPA00031; UER00011.
Family and domain databases
HAMAP	MF_00076. HisB.
InterPro	IPR000807. ImidazoleglycerolP_deHydtase. IPR020565. ImidazoleglycerP_deHydtase_CS. IPR020568. Ribosomal_S5_D2-typ_fold. [Graphical view]
PANTHER	PTHR23133:SF2. PTHR23133:SF2. 1 hit.
Pfam	PF00475. IGPD. 1 hit. [Graphical view]
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
PROSITE	PS00954. IGP_DEHYDRATASE_1. 1 hit. PS00955. IGP_DEHYDRATASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS7_STAES

Accession

Primary (citable) accession number: Q8CQ94

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program