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Q8CQ94

- HIS7_STAES

UniProt

Q8CQ94 - HIS7_STAES

Protein

Imidazoleglycerol-phosphate dehydratase

Gene

hisB

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. imidazoleglycerol-phosphate dehydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Enzyme and pathway databases

    BioCyciSEPI176280:GCDG-275-MONOMER.
    UniPathwayiUPA00031; UER00011.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Imidazoleglycerol-phosphate dehydrataseUniRule annotation (EC:4.2.1.19UniRule annotation)
    Short name:
    IGPDUniRule annotation
    Gene namesi
    Name:hisBUniRule annotation
    Ordered Locus Names:SE_0273
    OrganismiStaphylococcus epidermidis (strain ATCC 12228)
    Taxonomic identifieri176280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001411: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 192192Imidazoleglycerol-phosphate dehydratasePRO_0000158171Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi176280.SE0273.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CQ94.
    SMRiQ8CQ94. Positions 1-176.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the imidazoleglycerol-phosphate dehydratase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0131.
    KOiK01693.
    OMAiLTHMVET.
    OrthoDBiEOG60PHGP.

    Family and domain databases

    HAMAPiMF_00076. HisB.
    InterProiIPR000807. ImidazoleglycerolP_deHydtase.
    IPR020565. ImidazoleglycerP_deHydtase_CS.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view]
    PANTHERiPTHR23133:SF2. PTHR23133:SF2. 1 hit.
    PfamiPF00475. IGPD. 1 hit.
    [Graphical view]
    SUPFAMiSSF54211. SSF54211. 2 hits.
    PROSITEiPS00954. IGP_DEHYDRATASE_1. 1 hit.
    PS00955. IGP_DEHYDRATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CQ94-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNYQIKRNTE ETQLNISLAN NGTQSHINTG VGFLDHMLTL FTFHSGLTLS    50
    IEATGDTYVD DHHITEDIGI VIGQLLLELV KTQQSFTRYG CSYVPMDETL 100
    ARTVVDISGR PYFSFNSKLS AQKVGTFDTE LVEEFFRALV INARLTVHID 150
    LLRGGNTHHE IEAIFKSFAR ALKISLAQNE DGRIPSSKGV IE 192
    Length:192
    Mass (Da):21,448
    Last modified:March 1, 2003 - v1
    Checksum:i6145C4C5C488A18A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015929 Genomic DNA. Translation: AAO03870.1.
    RefSeqiNP_763828.1. NC_004461.1.

    Genome annotation databases

    EnsemblBacteriaiAAO03870; AAO03870; SE_0273.
    GeneIDi1058078.
    KEGGisep:SE0273.
    PATRICi19606345. VBIStaEpi113981_0251.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015929 Genomic DNA. Translation: AAO03870.1 .
    RefSeqi NP_763828.1. NC_004461.1.

    3D structure databases

    ProteinModelPortali Q8CQ94.
    SMRi Q8CQ94. Positions 1-176.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176280.SE0273.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO03870 ; AAO03870 ; SE_0273 .
    GeneIDi 1058078.
    KEGGi sep:SE0273.
    PATRICi 19606345. VBIStaEpi113981_0251.

    Phylogenomic databases

    eggNOGi COG0131.
    KOi K01693.
    OMAi LTHMVET.
    OrthoDBi EOG60PHGP.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00011 .
    BioCyci SEPI176280:GCDG-275-MONOMER.

    Family and domain databases

    HAMAPi MF_00076. HisB.
    InterProi IPR000807. ImidazoleglycerolP_deHydtase.
    IPR020565. ImidazoleglycerP_deHydtase_CS.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view ]
    PANTHERi PTHR23133:SF2. PTHR23133:SF2. 1 hit.
    Pfami PF00475. IGPD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54211. SSF54211. 2 hits.
    PROSITEi PS00954. IGP_DEHYDRATASE_1. 1 hit.
    PS00955. IGP_DEHYDRATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
      Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
      Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 12228.

    Entry informationi

    Entry nameiHIS7_STAES
    AccessioniPrimary (citable) accession number: Q8CQ94
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3